Gérard Lapluye

Catalytic activity of a copper(II)-oxidized glutathione complex on aqueous superoxide ion dismutation

The study of the catalytic activity of a Cu(II)-oxidized glutathione system upon the disproportionation of superoxide radicals shows that the mononuclear complex MA catalyzes dismutation in the pH range 7-9. The corresponding first-order rate constant of value kcat congruent to 6 X 10(6) M-1 sec-1 is pH independent, whereas the second-order rate constant ks for the reference solutions is pH dependent. The kcat constant is about 10-, 100-, and 300-fold higher than the ks constant at pH 7, 8, and 9, respectively. The measured effect is explained in terms of free axial sites in the square-planar arrangement around the copper ion.

SOD mimicking properties of copper (II) complexes: health side effects.

Controlled regulation of the Superoxide ion in living systems is an important challenge, due to the multiple pathological involvements of this radicalion.

Potential study of basement membrane

The membrane potential of a basement membrane (bovine-anterior-lens-capsule) was studied by use of the Gibbs-Donnan systems. The T.M.S. (Teorell, Meyer, Sievers) theory was applied to these systems for the treatment of experimental data. The results show that, in the basement membrane, the density of fixed charges such as ionogenic groups encountered in heparan sulfate proteoglycan is low. The ratios of the mobilities from the chloride anion and the alkaline cation are different to those in water. In this type of membrane, the mobility of Cl- is higher than the mobilities of K+, Na+ and Ca2+. This result leads us to investigate further the diffusion problem of electrolytes through basement membrane.

Preparation and characterization of a glycyl-l-methioninatocopper(II) complex

SummaryA glycyl-L-methioninatocopper(II) complex has been isolated and characterized using x-ray crystallography. Precise details are given about its preparation. Crystal parameters have been determined.