Gerhard Frisch
Hoffmann-La Roche
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Featured researches published by Gerhard Frisch.
Journal of diabetes science and technology | 2013
Eva Zschornack; Christina Schmid; Stefan Pleus; Manuela Link; Hans-Martin Klötzer; Karin Obermaier; Michael Schoemaker; Monika Strasser; Gerhard Frisch; Günther Schmelzeisen-Redeker; Cornelia Haug; Guido Freckmann
Background: The performance of a continuous glucose monitoring (CGM) system in the early stage of development was assessed in an inpatient setting that simulates daily life conditions of people with diabetes. Performance was evaluated at low glycemic, euglycemic, and high glycemic ranges as well as during phases with rapid glucose excursions. Methods: Each of the 30 participants with type 1 diabetes (15 female, age 47 ± 12 years, hemoglobin A1c 7.7% ± 1.3%) wore two sensors of the prototype system in parallel for 7 days. Capillary blood samples were measured at least 16 times per day (at least 15 times per daytime and at least once per night). On two subsequent study days, glucose excursions were induced. For performance evaluation, the mean absolute relative difference (MARD) between CGM readings and paired capillary blood glucose readings and precision absolute relative difference (PARD), i.e., differences between paired CGM readings were calculated. Results: Overall aggregated MARD was 9.2% and overall aggregated PARD was 7.5%. During induced glucose excursions, MARD was 10.9% and PARD was 7.8%. Lowest MARD (8.5%) and lowest PARD (6.4%) were observed in the high glycemic range (euglycemic range, MARD 9.1% and PARD 7.4%; low glycemic range, MARD 12.3% and PARD 12.4%). Conclusions: The performance of this prototype CGM system was, particularly in the hypoglycemic range and during phases with rapid glucose fluctuations, better than performance data reported for other commercially available systems. In addition, performance of this prototype sensor was noticeably constant over the whole study period. This prototype system is not yet approved, and performance of this CGM system needs to be further assessed in clinical studies.
Archive | 2010
Wolfgang Heck; Bernd Roesicke; Gerhard Frisch
Archive | 2012
Timothy Peter Engelhardt; Gerhard Frisch; Robert E. Reinke; Wilfried Schmidt; Michael Schoemaker; Uwe Wittmann
Archive | 2012
Nikolaus Schmitt; Gerhard Frisch
Archive | 2011
Robert E. Reinke; Phillip E. Pash; James R. Long; Guido Konrad; Erich Imhof; Gerhard Frisch
Archive | 2009
Nikolaus Schmitt; Gerhard Frisch
Archive | 2010
Karl Miltner; Thorsten Baeter; Gerhard Frisch; Sebastian Liedtke; Wilfried Schmid; Wolfgang Heck
Archive | 2010
Timothy Peter Engelhardt; Guenter Handwerker; Mark Nierzwick; Gerhard Frisch; Phillip E. Pash
Archive | 2011
Sebastian Liedtke; Thorsten Baeter; Gerhard Frisch; Lydia Kolonko; Craig Wightman; Mike Unwin
Archive | 2008
Karl Miltner; Sebastian Liedtke; Thorsten Baeter; Wilfried Schmid; Gerhard Frisch; Wolfgang Heck