Gerrit J. Kemerink

Patient and occupational dose in neurointerventional procedures

Neurointerventional procedures can involve very high doses of radiation to the patient. Our purpose was to quantify the exposure of patients and workers during such procedures, and to use the data for optimisation. We monitored the coiling of 27xa0aneurysms, and embolisation of four arteriovenous malformations. We measured entrance doses at the skull of the patient using thermoluminescent dosemeters. An observer logged the dose-area product (DAP), fluoroscopy time and characteristics of the digital angiographic and fluoroscopic projections. We also measured entrance doses to the workers at the glabella, neck, arms, hands and legs. The highest patient entrance dose was 2.3xa0Gy, the average maximum entrance dose 0.9±0.5xa0Gy. The effective dose to the patient was estimated as 14.0±8.1xa0mSv. Other average values were: DAP 228±131xa0Gy cm2, fluoroscopy time 34.8±12.6xa0min, number of angiographic series 19.3±9.4 and number of frames 267±143. The highest operator entrance dose was observed on the left leg (235±174xa0µGy). The effective dose to the operator, wearing a 0.35xa0mm lead equivalent apron, was 6.7±4.6xa0µSv. Thus, even the highest patient entrance dose was in the lower part of the range in which nonstochastic effects might arise. Nevertheless, we are trying to reduce patient exposure by optimising machine settings and clinical protocols, and by informing the operator when the total DAP reaches a defined threshold. The contribution of neurointerventional procedures to occupational dose was very small.

Reproducibility of spirometrically controlled CT lung densitometry in a clinical setting

The aim of this study was to assess the reproducibility of quantitative, spirometrically gated computed tomographic (CT) lung densitometry at defined levels of inspiration in hospitalized patients. On two consecutive days, spirometrically gated CT sections were obtained from 20 hospitalized patients at 5 cm above and 5 cm below the carina, and at 90 and 10% of the vital capacity (VC). The mean, modal and median lung densities were calculated, the cut-off points of the frequency distribution of Hounsfield units (HU) defining the lowest and the highest 10th percentile, as well as the histogram full width at half maximum. The lung density parameters of corresponding CT sections of both studies were compared. Reproducibility was expressed as the standard deviation of the signed difference between the results of Day 1 and Day 2 divided by the square root of 2. Reproducibility data were correlated with results of airflow limitation. At 90% VC, reproducibility was of the order of 3-14 HU in both lung zones. At 10% VC, reproducibility was worse by approximately a factor of three. No relationship was found between reproducibility and results of airflow limitation. In conclusion, objective measurement of lung density at spirometrically controlled levels of inspiration is a reproducible method in assessing pulmonary density. Reproducibility of lung density measurements is not influenced by severe respiratory insufficiency. The most reproducible computed tomographic lung density measurements can be obtained at 90% vital capacity.

CT densitometry of the lungs : scanner performance

OBJECTIVEnOur goal was to establish the reproducibility and accuracy of the CT scanner in densitometry of the lungs.nnnMATERIALS AND METHODSnScanner stability was assessed by analysis of daily quality checks. Studies using a humanoid phantom and polyethylene foams for lung were performed to measure reproducibility and accuracy. The dependence of the CT-estimated density on reconstruction filter, zoom factor, slice thickness, table height, data truncation, and objects outside the scan field was determined.nnnRESULTSnStability of the system at air density was within approximately 1 HU and at water density within approximately 2 HU. Reproducibility and accuracy for densities found for lung were within 2-3%. Dependence on the acquisition and reconstruction parameters was neglible, with the exceptions of the ultra high resolution reconstruction algorithm in the case of emphysema, and objects outside the scan field.nnnCONCLUSIONnThe performance of the CT scanner tested is quite adequate for densitometry of the lungs.

Calcium scores and matrix Gla protein levels: association with vitamin K status

Eur J Clin Invest 2010; 40 (4): 344–349

Patient dosimetry in abdominal arteriography

This study aims at accurate quantification of x-ray exposure and effective dose to the patient in abdominal arteriography. Using an automatic monitoring system, all relevant exposure parameters were determined during 172 abdominal arteriographies. Common projections were extracted for a normal reference group of procedures and used in Monte Carlo calculations of dose-area product to organ dose conversion coefficients. Dose-area product, organ doses and effective dose were quantified for intravenous and intra-arterial procedures. The large data sets describing exposure could be condensed to a set of 28 common views. New coefficients to convert dose area product to organ equivalent dose and effective dose were calculated for nine views contributing approximately 80% to the total dose-area product. The average dose-area product was 32 Gy cm2 in intravenous procedures and 47 Gy cm2 in intra-arterial procedures. The corresponding average effective doses to the patient were 4 mSv and 6 mSv respectively (range 2-12 mSv, actual value depending on procedure type and gender). It is concluded that automatic monitoring of x ray exposure parameters, complemented by the calculation of Monte Carlo organ dose conversion coefficients, is a feasible and promising approach to accurate dosimetry of complex arteriographic procedures.

Plantar pressure and sole thickness of the forefoot.

Background: Based on earlier observations that the forefoot bears the highest plantar pressure at its center, the existence of a functional distal transverse arch in normal feet was denied, and plantar pressure was defined as merely the outcome of loading, surface area, and soft tissue. Although plantar pressure drives the changes in the foot, neither the position nor the behavior of the metatarsals during loading can be derived from plantar pressure alone. In light of this, our goal was to describe the changes in thickness in the sole and the corresponding plantar pressure during loading of the foot. Methods: We used CT to image the foot of 10 subjects in four postures that were chosen to imitate four phases in the walking cycle. Before imaging we also recorded the plantar pressure with a pressure measuring insole on which the subjects were standing. From the data, the minimal thickness of the sole and the corresponding plantar pressure were derived. Results: With the exception of the sesamoids, the thickness of the sole under the bones of the forefoot increased from lateral to medial. This persisted in all postures. Our pressure readings matched previously reported distributions. Conclusions: Depending on the point of view concerning the sesamoids, the bony prominences were placed in a geometrical arch; but they did not form a functional arch. The soft tissue underneath the heads kept the metatarsals in place; the soft-tissue thickness reflected the principle of adequate cushioning.

The Intermetatarsal and Metatarsal Declination Angles: Geometry as a Source of Error

Background: The measurements on radiographs of the foot are believed to give an objective impression of foot deformities. In patient management, the outcome of these measurements is one of the factors that the physician takes into consideration. In fact, the radiograph is a projection of three-dimensional structures and is as such liable to a certain amount of distortion. To our knowledge this distortion has not been quantified, although it seems important for the interpretation of the measurements. Methods: First, mathematical models based on the geometry of standard anteroposterior and lateral radiographs were constructed and analyzed. Then, we simulated radiography with these models on three-dimensional data of metatarsals originating from CT scans of 10 normal volunteers. Results: The distortion of the declination angles of the metatarsals was practically negligible. The intermetatarsal angles were distorted up to 5.4 degrees. The measured angles underestimated the three-dimensional angles. Conclusions: In interpreting the measurements of the metatarsal declination angles, distortion was not a factor. For intermetatarsal angles variability of distortion was only about one third of the reported interobserver variability, but it may have cumulative effects on the error of measured intermetatarsal angles. Moreover, the theoretical models predicted larger distortions in patients with deformities. In interpretation of angular measurements the physician should be aware of these pitfalls.

Radiation Exposure of Abdominal Cone Beam Computed Tomography

PurposeTo evaluate patients radiation exposure of abdominal C-arm cone beam computed tomography (CBCT).MethodsThis prospective study was approved by the institutional review board; written, informed consent was waived. Radiation exposure of abdominal CBCT was evaluated in 40 patients who underwent CBCT during endovascular interventions. Dose area product (DAP) of CBCT was documented and effective dose (ED) was estimated based on organ doses using dedicated Monte Carlo simulation software with consideration of X-ray field location and patients’ individual body weight and height. Weight-dependent ED per DAP conversion factors were calculated. CBCT radiation dose was compared to radiation dose of procedural fluoroscopy. CBCT dose-related risk for cancer was assessed.ResultsMean ED of abdominal CBCT was 4.3xa0mSv (95xa0% confidence interval [CI] 3.9; 4.8xa0mSv, range 1.1–7.4xa0mSv). ED was significantly higher in the upper than in the lower abdomen (pxa0=xa00.003) and increased with patients’ weight (rxa0=xa00.55, slopexa0=xa00.045xa0mSv/kg, pxa0<xa00.001). Radiation exposure of CBCT corresponded to the radiation exposure of on average 7.2 fluoroscopy minutes (95xa0% CI 5.5; 8.8xa0min) in the same region of interest. Lifetime risk of exposure related cancer death was 0.033xa0% or less depending on age and weight.ConclusionsMean ED of abdominal CBCT was 4.3xa0mSv depending on X-ray field location and body weight.

Effect of tube angulation on the measurement of intermetatarsal angles.

We systematically investigated the effect of tube angulation on angular distortion of the anteroposterior radiograph of the foot. Three-dimensional data from the metatarsals originating from computed tomographic scans of ten healthy volunteers were projected onto the supporting surface at various tube angulations to simulate radiography. The distortion of the intermetatarsal angles decreased from 1.2 degrees to 3.5 degrees at 20 degrees tube angulation to 0.4 degrees to 2.7 degrees at 0 degrees tube angulation. The relatively small improvement in angular measurement using 0 degrees instead of 15 degrees tube angulation would not outweigh the adverse effects of changing the standard radiographic technique. Physician awareness of this source of error when planning surgical therapy seems more important.

Vascular radiology in the Netherlands in 1992: A quantitative approach

A survey was held into methods and extent of vascular radiology in the Netherlands. For the year 1992, quantitative data on the number of patients, vascular radiological examinations and characteristics of angiography facilities were obtained from more than 80% of the Dutch hospitals with angiography rooms (120). The following estimates have been inferred: approximately 50,600 patients were referred for non-cardiac vascular radiology, including 32,100 patients for intra-arterial arteriography, 8900 for intravenous DSA arteriography, 4600 for phlebography and 5000 for interventional radiology. On average about two vascular examinations were carried out per patient referred for arteriography. In interventional radiology, the number of patients and the number of examinations are quite similar. The total number of angiography rooms in the Netherlands was 136. The average age of angiography X-ray systems was 7.1 years, of imaging equipment 5.7 years. In 56% of the hospitals, the X-ray tube was normally applied in the undercouch position, in 40% in overcouch position and in 4% there was no preferred position. An additional survey of occupational exposure conditions in angiography rooms (19 hospitals) showed that, in most hospitals, protective lead aprons of 0.5 mm Pb-equivalent were in use. Thyroid collars were used rather infrequently.