Ghanima Maassarani
University of Nevada, Reno
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Publication
Featured researches published by Ghanima Maassarani.
American Journal of Reproductive Immunology | 1998
Geoffrey Sher; William Matzner; Michael Feinman; Ghanima Maassarani; Christo Zouves; Penny Chong; Wendell Ching
PROBLEM: The effect of mini‐dose heparin/aspirin (H/A) alone vs. combined intravenous immunoglobulin G (IVIg) and H/A on in vitro fertilization (IVF) birthrates in women who test seropositive for antiphospholipid antibodies (APA+) was evaluated, as was the question of whether outcome is influenced by the gammaglobulin isotype(s) or the phospholipid (PL) epitope(s) to which the APAs are directed.
American Journal of Reproductive Immunology | 1998
Geoffrey Sher; Christo Zouves; Ghanima Maassarani; Michael Feinman; William Matzner; Penny Chong; Wendell Ching
PROBLEMS: 1) Does the administration of heparin and aspirin (H/A) in combination with intravenous immunoglobulin G (IVIG) improve in vitro fertilization (IVF) implantation and birth rates in patients with recurrent IVF failures? 2) Is the effect of such treatment related to the antiphospholipid antibody (APA) status of the patients concerned?
American Journal of Reproductive Immunology | 1998
Geoffrey Sher; Ghanima Maassarani; Christo Zouves; Michael Feinman; Sae Sohn; William Matzner; Penny Chong; Wendell Ching
PROBLEM: To compare the effect of heparin/aspirin therapy alone vs. heparin/aspirin in combination with intravenous immuno‐globulin (IVIg) immunotherapy on in vitro fertilization (IVF) outcome of patients who test positive for antithyroid antibodies (ATAs).
Fertility and Sterility | 2009
Geoffrey Sher; L. Keskintepe; Meral Keskintepe; Ghanima Maassarani; Drew Tortoriello; Steven A. Brody
OBJECTIVE To assess the benefit of selecting blastocysts for cryotransfer based upon prior comparative genomic hybridization (CGH) karyotyping of blastomeres derived from their cleaved embryos of origin. Implantation and birth rates per transfer of previtrified CGH-tested blastocysts were compared with those following the transfer of nonCGH-tested fresh and warmed embryos. DESIGN In vitro studies. SETTING Private infertility clinic. PATIENT(S) Women undergoing infertility treatment. INTERVENTION(S) Three groups of women with similar clinical and demographic characteristics were compared. Group A underwent transfer of warmed blastocysts derived from CGH-normal day 3 embryos. Group B underwent embryo transfer of warmed blastocysts derived from nonkaryotyped vitrified embryos. Group C underwent fresh transfers with non-CGH-tested blastocysts. MAIN OUTCOME MEASURE(S) Implantation and birth rates per embryo after the cryotransfer of CGH-tested blastocysts. RESULT(S) The birth rate per transferred blastocyst in group A was 48%, versus 15% for group B and 19% for group C. The birth rate per embryo transfer was 60% for group A, and 33% for group B and 36% for group C. The miscarriage rate was 4% in group A, 8% in group B, and 12% in group C. CONCLUSION(S) The transfer of previously vitrified blastocysts derived from CGH-normal embryos significantly improves implantation and birth rates per embryo transferred and reduces the miscarriage rate. Vitrification does not compromise this enhancement.
Fertility and Sterility | 2009
L. Keskintepe; Yuksel Agca; Geoffrey Sher; Meral Keskintepe; Ghanima Maassarani
OBJECTIVE To use metaphase II (MII) bovine oocytes as a model for MII human oocyte cryopreservation and to determine the effect of different previtrification equilibration temperatures, vitrification solutions, zona slitting, and first polar body biopsy on in vitro and in vivo developmental competence of MII human oocytes after the CryoLoop vitrification method. DESIGN In vitro and in vivo studies. SETTING A private infertility clinic. PATIENT(S) Women undergoing infertility treatment. INTERVENTION(S) Metaphase II stage bovine and MII human oocytes underwent first polar body biopsy before cryopreservation in different vitrification conditions, and human oocytes were fertilized by intracytoplasmic sperm injection after warming. The resulting embryos were transferred into women undergoing infertility treatment. MAIN OUTCOME MEASURE(S) Postvitrification morphologic survival, in vitro blastocyst development, and clinical outcome after ET. RESULT(S) The equilibration temperature had a significant effect on cryosurvival of both bovine and human oocytes. High (97%-99%) postvitrification survival was achieved for both MII bovine and human oocytes, and high fertilization (90%-97%) at 35 degrees C to 37 degrees C, blastocyst development (18%-45%), and pregnancy (50%) rates were achieved at 35 degrees C with 5.0 mol/L ethylene glycol + 1.3 mol/L dimethyl sulfoxide for MII human oocytes that underwent first polar body biopsy. CONCLUSION(S) Previtrification equilibration temperature had a profound effect on the postthaw developmental competence of MII human oocytes in vitro and in vivo. The CryoLoop vitrification of first polar body-biopsied MII human oocytes in the presence of 5 mol/L ethylene glycol plus 1.3 mol/L dimethyl sulfoxide gave the best results in terms of fertilization, embryo development, and implantation rates.
Human Reproduction | 1994
Geoffrey Sher; Michael Feinman; Christo Zouves; Gordon Kuttner; Ghanima Maassarani; Rifaat Salem; William Matzner; Wendell Ching; Penny Chong
Human Reproduction | 1995
Geoffrey Sher; Christo Zouves; M. Feinman; Ghanima Maassarani
Human Reproduction | 1993
Geoffrey Sher; S. Dodge; Ghanima Maassarani; V. Knutzen; Christo Zouves; Michael Feinman
Human Reproduction | 2000
Geoffrey Sher; Jeffrey D. Fisch; Ghanima Maassarani; William Matzner; Wendell Ching; Penny Chong
Archive | 2004
Geoffrey Sher; Ghanima Maassarani