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Publication
Featured researches published by Giampiero Spalluto.
Tetrahedron Letters | 1990
Achille Barco; Simonetta Benetti; Alberto Casolari; Gian Piero Pollini; Giampiero Spalluto
Abstract A convergent one-pot construction of disubstituted pyrrolidine and piperidine frameworks has been accomplished through a simple protocol involving intermolecular conjugate addition of a nitrogen nucleophile to an electrophilic olefin followed by intramolecular trapping of the generated enolate by a built-in α,β,-unsaturated acceptor.
Tetrahedron Letters | 1990
Achille Barco; Simonetta Benetti; Alberto Casolari; Gian Piero Pollini; Giampiero Spalluto
Abstract A concise enantioselective route to (+)- and (−)-a-allokainic acid from D- and L-serine respectively has been established by enantio- and diastereo-selective tandem Michael reaction methodology for the construction of three chiral centers in a single stage.
Tetrahedron Letters | 1991
Achille Barco; Simonetta Benetti; Gian Piero Pollini; Giampiero Spalluto; Vinicio Zanirato
Abstract Two procedures for the regiospecific preparation of 3-substituted-2-nitro-1,3-dienes have been developed. The cycloaddition chemistry of the in situ generated dienes has been investigated.
Tetrahedron Letters | 1993
Achille Barco; Simonetta Benetti; Carmela De Risi; Gian Piero Pollini; Giampiero Spalluto; Vinicio Zanirato
Abstract The anion of the title compound, simply generated in the presence of catalytic amount of triethylamine, acts as nucleophilic acylating equivalent of formaldehyde reacting with both common electrophilic olefins or aldehydes to give moderate to good yield of Michael or aldol adducts respectively, which are easily hydrolized by dilute acid at ambient to temperature to afford the corresponding aldehydes.
Journal of The Chemical Society, Chemical Communications | 1991
Achille Barco; Simonetta Benetti; Gian Piero Pollini; Giampiero Spalluto; Vinicio Zanirato
The enantioselective synthesis of a 2,3,4-trisubstituted pyrrolidine featuring the kainoid C-2, C-3 trans, C-3, C-4 cis arrangement of substituents has been accomplished through a tandem Michael reaction strategy involving 2-nitro-3-methylbuta-1,3-diene as electrophilic alkene, the removable electron-withdrawing group acting as a template for control of the stereochemistry of the cyclization, together with a secondary benzylamine incorporating a chiral centre at the carbon bearing the nitrogen nucleophile and an appropriate α,β-unsaturated acceptor able to trap the initially formed nitronate.
Journal of Organic Chemistry | 1992
Achille Barco; Simonetta Benetti; Giampiero Spalluto; Alberto Casolari; Gian Piero Pollini; Vinicio Zanirato
ChemInform | 1995
Simonetta Benetti; Romeo Romagnoli; C. De Risi; Giampiero Spalluto; Vinicio Zanirato
Synthesis | 1991
Achille Barco; Simonetta Benetti; Gian Piero Pollini; Giampiero Spalluto
Farmaco | 1991
Achille Barco; Simonetta Benetti; Giampiero Spalluto; Alberto Casolari; Gian Piero Pollini; Vinicio Zanirato; Pier Giovanni Baraldi
ChemInform | 2010
Simonetta Benetti; Romeo Romagnoli; Giampiero Spalluto