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Dive into the research topics where Gideon Goldstein is active.

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Featured researches published by Gideon Goldstein.


Digestive Diseases and Sciences | 1966

Response to azathioprine in ulcerative colitis: Report of 7 cases

Ian R. Mackay; A. J. Wall; Gideon Goldstein

SummaryUlcerative colitis is considered to be the result of an immunopathological reaction in the wall of the colon. Hence 7 patients with ulcerative colitis, including 2 with extracolonic features, were treated with the immunosuppressive drugs 6-mercaptopurine and azathioprine, mostly on a long-term basis. Six of the 7 patients showed varying degrees of clinical improvement. The most noteworthy effect was a striking decrease in lymphoid infiltration in the rectal mucosa.


Cellular Immunology | 1982

Surface antigen changes occurring in short-term cultures of activated human T lymphocytes: Analysis by flow cytometry

Gordon F. Burns; Francis L. Battye; Gideon Goldstein

Abstract Surface antigens of activated and cultured human T cells were studied using peripheral blood lymphocytes activated with conditioned medium from phytohemagglutinin-activated leukocytes and maintained in liquid culture for 2 weeks with conditioned medium containing Interleukin 2. The ensuing cell population was tested for kinetic changes in cell size and for the expression of surface antigens by immunofluorescence staining with a panel of monoclonal antibodies and analysis by flow cytometry. Upon activation, the cell population progressively increased in size to large blasts, with the rapid appearance on all of the large dividing cells of the antigen recognized by OKT9, the transferrin receptor. Cells within the population continued to express the common peripheral T-cell antigens bound by OKT3 and UCHT1, and also the antigen bound by 3A1, but never the antigen bound by OKT6, a thymic cell marker. From the time of activation an increasing proportion of the T cells, up to 80%, expressed the antigen detected with OKIa and FMC4, which recognise nonpolymorphic Ia determinants. This sequence of events was followed by a general decrease in size of the cell population, a process accompanied by further phenotypic changes. The percentage of cells expressing Ia antigens decreased, but most striking was the rapid change in the OKT4:OKT8 ratio of cells within the population, from 60:40 to 40:60. Thereafter the proportions of OKT4 + to OKT8 + cells within the cultures remained relatively stable and it is suggested that these data provide evidence for a possible change in phenotype of cultured human T lymphoblasts, from OKT4 to OKT8.


The Lancet | 1966

Experimental autoimmune thymitis. An animal model of human myasthenia gravis.

Gideon Goldstein; Senga Whittingham


The Lancet | 1966

THYMITIS AND MYASTHENIA GRAVIS

Gideon Goldstein


Immunology and Cell Biology | 1965

CONTRASTING ABNORMALITIES IN THE THYMUS IN SYSTEMIC LUPUS ERYTHEMATOSUS AND MYASTHENIA GRAVIS: A QUANTITATIVE HISTOLOCICAL STUDY

Gideon Goldstein; Ian R. Mackay


Journal of Experimental Medicine | 1966

Immunoglobulin isoantigens (allotypes) in the mouse. II. Allotypic analysis of three gammaG2-myeloma proteins from (NZB x BALB/c)F1 hybrids and of normal gammaG2-globulins.

Noel L. Warner; Leonard A. Herzenberg; Gideon Goldstein


Immunology and Cell Biology | 1966

Plasma cells in the human thymus.

Gideon Goldstein


Journal of the National Cancer Institute | 1966

Plasma-Cell Tumor Induction in (NZB × BALB/c)F1 Hybrid Mice

Gideon Goldstein; Noel L. Warner; Margaret C Holmes


Immunology and Cell Biology | 1966

MAST CELLS IN THE HUMAN THYMUS

Gideon Goldstein


Australian and New Zealand Journal of Surgery | 1967

Host resistance to cancer.

Gideon Goldstein

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Ian R. Mackay

Walter and Eliza Hall Institute of Medical Research

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A. J. Wall

Walter and Eliza Hall Institute of Medical Research

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Francis L. Battye

Walter and Eliza Hall Institute of Medical Research

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Gordon F. Burns

Walter and Eliza Hall Institute of Medical Research

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Ian J. Wood

Walter and Eliza Hall Institute of Medical Research

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Margaret C Holmes

Walter and Eliza Hall Institute of Medical Research

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Senga Whittingham

Walter and Eliza Hall Institute of Medical Research

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