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Dive into the research topics where Gideon Gross is active.

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Featured researches published by Gideon Gross.


Annual Review of Pharmacology and Toxicology | 2016

Therapeutic Potential of T Cell Chimeric Antigen Receptors (CARs) in Cancer Treatment: Counteracting Off-Tumor Toxicities for Safe CAR T Cell Therapy

Gideon Gross; Zelig Eshhar

A chimeric antigen receptor (CAR) is a recombinant fusion protein combining an antibody-derived targeting fragment with signaling domains capable of activating T cells. Recent early-phase clinical trials have demonstrated the remarkable ability of CAR-modified T cells to eliminate B cell malignancies. This review describes the choice of target antigens and CAR manipulations to maximize antitumor specificity. Benefits and current limitations of CAR-modified T cells are discussed, with a special focus on the distribution of tumor antigens on normal tissues and the risk of on-target, off-tumor toxicities in the clinical setting. We present current methodologies for pre-evaluating these risks and review the strategies for counteracting potential off-tumor effects. Successful implementation of these approaches will improve the safety and efficacy of CAR T cell therapy and extend the range of cancer patients who may be treated.


Proceedings of the National Academy of Sciences of the United States of America | 1993

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

Zelig Eshhar; Tova Waks; Gideon Gross; Daniel G. Schindler


Proceedings of the National Academy of Sciences of the United States of America | 1989

Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity

Gideon Gross; Tova Waks; Zelig Eshhar


Archive | 1993

Chimeric receptor genes and cells transformed therewith

Zelig Eshhar; Daniel G. Schindler; Tova Waks; Gideon Gross


Archive | 1993

Endowing lymphocytes with antibody specificity

Zelig Eshhar; Gideon Gross; Tova Waks


Archive | 1989

Endowing cells with antibody specificity

Zelig Eshhar; Gideon Gross; Tova Waks


Biochemical Society Transactions | 1995

Chimaeric T-cell receptors specific to a B-lymphoma idiotype: a model for tumour immunotherapy.

Gideon Gross; Shoshana Levy; Ronald Levy; Tova Waks; Zelig Eshhar


Cancer Journal | 2014

The emergence of T-bodies/CAR T cells.

Zelig Eshhar; Tova Waks; Gideon Gross


Methods | 1995

T-Bodies: Chimeric T-Cell Receptors with Antibody-Type Specificity

Zelig Eshhar; Gideon Gross; Tova Waks; Joseph Lustgarten; Nathan L. Bach; Anna Ratner; Jonathan Treisman; Daniel G. Schindler


Archive | 1993

Chimäre rezeptorgene und entsprechend damit transformierte zellen Chimeric receptor gene and thus suitably transformed cells

Zelig Eshhar; Gideon Gross; Daniel G. Schindler; Tova Waks

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Zelig Eshhar

Weizmann Institute of Science

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Tova Waks

Weizmann Institute of Science

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Daniel G. Schindler

Weizmann Institute of Science

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Anna Ratner

Weizmann Institute of Science

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Joseph Lustgarten

Weizmann Institute of Science

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Nathan L. Bach

Weizmann Institute of Science

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Jonathan Treisman

National Institutes of Health

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