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Dive into the research topics where Gilbert Stanley Staten is active.

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Featured researches published by Gilbert Stanley Staten.


Tetrahedron Letters | 1990

Asymmetric synthesis and absolute stereochemistry of LY248686

Jack B. Deeter; Jeff Frazier; Gilbert Stanley Staten; Mike Staszak; Leland Otto Weigel

Abstract Reduction of 3-(dialkylamino)-1-aryl-1-propanones with a 2:1 complex of [(2R,3S-(+)-4--dimethylamino-l,2-diphenyl-3-methyl-2-butanol] (8) and lithium aluminum hydride (LAH) provided the corresponding 1,3-aminoalcohols in high ees (80–88%). This process was developed and applied to the synthesis of LY248686 (1), a potent inhibitor of serotonin (5HT) and norepinephrine (NE) uptake. Absolute configurations have been established by single crystal x-ray analysis.


Archive | 1991

Chiral synthesis of 1-aryl-3-aminopropan-1-ols

Michael Alexander Staszak; Gilbert Stanley Staten; Leland Otto Weigel


Journal of Medicinal Chemistry | 1994

Total synthesis and biological properties of novel antineoplastic (chloromethyl)furanoindolines: an asymmetric hydroboration mediated synthesis of the alkylation subunits.

Fariborz Mohamadi; Michael M. Spees; Gilbert Stanley Staten; Philip Marder; Julia K. Kipka; David A. Johnson; Dale L. Boger; Hamideh Zarrinmayeh


Journal of Medicinal Chemistry | 1992

Leukotriene B4 receptor antagonists : the LY255283 series of hydroxyacetophenones

David K. Herron; Theodore Goodson; Nancy G. Bollinger; Dorothy Swanson-Bean; Ian G. Wright; Gilbert Stanley Staten; Alan R. Thompson; Larry L. Froelich; William T. Jackson


Archive | 1981

Herbicidal 2-methylamino thiadiazolines

Eddie Vi-Ping Tao; Gilbert Stanley Staten


Archive | 1990

SYNTHESIS OF 2-AMINOPYRIMIDO Û4,5-G¨ QUINOLINES

Leland Otto Weigel; Gilbert Stanley Staten


Archive | 1987

Synthesis of 2-aminopyrimido¬4,5-g|quinolines

Leland Otto Weigel; Gilbert Stanley Staten


Archive | 1988

7-phenylsulfonyloxymethylene-6-oxo-perhydroquinolines

Leland Otto Weigel; Gilbert Stanley Staten


Archive | 1993

SINTESIS DE 2-AMINOPIRIMIDINAS (4,5-G)-QUINOLINAS.

Leland Otto Weigel; Gilbert Stanley Staten


Archive | 1987

SYNTHESIS OF 2-AMINOPYRIDMIDO (4,5-G) QUINOLINES

Leland Otto Weigel; Gilbert Stanley Staten

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Dale L. Boger

Scripps Research Institute

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