Gilbert Stanley Staten

Archive Network Publication Hotspot Collaboration

Network

Latest external collaboration on country level. Dive into details by clicking on the dots.

Explore More

Hotspot

Dive into the research topics where Gilbert Stanley Staten is active.

Explore More

Publication

Featured researches published by Gilbert Stanley Staten.

Tetrahedron Letters | 1990

Asymmetric synthesis and absolute stereochemistry of LY248686

Jack B. Deeter; Jeff Frazier; Gilbert Stanley Staten; Mike Staszak; Leland Otto Weigel

Abstract Reduction of 3-(dialkylamino)-1-aryl-1-propanones with a 2:1 complex of [(2R,3S-(+)-4--dimethylamino-l,2-diphenyl-3-methyl-2-butanol] (8) and lithium aluminum hydride (LAH) provided the corresponding 1,3-aminoalcohols in high ees (80–88%). This process was developed and applied to the synthesis of LY248686 (1), a potent inhibitor of serotonin (5HT) and norepinephrine (NE) uptake. Absolute configurations have been established by single crystal x-ray analysis.

Archive | 1991

Chiral synthesis of 1-aryl-3-aminopropan-1-ols

Michael Alexander Staszak; Gilbert Stanley Staten; Leland Otto Weigel

Journal of Medicinal Chemistry | 1994

Total synthesis and biological properties of novel antineoplastic (chloromethyl)furanoindolines: an asymmetric hydroboration mediated synthesis of the alkylation subunits.

Fariborz Mohamadi; Michael M. Spees; Gilbert Stanley Staten; Philip Marder; Julia K. Kipka; David A. Johnson; Dale L. Boger; Hamideh Zarrinmayeh

Journal of Medicinal Chemistry | 1992

Leukotriene B4 receptor antagonists : the LY255283 series of hydroxyacetophenones

David K. Herron; Theodore Goodson; Nancy G. Bollinger; Dorothy Swanson-Bean; Ian G. Wright; Gilbert Stanley Staten; Alan R. Thompson; Larry L. Froelich; William T. Jackson

Archive | 1981