Giovanna Gatti
University of Perugia
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Featured researches published by Giovanna Gatti.
Annals of Surgery | 2005
Umberto Veronesi; Roberto Orecchia; Alberto Luini; Viviana Galimberti; Giovanna Gatti; Mattia Intra; Paolo Veronesi; Maria Cristina Leonardi; Mario Ciocca; Roberta Lazzari; Pietro Caldarella; Serife Simsek; Luzemira Santos Silva; Daniele Sances
Background:Previous studies show that local recurrences after breast-conserving treatment occur in the site of the primary tumor. The need for postoperative radiotherapy on the whole breast is challenged in favor of radiotherapy limited to the area of the breast at high risk of recurrence. The new mobile linear accelerators easily moved close to the operating table to allow the full-dose irradiation during surgery. Patients and Methods:From July 1999 to December 2003, 590 patients affected by unifocal breast carcinoma up to a diameter of 2.5 cm received wide resection of the breast followed by intraoperative radiotherapy with electrons (ELIOT). Most patients received 21 Gy intraoperatively, biologically equivalent to 58 to 60 Gy in standard fractionation. Patients were evaluated 1, 3, 6, and 12 months after surgery, and thereafter every 6 months, to look for early, intermediate, late complications, and other events. Results:After a follow-up from 4 to 57 months (mean, 24 months; median, 20 months), 19 patients (3.2%) developed breast fibrosis, mild in 18, severe in 1, which resolved within 24 months. Three patients (0.5%) developed local recurrences, 3 patients ipsilateral carcinomas in other quadrants and other 5 patients contralateral breast carcinoma. One patient (0.2%) died of distant metastases. Conclusions:ELIOT is a safe method for treating conservatively operated breasts, avoids the long period of postoperative radiotherapy, and reduces drastically the cost of radiotherapy. ELIOT reduces radiation to normal tissues and organs. Results on short-term and middle-term toxicity up to 5 years of follow-up are good. Data on local control are encouraging.
Breast Cancer Research and Treatment | 2007
A. Luini; Marisel Aguilar; Giovanna Gatti; Roberta Fasani; Edoardo Botteri; Jack Antonio Diaz Brito; Patrick Maisonneuve; Anna Rita Vento; Giuseppe Viale
BackgroundMetaplastic carcinoma of the breast is a rare form of breast cancer and has an uncertain prognostic significance. The purpose of the present study was to compare the clinical course, and prognosis, between this type of tumor and poorly differentiated ductal carcinoma.Patients and methodsWe analyzed 37 cases of metaplastic carcinoma of the breast treated at our institution (European Institute of Oncology in Milan, Italy) between 1997 and 2004, comparing them with 72 cases (control group) of poorly differentiated ductal carcinoma. All 109 patients had negative receptors and were G3 at final histology. The control cases were matched according to year of surgery, pT (pT1 vs. pT2/3/4), and pN (absent vs. present).ResultsOf the 37 patients, eleven died from disease progression, eight developed metastatic disease and two experienced local recurrence. In the control group (72 patients) we observed three deaths due to disease progression, 13 distant metastases, and two local recurrences.ConclusionThe overall survival in the metaplastic carcinoma group was significantly worse than in the control group. As regards to disease-free survival, there was no statistically significant difference between the two groups.
The Breast | 2003
Roberto Orecchia; Mario Ciocca; Roberta Lazzari; Cristina Garibaldi; M.C. Leonardi; A. Luini; M. Intra; Giovanna Gatti; Paolo Veronesi; J. I. Petit; U. Veronesi
Local recurrences after breast-conserving surgery occur mostly in the quadrant harbouring primary carcinoma. The main objective of postoperative radiotherapy should be the sterilisation of residual cancer cells in the operative area while irradiation of the whole breast may be avoided. We have developed a new technique of intraoperative radiotherapy of a breast quadrant after the removal of the primary carcinoma (ELIOT). A mobile linear accelerator with a robotic arm is utilised delivering electron beams able to produce energies from 3 to 9 MeV. Different dose levels were tested from 10 to 21 Gy without important side effects. A randomized trial is currently ongoing in order to compare conventional irradiation and ELIOT. More than 400 patients have been enrolled. In addition a new approach for nipple and areola complex conservation, including ELIOT, is under investigation.
Tumori | 2005
Giovanna Gatti; Stefano Zurrida; Daniela Gilardi; Guillermo Bassani; Gabriela Rosali dos Santos; A. Luini
Bladder metastases from solid tumors are rare. Breast carcinoma cells seldom spread to the urinary bladder. We report the case of a patient with invasive breast carcinoma who developed a breast recurrence followed by bone and urinary bladder metastases. Starting from this clinical case we review the available literature on this issue. Only few cases of urinary bladder metastases from primary breast cancer have been reported, although the case reports have increased in recent years. Patients with breast cancer presenting with urinary symptoms should be examined for possible bladder metastases.
Tumori | 2006
Giovanna Gatti; Giancarlo Pruneri; Daniela Gilardi; Fabricio Brenelli; Guillermo Bassani; A. Luini
Aims and background Pure ductal invasive carcinoma of the breast is more frequently associated with lymphatic invasion, lymph node involvement and high malignant histological grade than combined forms of breast carcinoma. Internal mammary node metastases are not frequently detected when the axillary nodes are negative. Patients and methods We report our experience of a case of pure cribriform carcinoma, associated with an intraductal cribriform component, in which the sentinel axillary nodes were negative, while nodal and perinodal metastasis was detected in one internal mammary lymph node. Conclusions Data from the literature show that positive internal mammary nodes are an unusual finding when the axillary sentinel node is negative, especially in cases of cancer with a relatively good prognosis, such as cribriform cases.
Surgery | 2006
Mattia Intra; Alberto Luini; Giovanna Gatti; Mario Ciocca; Oreste Gentilini; André A.C. Viana; Eduardo Malaquias Chagas; Anastasio Berrettini; Fernando Schuh; Daniela Scarpa; Roberto Orecchia; Umberto Veronesi
Annals of Oncology | 2005
Alberto Luini; Giovanna Gatti; Bettina Ballardini; S. Zurrida; Viviana Galimberti; Paolo Veronesi; Annarita Vento; Simonetta Monti; Giuseppe Viale; Giovanni Paganelli; U. Veronesi
The Breast | 2007
A. Luini; Giovanna Gatti; S. Zurrida; Nina Talakhadze; Fabricio Brenelli; Daniela Gilardi; Giovanni Paganelli; Roberto Orecchia; Enrico Cassano; Giuseppe Viale; Claudia Sangalli; Bettina Ballardini; Gabriela Rosali dos Santos; Umberto Veronesi
The Breast | 2004
Favio Bassi; Giovanna Gatti; E. Mauri; B. Ballardini; T. De Pas; Alberto Luini
Ecancermedicalscience | 2008
U. Veronesi; R Orrechia; A. Luini; Viviana Galimberti; Giovanna Gatti; Mattia Intra; Paolo Veronesi; Maria Cristina Leonardi; Mario Ciocca; Roberta Lazzari; Pietro Caldarella; N Rotmensz; C Sangalli; L Santos Silva; Daniele Sances