Giovanni Abrahão Salum Junior
Universidade Federal do Rio Grande do Sul
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Publication
Featured researches published by Giovanni Abrahão Salum Junior.
Trends in Psychiatry and Psychotherapy | 2013
Marianna de Abreu Costa; Giovanni Abrahão Salum Junior; Luciano Isolan; Jandira Rahmeier Acosta; Rafaela Behs Jarros; Carolina Blaya; Lisia von Diemen; Gisele Gus Manfro
BACKGROUND Anxiety disorders are highly prevalent, affecting approximately 10% of individuals throughout life; its onset can be detected since early childhood or adolescence. Studies in adults have shown that anxiety disorders are associated with alcohol abuse, but few studies have investigated the association between anxiety symptoms and problematic alcohol use in early ages. OBJECTIVE To evaluate if anxiety symptoms are associated with problematic alcohol use in young subjects. METHODS A total of 239 individuals aged 10-17 years were randomly selected from schools located in the catchment area of Hospital de Clínicas de Porto Alegre. The Screen for Child Anxiety-Related Emotional Disorders (SCARED) was used to evaluate the presence of anxiety symptoms, and the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST), to evaluate alcohol use. RESULTS One hundred twenty-seven individuals (53.1% ) reported having already used alcohol. Of these, 14 individuals showed problematic alcohol use (5.8% ). There was no association between lifetime use of alcohol and anxiety symptoms, but mean SCARED scores in individuals with problematic alcohol use was higher if compared to those without problematic use, even after adjustment for age and gender (29.9±8.5 vs. 23.7±11.8, p < 0.001). CONCLUSIONS Despite the limitation of a cross-sectional design, our study suggests that anxiety symptoms are associated with problematic alcohol use early in life.
European Neuropsychopharmacology | 2017
Leticia Maria Spindola; Pedro Mario Pan; Patricia N. Moretti; Vanessa Kiyomi Ota; Marcos Leite Santoro; Hugo Cogo-Moreira; Ary Gadelha; Giovanni Abrahão Salum Junior; Gisele Gus Manfro; Jair de Jesus Mari; Helena Brentani; Elisa Brietzke; Euripedes C. Miguel; Luis Augusto Rohde; João Ricardo Sato; Rodrigo Affonseca Bressan; Sintia Iole Belangero
Background Studies investigating major depressive disorder (MDD) in childhood and adolescence are relevant to understand relative contributions from either genetic and environmental factors on MDD, since early stages of disease have less influence of illness exposure. We aimed to investigate peripheral mRNA expression of 12 genes related to HPA axis (NR3C1, FKBP5), inflammation (TNF, TNFR1, TNFR2, IL1B), neurodevelopment (DISC1, PDE4B, QKI), and neurotransmission (SLC1A4, GLUL, COMT) in blood of children and adolescents with MDD and to test if history of childhood maltreatment (CM) or prenatal alcohol (PA) and tobacco (PT) exposure (environmental stressors that influences psychiatry disorders risk) could affect MDD via gene expression. Methods mRNA levels in whole blood were compared among 20 children and adolescents with MDD diagnosis (MDD group), 48 subjects without MDD diagnosis but with high levels of depressive symptoms (DS group) and 61 healthy controls (HC group). We also performed a mediation model in which CM/PA/PT exposure was the independent variable, MDD was the outcome and gene expression was the intermediary variable. Results NR3C1, TNF, TNFR1 and IL1B expression levels were significantly lower in MDD group compared to the other groups. The direct effects of CM, PA and PT exposure on MDD were not significant. Moreover, there was not an indirect effect of PA or PT exposure on MDD. However, there was an indirect effect on the aggregation of these four genes expressions, mediating the relationship between CM and MDD. Discussion In the largest study investigating gene expression in children with MDD, we demonstrated that the NR3C1, TNF, TNFR1 and IL1B expression are related to the MDD and conjunctly mediated the effect of history of CM on risk of developing the disorder, supporting a role of glucocorticoids and inflammation as possible effectors of environmental distress on this disorder.
Rev. HCPA & Fac. Med. Univ. Fed. Rio Gd. do Sul | 2008
Elizeth Heldt; Carolina Blaya Dreher; Letícia Kipper; Giovanni Abrahão Salum Junior; Gisele Gus Manfro
Archive | 2017
Luiza Kvitko Axelrud; Gisele Gus Manfro; Luis Augusto Paim Rohde; Giovanni Abrahão Salum Junior
Archive | 2017
Arthur Gus Manfro; Luis Augusto Paim Rohde; Giovanni Abrahão Salum Junior
Archive | 2016
Natan Pereira Gosmann; Christian Kieling; Guilherme Polanczyk; Luis Augusto Paim Rohde; Giovanni Abrahão Salum Junior
Archive | 2016
Luiza Kvitko Axelrud; Gisele Gus Manfro; Giovanni Abrahão Salum Junior
Archive | 2015
Rafael Massuti; Carlos Renato Moreira Maia; Flávia Wagner; Giovanni Abrahão Salum Junior; Luis Augusto Paim Rohde
Archive | 2015
Natan Pereira Gosmann; Gisele Gus Manfro; Luis Augusto Paim Rohde; Giovanni Abrahão Salum Junior
Archive | 2014
Patrícia Pelufo Silveira; Luciano Minuzzi; Alexandre Rosa Franco; Augusto Buchweitz; Gisele Gus Manfro; Giovanni Abrahão Salum Junior; Rudineia Toazza; Roberta Sena Reis; Tania Diniz Machado; Roberta Dalle Molle
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National Council for Scientific and Technological Development
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