Gisela Cristiane Ferraro

Alterações morfológicas e funcionais dos rins de cães com insuficiência renal crônica

Morphologic alterations of 11 cases of dogs with renal failure were characterized and classified according to the patterns established by the World Health Organization for human beings. Diffuse sclerosing glomerulonephritis was diagnosed in 82.0% of the animals and chronic interstitial nephritis in the remaining 18.0%. The types and frequencies of lesions were similar to the those noticed in the literature for chronic renal failure.

Propriedades mecânicas de três padrões de sutura no reparo de tendão do músculo flexor profundo do dedo em eqüinos

Four mechanical properties: Maximum Limit (ML), Elasticity Limit (EL), Rigidity (RG) and Resilience (RS), of three suture patterns, they were appraised, for mechanical tests of traction. Thirty tendons of the muscles deep digital flexores, of corpses of equine, were separate in three groups of equal number and approximate with the sutures of modified Kessler with suture in the epitendon (MK), modified Becker (MB) and double-locking loop (DL). The resistance to the space formation and the tension loss was also appraised. The results showed that for the load, in ML, only the suture pattern MK was shown significantly different (P<0,05); while, in PL, the three suture patterns behaved equally. As for the deformation, in ML and in EL, the three suture patterns presented significant differences amongst themselves (P<0,05). In RG, only MK behaved different (P<0,05). And, in RS, the three suture patterns presented significant differences amongst themselves (P<0,05). As for the failure, the pattern MK failed for distention and loss of the function of the suture, while the patterns suture MB and DL failed for rupture of the thread. The suture pattern MK was shown superior to the other ones two, whose mechanical properties were equivalent

Estudo morfológico de tendões flexores de eqüinos

A proposta deste estudo e a de descrever as caracteristicas morfologicas dos tendoes dos musculos flexores superficial (TMFSD) e profundo (TMFPD) dos dedos de equinos e focalizar suas diferencas. O material utilizado foi obtido de quatro segmentos tendineos colhidos dos membros toracicos e pelvicos, de sete cadaveres de equinos adultos sem lesoes macroscopicas diagnosticadas. Os segmentos examinados do TMFSD foram: juncao musculo-tendinea, terco medio do terceiro metacarpo ou metatarso, terco distal do terceiro metacarpo ou metatarso e extremidade distal da falange proximal. Por sua vez, para o TMFPD: juncao musculo-tendinea, regiao do terco medio do terceiro metacarpo ou metatarso, regiao do ligamento frenador inferior e regiao da falange media. Os resultados evidenciaram algumas diferencas histologicas na distribuicao e localizacao dos componentes entre segmentos do mesmo tendao e entre tendoes toracicos e pelvicos, especialmente para a quantidade de condrocitos, que mostrou ser maior na regiao do terco medio do terceiro metacarpo ou metatarso, tanto para os membros toracicos como para os pelvicos do TMFSD. No caso do TMFPD, o maior numero de tais celulas foi observado na regiao do terco medio do terceiro metacarpo dos membros toracicos e na regiao da falange media dos membros pelvicos.

Effect of snake venom derived fibrin glue on the tendon healing in dogs: clinical and biomechanical study

The aim of this study was to evaluate the effect of snake venom derived fibrin glue on the strength oftendon healing in dogs. The deep digital flexor tendon of the 5th digit of 24 thoracic limbs was partially sectioned for adhesive application. On the 7th, 15th, and 30th postoperative day tendons segments were removed for the clinical and biomechanical study. Results indicated that 62.5% of the tendons showed stump retraction and 20.8% moderate to excessive adherence, which affected gliding. The biomechanical evaluation showed that, over time, tendon healing gained progressive resistance for maximum traction and permanent deformations with satisfactory results on the 15th day for rigidity and resilience compared to the other two studied periods. Snake venom derived fibrin glue promotes healing in dog flexor tendon.

Clinical and morphological evaluation of snake venom derived fibrin glue on the tendon healing in dogs

The aim of this study was to evaluate the effect of snake venom derived fibrin glue on the healing of the deep digital flexor tendon, during three periods. The tendon of the 2nd digit of 30 thoracic limbs of dogs was partially sectioned for glue application. Biopsies were performed 7, 15, and 30 days post surgery for the clinical and morphological study of tendons. Analysis of the results showed that 73.3% of the tendons showed stump retraction and 16.6% moderate to excessive adherence, which affected sliding. There was a significant difference in the number of inflammatory cells among the three studied periods, being the highest on day 15. The morphological analysis revealed a typical tendon healing process with a lower level of inflammation in the acute phase, facilitating the cicatricial maturation phase. Snake venom derived fibrin glue promotes the healing in dog flexor tendon.

Propriedades mecânicas de três fios de sutura no reparo do tendão do músculo flexor profundo do dedo de cães

Considerando a complexidade da cicatrizacao tendinea e os fatores que interferem no fenomeno, o escopo desse trabalho foi o de avaliar comparativamente as diferencas nas propriedades biomecânicas dos materiais usualmente utilizados em tenorrafia. Para tanto tendoes dos musculos flexores profundo dos dedos de caes (TMFPD) foram colhidos de nove caes mesticos adultos que vieram a obito sem diagnostico de lesoes no aparelho locomotor. Os 18 TMFPD dos membros toracicos foram aleatoriamente selecionados em tres grupos e submetidos a tenotomia e tenorrafia utilizando fios Prolene®, Nylon® e Vicryl®. Para a sutura do epitendao utilizou-se fios de diâmetro 6.0 e para o endotendao 4.0. Os tendoes foram suturados com um desses materiais de sutura utilizando a tecnica de Kessler modificada. O estudo foi dividido em dois ensaios: Ensaio1: Os tendoes ensaiados foram testados na maquina universal de ensaios biomecânicos e as propriedades avaliadas foram: Limite Maximo (LM), Limite de Elasticidade (LE), Rigidez (RG) e Resiliencia (RS). Ensaio2: os fios de mononailon, acido poliglicolico e polipropileno nos diâmetros 6.0 e 4.0 foram testados isoladamente quanto as propriedades Limite Maximo (LM), Rigidez (RG) e Resiliencia (RS). Nas condicoes em que foi realizado o presente estudo os resultados permitem inferir que embora o Vicryl® tenha apresentado a maior rigidez, mostrou-se o mais apropriado para tenorrafias experimentais em caes, uma vez que em todas as outras propriedades biomecânicas apontou o melhor desempenho nos testes empregados.