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Dive into the research topics where Gisele R. Paim is active.

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Featured researches published by Gisele R. Paim.


Pharmacology, Biochemistry and Behavior | 2014

Antinociceptive effect of 3-(4-fluorophenyl)-5-trifluoromethyl-1H-1-tosylpyrazole. A Celecoxib structural analog in models of pathological pain

Sara Marchesan Oliveira; Cássia Regina Silva; Alexandre P. Wentz; Gisele R. Paim; Michele S. Correa; Helio G. Bonacorso; Arthur da Silveira Prudente; Michel Fleith Otuki; Juliano Ferreira

Pain is the most common complaint in the medical field and the identification of novel compounds that can effectively treat painful states without causing side effects remains a major challenge in biomedical research. The aim of the present study is to investigate the antinociceptive effect of 3-(4-fluorophenyl)-5-trifluoromethyl-1H-1-tosylpyrazole (FTosPz) in models of pathological pain in mice and compare these effects with those produced by Celecoxib. FTosPz (100-500 μmol/kg) or Celecoxib (26-260 μmol/kg) was administrated orally. The administration of either FTosPz or Celecoxib reduced the hyperalgesia but not the edema or leukocyte infiltration that was caused by Complete Freunds Adjuvant (CFA), used as an arthritis model. Oral administration of both FTosPz and Celecoxib also attenuated the postoperative hyperalgesia as well as the hyperalgesia caused by partial sciatic nerve ligation, used as a neuropathic pain model. FTosPz and Celecoxib produced antinociceptive effects without altering the locomotor activity of animals. Furthermore, FTosPz neither altered AST/ALT enzyme activity nor the urea/creatinine levels. Still, the FTosPz did not alter the COX-1 and COX-2 enzyme activities. Thus, FTosPz is an interesting prototype for the development of novel analgesic drugs.


Journal of Fluorine Chemistry | 2012

New trifluoromethyl-containing (E)-N′-arylidene-[3-alkyl(aryl/heteroaryl)-4,5-dihydro-1H-pyrazol-1-yl]carbohydrazides: Synthesis, crystal structure and antimicrobial/antioxidant activity

Helio G. Bonacorso; Susiane Cavinatto; Patrick T. Campos; Liliane M. F. Porte; Jussara Navarini; Gisele R. Paim; Marcos A. P. Martins; Nilo Zanatta; Caroline Z. Stüker


Tetrahedron Letters | 2009

DAST promotes the synthesis of new 5-(trifluoromethyl)-3-(1,1-difluoroethan-2-yl)-1H-pyrazoles

Helio G. Bonacorso; Liliane M. F. Porte; Cleber A. Cechinel; Gisele R. Paim; Everton D. Deon; Nilo Zanatta; Marcos A. P. Martins


Tetrahedron Letters | 2010

General method for dehydration, intramolecular cyclization, and fluorination of trifluoromethyl-1H-pyrazoles using DAST

Helio G. Bonacorso; Liliane M. F. Porte; Gisele R. Paim; Fábio M. Luz; Marcos A. P. Martins; Nilo Zanatta


Journal of Fluorine Chemistry | 2011

The first application of 4-alkoxy-1,1,1-trifluoroalk-3-en-2-ones in a three-component condensation protocol for the synthesis of 3-acyl-4-aryl-2-(trifluoromethyl)-2-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-ones

Helio G. Bonacorso; Jussara Navarini; Carson W. Wiethan; Guilherme P. Bortolotto; Gisele R. Paim; Susiane Cavinatto; Marcos A. P. Martins; Nilo Zanatta; Miguel S. B. Caro


Journal of the Brazilian Chemical Society | 2009

Synthesis of new trihalomethylated and non-symmetrical substituted 2-(1H-pyrazolyl)-5-(1H-pyrazolylcarbonyl)pyridines

Helio G. Bonacorso; Gisele R. Paim; Carolina Z. Guerra; Ronan C. Sehnem; Cleber A. Cechinel; Liliane M. F. Porte; Marcos A. P. Martins; Nilo Zanatta


Tetrahedron Letters | 2011

Chemoselective fluorination of 2-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-ones using DAST

Helio G. Bonacorso; Liliane M. F. Porte; Jussara Navarini; Gisele R. Paim; Fábio M. Luz; Lenon M. Oliveira; Carson W. Whietan; Marcos A. P. Martins; Nilo Zanatta


Arkivoc | 2012

6-Hydrazinonicotinic acid hydrazide: an useful precursor for chemo- and regioselective synthesis of new heteroaryl-linked pyridinohydrazones

Helio G. Bonacorso; Gisele R. Paim; Liliane M. F. Porte; Everton P. Pittaluga; Marcos A. P. Martins; Nilo Zanatta


Journal of Heterocyclic Chemistry | 2014

New Pyrazolyl‐Nicotinic Acids, Methyl Esters, and 1,3,4‐Oxadiazolyl‐pyrazolyl‐pyridine Tricyclic Scaffold Derivatives from 6‐Hydrazinylnicotinic Acid Hydrazide Hydrate

Helio G. Bonacorso; Gisele R. Paim; Liliane M. F. Porte; Everton P. Pittaluga; Susiane Cavinatto; Alexandre R. Meyer; Marcos A. P. Martins; Nilo Zanatta


Arkivoc | 2012

Regioselective synthesis and antimicrobial evaluation of new 1-aryloxyacetyl-, 1-thiophenoyacetyl- and 1-phenylaminoacetyl-substituted 3-alkyl(aryl/heteroaryl)-5-trifluoromethyl-5-hydroxy-4,5-dihydro-1H-pyrazoles

Helio G. Bonacorso; Everton P. Pittaluga; Sydney Hartz Alves; Larissa Finger Schaffer; Susiane Cavinatto; Liliane M. F. Porte; Gisele R. Paim; Marcos A. P. Martins; Nilo Zanatta

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Helio G. Bonacorso

Universidade Federal de Santa Maria

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Nilo Zanatta

Universidade Federal de Santa Maria

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Liliane M. F. Porte

Universidade Federal de Santa Maria

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Marcos A. P. Martins

Universidade Federal de Santa Maria

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Jussara Navarini

Universidade Federal de Santa Maria

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Everton P. Pittaluga

Universidade Federal de Santa Maria

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Susiane Cavinatto

Universidade Federal de Santa Maria

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Fábio M. Luz

Universidade Federal de Santa Maria

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Alexandre R. Meyer

Universidade Federal de Santa Maria

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Carson W. Wiethan

Universidade Federal de Santa Maria

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