Gisele R. Paim
Universidade Federal de Santa Maria
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Publication
Featured researches published by Gisele R. Paim.
Pharmacology, Biochemistry and Behavior | 2014
Sara Marchesan Oliveira; Cássia Regina Silva; Alexandre P. Wentz; Gisele R. Paim; Michele S. Correa; Helio G. Bonacorso; Arthur da Silveira Prudente; Michel Fleith Otuki; Juliano Ferreira
Pain is the most common complaint in the medical field and the identification of novel compounds that can effectively treat painful states without causing side effects remains a major challenge in biomedical research. The aim of the present study is to investigate the antinociceptive effect of 3-(4-fluorophenyl)-5-trifluoromethyl-1H-1-tosylpyrazole (FTosPz) in models of pathological pain in mice and compare these effects with those produced by Celecoxib. FTosPz (100-500 μmol/kg) or Celecoxib (26-260 μmol/kg) was administrated orally. The administration of either FTosPz or Celecoxib reduced the hyperalgesia but not the edema or leukocyte infiltration that was caused by Complete Freunds Adjuvant (CFA), used as an arthritis model. Oral administration of both FTosPz and Celecoxib also attenuated the postoperative hyperalgesia as well as the hyperalgesia caused by partial sciatic nerve ligation, used as a neuropathic pain model. FTosPz and Celecoxib produced antinociceptive effects without altering the locomotor activity of animals. Furthermore, FTosPz neither altered AST/ALT enzyme activity nor the urea/creatinine levels. Still, the FTosPz did not alter the COX-1 and COX-2 enzyme activities. Thus, FTosPz is an interesting prototype for the development of novel analgesic drugs.
Journal of Fluorine Chemistry | 2012
Helio G. Bonacorso; Susiane Cavinatto; Patrick T. Campos; Liliane M. F. Porte; Jussara Navarini; Gisele R. Paim; Marcos A. P. Martins; Nilo Zanatta; Caroline Z. Stüker
Tetrahedron Letters | 2009
Helio G. Bonacorso; Liliane M. F. Porte; Cleber A. Cechinel; Gisele R. Paim; Everton D. Deon; Nilo Zanatta; Marcos A. P. Martins
Tetrahedron Letters | 2010
Helio G. Bonacorso; Liliane M. F. Porte; Gisele R. Paim; Fábio M. Luz; Marcos A. P. Martins; Nilo Zanatta
Journal of Fluorine Chemistry | 2011
Helio G. Bonacorso; Jussara Navarini; Carson W. Wiethan; Guilherme P. Bortolotto; Gisele R. Paim; Susiane Cavinatto; Marcos A. P. Martins; Nilo Zanatta; Miguel S. B. Caro
Journal of the Brazilian Chemical Society | 2009
Helio G. Bonacorso; Gisele R. Paim; Carolina Z. Guerra; Ronan C. Sehnem; Cleber A. Cechinel; Liliane M. F. Porte; Marcos A. P. Martins; Nilo Zanatta
Tetrahedron Letters | 2011
Helio G. Bonacorso; Liliane M. F. Porte; Jussara Navarini; Gisele R. Paim; Fábio M. Luz; Lenon M. Oliveira; Carson W. Whietan; Marcos A. P. Martins; Nilo Zanatta
Arkivoc | 2012
Helio G. Bonacorso; Gisele R. Paim; Liliane M. F. Porte; Everton P. Pittaluga; Marcos A. P. Martins; Nilo Zanatta
Journal of Heterocyclic Chemistry | 2014
Helio G. Bonacorso; Gisele R. Paim; Liliane M. F. Porte; Everton P. Pittaluga; Susiane Cavinatto; Alexandre R. Meyer; Marcos A. P. Martins; Nilo Zanatta
Arkivoc | 2012
Helio G. Bonacorso; Everton P. Pittaluga; Sydney Hartz Alves; Larissa Finger Schaffer; Susiane Cavinatto; Liliane M. F. Porte; Gisele R. Paim; Marcos A. P. Martins; Nilo Zanatta