Gisho Honda

COUMARINS AND BICOUMARIN FROM FERULA SUMBUL: ANTI-HIV ACTIVITY AND INHIBITION OF CYTOKINE RELEASE

The methanol extract of the dried roots of Ferula sumbul afforded two furanocoumarin esters, fesumtuorin A, B, one bicoumarin, fesumtuorin C, five spirobicoumarins, fesumtuorin D, E, F, G and H, along with nineteen known coumarins. Their structures were established on the basis of spectroscopic studies. Some of the isolated compounds showed anti-HIV activity and very weak inhibition of cytokine release.

Sesquiterpenoids from the fruits of Ferula kuhistanica and antibacterial activity of the constituents of F. kuhistanica

Ethyl acetate extracts of the air-dried fruits of Ferula kuhistanica afforded three daucane esters: kuhistanicaol H, I and J, together with nine other known compounds. Their structures were established on the basis of spectroscopic evidence. Isolated compounds in this paper and previously reported compounds from the roots and stems of F. kuhistanica were tested for antibacterial activity. Some of them were selectively toxic against Gram-positive bacteria, including methicillin-sensitive and methicillin-resistant Staphylococcus aureus (MSSA and MRSA).

A bis-sesquiterpene and sesquiterpenolides from Inula macrophylla

Macrophyllidimer C, a novel bis-sesquiterpene, in which the two sesquiterpene units are directly connected by a C-C bond, and eight other sesquiterpenolides were obtained from the bark of Inula macrophylla. Seven of these, macrophyllilactones A-G, are new eudesmanolide- and elemanolide-type sesquiterpenes. Their structures were determined on the basis of spectroscopic evidence and chemical reaction.

Macrophyllidimers A and B, two novel sesquiterpene dimers from the bark of Inula macrophylla

Abstract Macrophyllidimers A and B, two novel sesquiterpene dimers in whose structures the two sesquiterpene units are connected by a C–C bond directly, have been isolated from the bark of Inula macrophylla. Their structures were determined on the basis of spectral evidence. The structure of macrophyllidimer B was finally confirmed by X-ray analysis. The possible biosynthetic pathways of macrophyllidimers A and B are also discussed.

An unusual sesquiterpene derivative from Ferula kuhistanica

An unusual new sesquiterpene derivative, kuhistaferone (1), was isolated from the fruits of the Uzbekistan medicinal plant Ferula kuhistanica. The structure of 1 was established on the basis of spectroscopic evidence. Compound 1 showed moderate cytotoxicity against the human colon tumor cell line HCT116.