Gk Whitfield
University of Arizona
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Featured researches published by Gk Whitfield.
Bone | 1995
Mark R. Haussler; Peter W. Jurutka; Jui-Cheng Hsieh; Paul D. Thompson; Sanford Selznick; Carol A. Haussler; Gk Whitfield
The nuclear vitamin D receptor (VDR) binds the 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]hormone with high affinity and elicits its actions to regulate gene expression in target cells by binding to vitamin D-responsive elements (VDREs). VDREs in positively controlled genes such as osteocalcin, osteopontin, beta 3-integrin, and vitamin D-24-OHase are direct hexanucleotide repeats with a spacer of three nucleotides. The VDR associates with these VDREs with the greatest affinity as a heterodimer with one of the family of retinoid X receptors (RXRs). VDR consists of an N-terminal zinc finger domain that determines DNA binding, a hinge segment and a C-terminal hormone binding domain which also contains two conserved regions that engage in heterodimerization with an RXR on the VDRE. The role of the 1,25(OH)2D3 ligand in transcriptional activation by the VDR-RXR heterodimer is to alter the conformation of the hormone-binding domain of VDR to facilitate strong dimerization with RXR, which results in ligand-enhanced association with the VDRE. Thus RXR is recruited into a heterocomplex by liganded VDR. The natural ligand for the RXR coreceptor, 9-cis retinoic acid, suppresses both VDR-RXR binding to the VDRE and 1,25(OH)2D3-stimulated transcription, indicating that 9-cis retinoic acid diverts RXR away from being the silent partner of VDR to instead form RXR homodimers. Recent data reveal that after binding RXR, a subsequent target for VDR in the vitamin D signal transduction cascade is basal transcription factor IIB (TFIIB).(ABSTRACT TRUNCATED AT 250 WORDS)
Molecular Endocrinology | 2000
Peter W. Jurutka; Lenore S. Remus; Gk Whitfield; Paul D. Thompson; Jui Cheng Hsieh; H. Zitzer; P. Tavakkoli; Michael A. Galligan; Hope Dang; Carol A. Haussler; Mark R. Haussler
Molecular Endocrinology | 1996
Gk Whitfield; Sanford Selznick; Carol A. Haussler; Jui-Cheng Hsieh; Michael A. Galligan; Peter W. Jurutka; Paul D. Thompson; S M Lee; J E Zerwekh; Mark R. Haussler
Journal of Biological Chemistry | 1991
Paul N. MacDonald; Carol A. Haussler; Christopher M. Terpening; Michael A. Galligan; M C Reeder; Gk Whitfield; Mark R. Haussler
Journal of Biological Chemistry | 1993
Peter W. Jurutka; Jui-Cheng Hsieh; Paul N. MacDonald; C. M. Terpening; Carol A. Haussler; Mark R. Haussler; Gk Whitfield
Molecular Endocrinology | 1995
Gk Whitfield; Jui-Cheng Hsieh; S. Nakajima; Paul N. MacDonald; Paul D. Thompson; Peter W. Jurutka; Carol A. Haussler; Mark R. Haussler
Journal of Molecular Endocrinology | 2001
Paul D. Thompson; Lenore S. Remus; Jui Cheng Hsieh; Peter W. Jurutka; Gk Whitfield; Michael A. Galligan; C Encinas Dominguez; Carol A. Haussler; Haussler
Journal of Nutrition | 1995
Gk Whitfield; Jui-Cheng Hsieh; Peter W. Jurutka; Sanford Selznick; Carol A. Haussler; Paul N. MacDonald; Mark R. Haussler
Archive | 2001
Pw Jurutka; Tl Lamb; Carlos Encinas Dominguez; Gk Whitfield; Jui-Cheng Hsieh; Paul Thompson; Michael A. Galligan; Carol A. Haussler; Haussler
Archive | 2002
Pw Jurutka; Paul Thompson; Gk Whitfield; Sm Myskowski; Kristina R. Eichhorst; Carlos Encinas Dominguez; Carol A. Haussler; Haussler