Glauciemar Del-Vechio-Vieira
Universidade Federal de Juiz de Fora
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Featured researches published by Glauciemar Del-Vechio-Vieira.
Nutrients | 2014
Érika Maria Henriques Monteiro; Lucas Apolinário Chibli; Célia Hitomi Yamamoto; Mônica Cecília Santana Pereira; Fernanda Maria Pinto Vilela; Mirian Pereira Rodarte; Miriam Aparecida de Oliveira Pinto; Maria da Penha Henriques do Amaral; Marcelo Silva Silvério; Ana Lúcia dos Santos de Matos Araújo; Aílson da Luz André de Araújo; Glauciemar Del-Vechio-Vieira; Orlando Vieira de Sousa
Sesame oil is widely consumed as nutritious food, cooking oil, and in pharmaceuticals and food. In this study, the antinociceptive and anti-inflammatory properties of the sesame oil and sesamin were investigated. The sesame oil and sesamin reduced the number of abdominal contortions at the doses 100, 200, or 400 mg/kg. The first and second phases of the time paw licking were inhibited by sesame oil and sesamin (100, 200, or 400 mg/kg). After 90 min of treatment, sesame oil and sesamin increased the reaction time on a hot plate (200 or 400 mg/kg). Considering the tail-immersion assay, the sesame oil and sesamin produced significant effect after 60 min at the doses of 100, 200, or 400 mg/kg. After 4 h of application of the carrageenan, the sesame oil and sesamin were effective against the paw edema. The exudate volume and leucocyte migration were also reduced by sesame oil and sesamin. These results suggest that sesamin is one of the active compounds found in sesame oil and justify the antinociceptive and anti-inflammatory properties of this product.
Journal of Pharmacy and Pharmacology | 2008
Orlando Vieira de Sousa; Marcelo Silva Silvério; Glauciemar Del-Vechio-Vieira; Filipe C. Matheus; Célia Hitomi Yamamoto; Maria Silvana Alves
The chemical composition of the essential oil from air‐dried leaves of Eremanthus erythropappus was studied. The main compounds were β‐pinene (23.24%), β‐caryophyllene (22.92%), β‐myrcene (10.03%) and germacrene D (9.40%). The essential oil had an LD50 of 2.90 gkg−1 in mice. Doses of 200 and 400 mgkg−1 inhibited 10.69% and 27.06% of acetic‐acid‐induced writhing in mice, respectively. In the formalin‐induced nociception test in mice, the essential oil inhibited the first phase of paw licking by 29.13% (400 mgkg−1) and the second phase by 32.74% (200 mgkg−1) and 37.55% (400 mgkg−1). In the hot‐plate test in mice, doses of 200 mgkg−1 and 400 mgkg−1 significantly increased the reaction time after 30, 60 and 90 min of treatment. Doses of 200 and 400 mgkg−1 inhibited carrageenan‐induced paw oedema in rats by 15.18% and 36.61%, respectively. Doses of 200 and 400 mgkg−1 administered 4 h before intra‐pleural injection of carrageenan significantly reduced exudate volume (by 20.20% and 48.70%, respectively) and leucocyte mobilization (by 5.88% and 17.29%, respectively). These results demonstrate that E. erythropappus has analgesic and anti‐inflammatory properties, supporting the use of this plant in folk medicine.
Molecules | 2013
Marcelo Silva Silvério; Glauciemar Del-Vechio-Vieira; Miriam Aparecida de Oliveira Pinto; Maria José Alves; Orlando Vieira de Sousa
The chemical composition of the essential oils obtained by hydrodistillation of different parts of Eremanthus erythropappus, including leaves, branches and inflorescences, was investigated by Gas Chromatography and Gas Chromatography/Mass Spectrometry. The antimicrobial activity of the oils was assessed by the disc diffusion and microdilution methods, while the antioxidant activity was evaluated by DPPH and reducing power tests. The main compounds found in the essential oils derived from the inflorescences and leaves were β-caryophyllene, germacrene-D, α-copaene and β-pinene. α-Bisabolol was the major component in the branches. The oils were active against Staphylococcus aureus, Streptococcus pyogenes and fungi, but not Escherichia coli and Pseudomonas aeruginosa. The MIC values ranged from 0.01 to 0.50 mg/mL. Using the DPPH test, the IC50 values ranged from 38.77 ± 0.76 to 102.24 ± 1.96 μg/mL, while the reducing power test produced IC50 values between 109.85 ± 1.68 and 169.53 ± 0.64 μg/mL. The results revealed that the E. erythropappus oils are new promising potential sources of antimicrobial and antioxidant compounds with good future practical applications for human health.
Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy | 2008
Marcelo Silva Silvério; Orlando Vieira de Sousa; Glauciemar Del-Vechio-Vieira; Mariza Abreu Miranda; Filipe C. Matheus; Maria Auxiliadora Coelho Kaplan
The present work investigated the antinociceptive, anti-inflammatory and antiulcerogenic activities of Eremanthus erythropappus ethanol extract. The tests were carried out by acetic acid writhing, paw licking induced by formalin, hot plate, indomethacin- and ethanol-induced ulcer. The doses of 50, 100 and 200 mg/kg inhibited the contortions in 43.07, 69.34 and 70.07%, respectively. Both phases of paw lick were reduced at the tested doses, while reaction time at hot plate had significant effect at 200 mg/kg. The paw edema was decreased in 23.81% (100 mg/kg) and 47.62% (200 mg/kg). The index of ulceration induced by indomethacin was reduced at the doses of 100 and 200 mg/kg, while 200 mg/kg decreased the gastric volume and pH. The index of ulceration and gastric volume induced by ethanol was reduced at 200 mg/kg, while the pH increased at 100 and 200 mg/kg. The results indicate that the ethanol extract from E. erythropappus may constitute a potential target for the use in therapies of the pain, inflammation and ulcer.
Oxidative Medicine and Cellular Longevity | 2013
Jucélia Barbosa da Silva; Vanessa dos Santos Temponi; Carolina Miranda Gasparetto; Rodrigo L. Fabri; Danielle Maria de Oliveira Aragão; Nícolas de Castro Campos Pinto; Antônia Ribeiro; Elita Scio; Glauciemar Del-Vechio-Vieira; Orlando Vieira de Sousa; Maria Silvana Alves
The present study evaluated the antioxidant potential of Vernonia condensata Baker (Asteraceae). Dried and powdered leaves were exhaustively extracted with ethanol by static maceration followed by partition to obtain the hexane, dichloromethane, ethyl acetate, and butanol fractions. Total phenols and flavonoids contents were determined through spectrophotometry and flavonoids were identified by HPLC-DAD system. The antioxidant activity was assessed by DPPH radical scavenging activity, TLC-bioautography, reducing power of Fe+3, phosphomolybdenum, and TBA assays. The total phenolic content and total flavonoids ranged from 0.19 to 23.11 g/100 g and from 0.13 to 4.10 g/100 g, respectively. The flavonoids apigenin and luteolin were identified in the ethyl acetate fraction. The IC50 of DPPH assay varied from 4.28 to 75.10 µg/mL and TLC-bioautography detected the antioxidant compounds. The reducing power of Fe+3 was 19.98 to 336.48 μg/mL, while the reaction with phosphomolybdenum ranged from 13.54% to 32.63% and 56.02% to 135.00% considering ascorbic acid and rutin as reference, respectively. At 30 mg/mL, the ethanolic extract and fractions revealed significant effect against lipid peroxidation. All these data sustain that V. condensata is an important and promising source of bioactive substances with antioxidant activity.
Brazilian Archives of Biology and Technology | 2009
Glauciemar Del-Vechio-Vieira; Orlando Vieira de Sousa; Mariza Abreu Miranda; Luci Senna-Valle; Maria Auxiliadora Coelho Kaplan
The chemical composition, analgesic and anti-inflammatory properties of essential oil from Ageratum fastigiatum were investigated. The main compounds found in the essential oil were germacrene D, α-humulene and β-cedrene. The oil, with LD50 of 2.50 g/kg, inhibited the acetic acid-induced writhing at the dose of 200 mg/kg. In the formalin test, the oil inhibited the first phase (200 mg/kg) and the second phase (100 mg/kg and 200 mg/kg). In the hot plate test, after 30 and 60 min of treatment the doses of 100 and 200 mg/kg increased the reaction time. The antiedematogenic effect, reduction on the exudate volume and leukocyte mobilization were observed at the doses of 100 and 200 mg/kg. The results indicated that A. fastigiatum possessed the analgesic and anti-inflammatory properties that supported the popular medicinal use of the plant.
Molecules | 2012
Orlando Vieira de Sousa; Glauciemar Del-Vechio-Vieira; Maria Silvana Alves; Aílson A. L. Araújo; Miriam Aparecida de Oliveira Pinto; Maria da Penha Henriques do Amaral; Mirian Pereira Rodarte; Maria Auxiliadora Coelho Kaplan
Essential oils of Duguetia lanceolata barks, obtained at 2 (T2) and 4 h (T4), were identified by gas chromatography and gas chromatography/mass spectrometry. β-Elemene (12.7 and 14.9%), caryophyllene oxide (12.4 and 10.7%) and β-selinene (8.4 and 10.4%) were the most abundant components in T2 and T4, respectively. The essential oils inhibited the growth of Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Candida albicans. The essential oils were cytotoxic against brine shrimp. The extraction time influenced the chemical composition and biological activities of essential oils obtained from the barks of D. lanceolata.
International Journal of Molecular Sciences | 2012
Vanessa dos Santos Temponi; Jucélia Barbosa da Silva; Maria Silvana Alves; Antônia Ribeiro; José de Jesus Ribeiro Gomes de Pinho; Célia Hitomi Yamamoto; Miriam Aparecida de Oliveira Pinto; Glauciemar Del-Vechio-Vieira; Orlando Vieira de Sousa
The ethanol extract from Vernonia polyanthes leaves (EEVP) was investigated for antinociceptive and anti-inflammatory effects at the doses (p.o.) of 100, 200 and 400 mg/kg in animal models. The extract reduced the number of abdominal contortions by 16.75% and 31.44% at a dose of 200 and 400 mg/kg, respectively. The results obtained showed that EEVP exerted a significant antinociceptive effect in the two phases of formalin. The EEVP increased the reaction time on a hot plate at the doses of 100, 200 and 400 mg/kg after 90 min of treatment. The paw edema was reduced by EEVP at the doses of 100, 200 and 400 mg/kg after 4 h of application of carrageenan. Doses of 200 and 400 mg/kg, administered 4 h before the carrageenan injection, significantly reduced the exudate volume (29.25 and 45.74%, respectively) and leukocyte migration (18.19 and 27.95%, respectively). These results suggest that V. polyanthes can be an active source of substances with antinociceptive and anti-inflammatory activities.
International Journal of Molecular Sciences | 2016
Kamilla Rodrigues; Lucas Apolinário Chibli; Bruna Celeida Silva Santos; Vanessa dos Santos Temponi; Nícolas de Castro Campos Pinto; Elita Scio; Glauciemar Del-Vechio-Vieira; Maria José Alves; Orlando Vieira de Sousa
Vernonia polyanthes Less. (Asteraceae), popularly known as “assa-peixe”, is a plant species used in Brazilian traditional medicine for the treatment of cutaneous damage, cicatrization, inflammation, and rheumatism. Based on these ethnopharmacological findings, the current study evaluated the topical anti-inflammatory effects of the hexane (HEVP) and ethyl acetate (EAEVP) extracts from V. polyanthes leaves in experimental models of skin inflammation. Chemical characterization was carried out by HPLC–UV/DAD analysis. Anti-inflammatory activity was evaluated using Croton oil-, arachidonic acid (AA)-, phenol-, ethyl phenylpropiolate (EPP)-, and capsaicin-induced ear edema models in mice. Histopathological evaluation and measurements of myeloperoxidase (MPO) and N-acetyl-β-d-glucosaminidase (NAG) enzymes were also performed. Rutin, luteolin, and apigenin were identified in EAEVP. Topically applied HEVP and EAEVP significantly (p < 0.05, p < 0.01 or p < 0.001) reduced edema induced by five different irritants at the doses tested (0.1, 0.5 and 1.0 mg/ear). Histopathological analysis revealed a reduction of edema, inflammatory cell infiltration, and vasodilation. In addition, the enzymes activity (MPO and NAG) in the ear tissues was reduced by the topical treatment of HEVP and EAEVP (p < 0.05, p < 0.01 or p < 0.001). The results suggest that V. polyanthes leaves are effective against cutaneous damage, which support its traditional use and open up new possibilities for the treatment of skin disorders.
African Journal of Pharmacy and Pharmacology | 2012
Orlando Vieira de Sousa; Glauciemar Del-Vechio-Vieira; Maria Silvana Alves; Jesus Ribeiro; Gomes de Pinho; Célia Hitomi Yamamoto; Maria Auxiliadora Coelho
In the current investigation, the antinociceptive and anti-inflammatory effects of the ethyl acetate and butanol fractions from Annona coriacea leaves were evaluated using standard experimental test models. The antinociceptive activity of A. coriacea was studied by acetic acid-induced writhing, formalin and hot-plate tests, and the anti-inflammatory activity was determined by carrageenan-induced rat paw edema and carrageenan-induced pleurisy. Inhibition of the acetic acid-induced abdominal contortions was observed at the doses of 50 and 100 mg/kg. After injection of formalin, the dose of 100 mg/kg inhibited the time spent paw licking in the first phase, while the second phase was inhibited at the doses of 10, 50 or 100 mg/kg. In the hot-plate assay, the reaction time was increased at 90 min in animals that received 100 mg/kg. Doses of 50 and 100 mg/kg inhibited carrageenan-induced paw edema, the exudate volume, and leucocyte migration. The present results demonstrate that fractions of A. coriacea have antinociceptive and anti-inflammatory effects, supporting the use of this plant in folk medicine.
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Miriam Aparecida de Oliveira Pinto
Universidade Federal de Juiz de Fora
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