Gloria Ríos

Celiac disease in a Chilean population carrying Amerindian traits.

Background Although clinical manifestations of celiac disease may change throughout life, clinical, histologic, immunologic, and genetic studies show that there are incomplete forms of this condition, making it difficult to define the disease at a given moment. Because there is no information published in the Latin American-Amerindian population, this study was conducted to assess relations between these parameters in Chileans with celiac disease and their first-degree relatives. Methods Sixty-two persons with confirmed celiac disease (mean age, 17.9 ± 5.1 years; 78.3% females) and 126 relatives (mean age, 27.9 ± 17.2 years; 65.1% females) were evaluated. Clinical manifestations, antiendomysial antibodies (EMAs), and human leukocyte antigen (HLA) haplotypes were studied in patients. Additionally, jejunal biopsy specimens were assessed (light microscopy) in EMA-positive (EMA+) relatives. Results Of the patients, 24.1% adhered to a strict gluten-free diet; 26% were oligosymptomatic, and none were malnourished; 45% were EMA+; 13.8% who ingested gluten were EMA-negative (EMA−); one patient consuming a strict gluten-free diet was EMA+. The DQA1*0501 allele was present in the highest frequency (48%, P < 0.0005), whereas combinations of DQ8 were predominant. Of the relatives, 4.8% were EMA+; they had a significantly higher frequency of diarrhea, weight loss, and anorexia (P < 0.03); and all had abnormal histology in biopsy specimens. Conclusions After childhood, celiac disease is oligosymptomatic and is often unrecognized by patients. Disease in 13.8% of patients and in 4.8% relatives appeared as incomplete forms of celiac disease. Predominance of DQ8 HLA haplotypes reflects the genetic Spanish-Mapuche heritage of this population.

Effect of calcium and vitamin D supplementation on bone mineral density of celiac children

Abstract We were interested in detecting the changes in bone mineral density (BMD) in prepuberal and puberal celiac children after 24 months of supplementation with 1000 mg of calcium and 400 U of vitamin D daily. 19 celiac children (16 females, and 3 males, age 6 to 15 years) with good compliance to the gluten free diet for at least two years, paired with 19 healthly children of the same age and sex were studied. Celiac patients had mean calcium intakes of 739 mg per day, that increased to 1444 mg per day after nutritional supplementation, with 84 and 74% of compliance during the first and second years of supplementation. Celiac patients did not show significant changes in stature and nutritional status during supplementation. The whole group of celiac subjects showed a significant increase in z score of WB-BMD and FN-BMD from the start and until 24 months of supplementation, compared to the controls (WB-BMD: −0.24±0.40 and −0.80±0.59 vs 0.49±0.62 and 0.62±0.83. FN-BMD:−0.41±0.96 and 0.04±1.12 vs 0.58±1.29 and 0.36±1.15 respectively) Total group and pubertal celiac patients showed a significantly greater variation (delta z score) of hip BMD (FN-BMD 0.53 ± 0.85 p

BONE MINERAL DENSITY (BMD) IN CHILDREN WITH CELIAC DISEASE (CD): ITS RELATION TO PUBERTY AND CALCIUM INTAKE

Abstract Bone mineral density (BMD) and calcium intake were studied in 39 celiac patients (CP) with good compliance for the gluten free diet in 39 healthy subjects, aged 6 to 16 years of age (17 prepuberal and 22 puberal) in a case-control design (1;1). Nutritional and statural adequacy were evaluated by means of the body mass index (BMI), and height for age (H/A) respectively, expressed as z score. BMD in the whole body, spine and hip was evaluated using a LUNAR densitometer in prepuberal and as puberal CD. Food intake was determined by 24 hours recall. Antiendomisium and anti-gliadin antibodies and bone age were also evaluated. Statural adequacy of celiacs was significantly lower (p

Niveles plasmáticos de vitamina D e ingesta de calcio en niños celiacos: factores de riesgo para su salud futura

Objetivo: Evaluar los niveles plasmaticos de vitamina D y la ingesta de calcio en pacientes celiacos. Material y Metodo: 25 pacientes celiacos (20 mujeres y 5 hombres, de 5 a 15 anos de edad) con una buena adhesion al regimen libre de gluten de al menos los dos ultimos anos. La ingesta de calcio se evaluo mediante tres encuestas de recordatorio de 24 horas. La 25 OH vitamina D se determino mediante RIA (INCSTAR). Resultados: Un 80% de los pacientes presento una ingesta de calcio insuficiente de acuerdo al consenso del NIH; en los menores de 10 anos la ingesta promedio fue de 866 ( 423 y en los mayores de 11 anos 605 ( 237 mg/dia. Se encontro deficit de vitamina D (<37.5 nmol/L o 15 ng/mL) en 5 de los casos (20%), de los cuales 4 corresponden a muestras tomadas en invierno y una en verano. En dos casos el deficit fue severo <20 nmoles/L (<8 ng/ml). Conclusion: En pacientes celiacos evaluados la hipovitaminosis D y la ingesta insuficiente de calcio fueron situaciones frecuentes, lo que puede producir el deficit de masa osea detectado en estos pacientes y facilitar el desarrollo futuro de osteoporosis y diabetes. Se recomienda evaluar los niveles de vitamina D y la ingesta de calcio como parte del control de estos pacientes y en caso necesario efectuar una suplementacion con calcio y vitamina D

Effect of A 24 Months Calcium and Vitamin D Supplementation on Bone Mineralization in Coeliac Patients (CP)

Effect of A 24 Months Calcium and Vitamin D Supplementation on Bone Mineralization in Coeliac Patients (CP)

Growth and Bone Mineralization in Children With Cellac Disease (Cd). Effect of Calcium and Vitamin D Supplementation 10

Growth and Bone Mineralization in Children With Cellac Disease (Cd). Effect of Calcium and Vitamin D Supplementation 10

Efect of Calcium and Vitamin D Suplementation on Bone Mineralization (Bm) of Children With Coeliac Disease (Cd)

Efect of Calcium and Vitamin D Suplementation on Bone Mineralization (Bm) of Children With Coeliac Disease (Cd)

Bone Mineralization in Celiac Disease (Cd) in Children

An alteration of 25 OH Vit D metabolism and of enteric proteins participating in calcium transport, decrease calcium intestinal absorption and bone mineralization, in CD Growth and bone mineralization of 36 celiac children of both sexes, aged 6 to 16 years and with as an average of 5 years of satifactory compliance with the gluten fee diet were evaluated through a paired case, control study. Nutritional and growth status were studied through weight/height, body fat and height/age measurements, according to WHO charts. Dietary compliance was verified by determination of antigliadin and antiendomisium antibodies. Bone mineral density (BMD) was measured in the spine, hip and total body with a Lunar radiologic densitometer and results were expressed as Z score, using reference from healthy spanish children population. For statistical analysis student T test and relative risk were calculated. A significant lower statural adequation was obsserved in CD(96.6±5.5) compared with the controls (101.5±5.4) while no differences in ponderal adequation and body fat were detected. CD patients had significant lower BMD in total body, spine and femoral neck(-0.19±0.63.-0.92±0.98 and -0.3±0.99 respectivelly) than controls (0.47±0.64, 0.23±1.37 and 0.29-±1.09 respectivelly. CD patients were at increased risk of a bone mineralization below -1 s.d. in total body and spine (2.13 and 1.96 times respectivelly) than controls. These results indicate that children with CD are at high risk of developing osteoporosis in the adult life.