Gm Hassett

Radiographic Progression of Lumbar Spine Disc Degeneration Is Influenced by Variation at Inflammatory Genes : A Candidate SNP Association Study in the Chingford Cohort

Study Design. A candidate gene association study in a longitudinal cohort. Objective. To investigate the association between polymorphisms at 25 candidate genes and progression of individual radiographic features of lumbar disc degeneration (LDD). Summary of Background Data. LDD is characterized radiographically by the presence of osteophytes and disc space narrowing and is known to have a genetic component. Because of the high prevalence of radiographic features, progression may be a more useful phenotype clinically to study than prevalence itself. Methods. We tested the effect on radiographic progression of LDD of polymorphisms in 25 genes, 24 of which had been previously tested with regards to knee osteoarthritis. The progression traits used were the change in radiographic grade over 9 years in osteophytes, disc space narrowing, and summary Kellgren-Lawrence grade. Lumbar spine radiographs (L1–L5) at baseline and at follow-up were read for 720 women genotyped at the 25 genes participating in the Chingford study. Results. Polymorphisms in MMP3, TIMP1, and COX2, which encode molecules involved in inflammatory pathways, were associated with radiographic progression of LDD. The strongest associations observed (statistically significant after correcting for multiple comparisons) were between COX2 and change in osteophyte grade (P < 0.001) and Kellgren-Lawrence grade (P < 2 × 10−5), and between the genes for vitamin D receptor (P < 0.002) and a thrombospondin (THSD2) (P < 0.002) and change in osteophyte grade. Conclusions. Our results suggest a role for genes regulating inflammatory pathways in the radiographic progression of spine degeneration. This could prove a fruitful area for future therapeutics for the spine and other joints.

Acute gout management during hospitalization: a need for a protocol

Aim: To review systematically the management of acute gout during hospitalization.

Improved management of acute gout during hospitalization following introduction of a protocol

Aim:  To determine whether implementation of a protocol to manage in‐hospital acute gout has improved the care of patients by non‐rheumatologists.

Long-term outcomes of vertebroplasty for osteoporotic compression fractures.

Introduction: This study aimed to determine outcomes of percutaneous vertebroplasty for osteoporotic vertebral compression fractures (VCFs).

ORIGINAL ARTICLE: Long-term outcomes of vertebroplasty for osteoporotic compression fractures

Introduction: This study aimed to determine outcomes of percutaneous vertebroplasty for osteoporotic vertebral compression fractures (VCFs).

ORIGINAL ARTICLE: Long-term outcomes of vertebroplasty for osteoporotic compression fractures: Outcomes of vertebroplasty

Introduction: This study aimed to determine outcomes of percutaneous vertebroplasty for osteoporotic vertebral compression fractures (VCFs).