Gompachi Yajima

A HISTOPATHOLOGICAL STUDY ON DIABETIC NEPHROPATHY — LIGHT AND ELECTRON MICROSCOPIC OBSERVATIONS

A historical review and the present authors study on diabetic nephropathy have been presented.

IMMUNE COMPLEX‐MEDIATED GLOMERULONEPHRITIS AND INTERSTITIAL PNEUMONIA SIMULATING GOODPASTURE'S SYNDROME

An autopsy case of what was clinically considered to be Goodpastures syndrome was Investigated. The lung had hemorrhagic interstitial pneumonia, showing granular patterns of IgG and C3 along the alveoli by the immunofluo‐rescent method and electron‐dense subepithelial deposits by electron microscopy. The kidney had crescentic and segmental necrotizing glomerulonephritis associated with membranous nephropathy. Uneven, continuous patterns of immunofluorescent IgG and C3 along the GBM were noted. Electron microscopy showed numerous subepithelial deposits, and immunoelectron microscopy revealed that IgG was not present in the GBM itself but present in the subepithelial deposits. Anti‐GBM antibody activity was not detected in the serum or the kidney eluate. It was suggested that renal and pulmonary lesions occurred through the same mechanism and in association with immune deposits. We propose that there is a disease having immune complex‐mediated renal and pulmonary lesions which clinically resembles the conventional Goodpastures syndrome.

AN ADULT CASE OF PRIMARY PULMONARY HYPERTENSION; AS COMPARED WITH AN ADULT CASE OF PATENT DUCTUS BOTALLI AND EXPERIMENTAL VASOPRESSIN PULMONARY THROMBOARTERIOPATHY OF THE RABBIT

According to SPENCER, the first case of a “ primary arterial disorder confined to the lung” had been repoIted by MONCKEBERG in 1907. Since then, reported cases of “ primary pulmonary hypertension ” as well as “ secondary ” due to a fore-going cardiovascular anomaly have increased in number. Although the peculiar arterial changes called as the “ plexiform ”, “angiomatoid”, “ glomoid ” or “ glomerulus-like ” structures or the “ arteriovenous shunts ”, etc, have been reported by several authors, the essential changes of the pulmonary arteries in these disorders are now believed to be thrombosclerotic in nature. On the other hand, DUGUID’S fascinating thrombosclerotic concept on coronary sclerosis have been followed by many experimental studies on arterial thrombosclerosis of the lung. Recently, we have had a chance to study almost simultaneously a case of this disorder and a case of “ secondary pulmonary hypertension ”, each of which was a woman of 38 years. Furthermore, YAJIMA observed experimental systemic pulmonary thrombosis of the rabbit induced by YANO with Vasopressin. This report is the result of observations on thrombosclerotic lesions of the lnug found in these materials.