GÖran Molin
Malmö University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by GÖran Molin.
Surgery | 2003
Henrik Thorlacius; Sören Nobaek; Xian Dong Wang; Roland Andersson; GÖran Molin; Stig Bengmark; Bengt Jeppsson
BACKGROUND Systemic administration of antibiotics or selective decontamination is frequently used in the prophylaxis and treatment of infections originating from the gastrointestinal flora. In this study, we wanted to compare the protective effect of enteral administration of lactobacilli to gentamicin against severe intra-abdominal infection. METHODS Male Sprague-Dawley rats underwent cecal ligation and puncture (CLP). Rats were pretreated with saline, Lactobacillus R2LC, and gentamicin. Bacterial growth and endotoxin levels in the blood, reticuloendothelial system (RES)-function, and intestinal transit were determined up to 24 hours after CLP. RESULTS CLP-provoked bacteremia was significantly reduced by 48% and 55% in lactobacilli- and gentamicin-treated rats, respectively. Notably, CLP-induced endotoxemia was abolished at 12 hours, and reduced by 47% at 24 hours, in rats pretreated with lactobacilli. Gentamicin reduced endotoxin levels provoked by CLP by 86% at 12 hours, but had no effect at 24 hours. Lactobacilli had no effect on the clearance of Escherichia coli (E coli) from the blood, whereas intestinal transit was increased in lactobacilli-treated animals, suggesting that the beneficial effect of Lactobacillus R2LC is not related to an increase of phagocytic capacity but may rather be partly attributable to an enhanced intestinal motility. CONCLUSION Enteral administration of Lactobacillus R2LC attenuates bacteremia and endotoxemia associated with intra-abdominal infection in rats.
Archive | 1992
GÖran Molin; Siv Ahrné; Stig Bengmark; Bengt Jeppson
Archive | 1996
Ingegerd Adlerberth; Siv Ahrné; Bengt Jeppsson; Marie-Louise Johansson; GÖran Molin; Agnes E. Wold
Archive | 1992
Stig Bengmark; Siv Ahrné; GÖran Molin; Bengt Jeppson
Archive | 1996
Diya Adawi; Bengt Jeppson; GÖran Molin
Archive | 2003
Ingegerd Adlerberth; Siv Ahrné; Bengt Jeppsson; Marie-Louise Johansson; GÖran Molin; Agnes E. Wold
Archive | 2017
Jörg Thilo Fischer; Marcus Rudolf Götz; GÖran Molin; Siv Ahrné
Archive | 2016
Beatrix Alsanius; Sofia Windstam; Rahel Hartmann; Siv Ahrné; GÖran Molin
Archive | 2005
GÖran Molin; Siv Ahrné; Bengt Jeppsson; Alejandra Vásquez; Anna Berggren
Archive | 2004
GÖran Molin; Siv Ahrné; Bengt Jeppsson