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Featured researches published by GÖran Molin.


Surgery | 2003

Lactobacilli attenuate bacteremia and endotoxemia associated with severe intra-abdominal infection

Henrik Thorlacius; Sören Nobaek; Xian Dong Wang; Roland Andersson; GÖran Molin; Stig Bengmark; Bengt Jeppsson

BACKGROUND Systemic administration of antibiotics or selective decontamination is frequently used in the prophylaxis and treatment of infections originating from the gastrointestinal flora. In this study, we wanted to compare the protective effect of enteral administration of lactobacilli to gentamicin against severe intra-abdominal infection. METHODS Male Sprague-Dawley rats underwent cecal ligation and puncture (CLP). Rats were pretreated with saline, Lactobacillus R2LC, and gentamicin. Bacterial growth and endotoxin levels in the blood, reticuloendothelial system (RES)-function, and intestinal transit were determined up to 24 hours after CLP. RESULTS CLP-provoked bacteremia was significantly reduced by 48% and 55% in lactobacilli- and gentamicin-treated rats, respectively. Notably, CLP-induced endotoxemia was abolished at 12 hours, and reduced by 47% at 24 hours, in rats pretreated with lactobacilli. Gentamicin reduced endotoxin levels provoked by CLP by 86% at 12 hours, but had no effect at 24 hours. Lactobacilli had no effect on the clearance of Escherichia coli (E coli) from the blood, whereas intestinal transit was increased in lactobacilli-treated animals, suggesting that the beneficial effect of Lactobacillus R2LC is not related to an increase of phagocytic capacity but may rather be partly attributable to an enhanced intestinal motility. CONCLUSION Enteral administration of Lactobacillus R2LC attenuates bacteremia and endotoxemia associated with intra-abdominal infection in rats.


Archive | 1992

Intestine colonizing lactobacilli

GÖran Molin; Siv Ahrné; Stig Bengmark; Bengt Jeppson


Archive | 1996

Epithelial adhesive lactobacilli

Ingegerd Adlerberth; Siv Ahrné; Bengt Jeppsson; Marie-Louise Johansson; GÖran Molin; Agnes E. Wold


Archive | 1992

Intestine colonizing strains of lactobacilli

Stig Bengmark; Siv Ahrné; GÖran Molin; Bengt Jeppson


Archive | 1996

Pharmaceutical composition comprising lactobacillus plantarum and arginine

Diya Adawi; Bengt Jeppson; GÖran Molin


Archive | 2003

USE OF EPITHELIAL ADHESIVE LACTOBACILLI

Ingegerd Adlerberth; Siv Ahrné; Bengt Jeppsson; Marie-Louise Johansson; GÖran Molin; Agnes E. Wold


Archive | 2017

Novel probiotic bacterial strain of lactobacillus plantarum and compositions and uses thereof in the treatment of inflammation

Jörg Thilo Fischer; Marcus Rudolf Götz; GÖran Molin; Siv Ahrné


Archive | 2016

E. coli:s dolda liv

Beatrix Alsanius; Sofia Windstam; Rahel Hartmann; Siv Ahrné; GÖran Molin


Archive | 2005

Souches de lactobacillus probiotiques pour une hygiene vaginale amelioree

GÖran Molin; Siv Ahrné; Bengt Jeppsson; Alejandra Vásquez; Anna Berggren


Archive | 2004

Compositions comprenant des souches de lactobacillus plantarum combinees a du tanin et nouvelles souches de lactobacillus plantarum

GÖran Molin; Siv Ahrné; Bengt Jeppsson

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Agnes E. Wold

University of Gothenburg

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Bertil Pettersson

Royal Institute of Technology

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