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Gordon Alan Hughes

Bryn Mawr College

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Featured researches published by Gordon Alan Hughes.

Steroids | 1963

Biological effects of racemic and resolved 13β-ethyl-4-gonen-3-ones

Richard A. Edgren; Herchel Smith; Gordon Alan Hughes; Leland L. Smith; George Greenspan

Abstract Various biological effects of (±)-13β-ethyl-17β-hydroxygon-4-en-3-one, (±)-13β-ethyl-17α-ethynyl-17β-hydroxygon-4-en-3-one, and (±)-13β, 17α-diethyl-17β-hydroxygon-4-en-3-one were compared with resolved samples of the component enantiomers. The data were commensurate with the hypothesis that biological activity resides in the enantiomers possessing absolute configurations corresponding to those of the natural steroid hormones.

Steroids | 1966

Totally synthetic steroid hormones. Part XIV. (±)-18-methyl-19-norprogesterone, 18-methyl-19-nordesoxycorticosterone and related compounds

Gordon Alan Hughes; Timothy Y. Jen; Herchel Smith

Abstract An account is given of the total synthesis of (±)-18-methyl-19-norprogesterone III, its 17α-epimer IIIa, (±)-18-methyl-19-nordesoxycorticosterone XIIa, its acetate XII, (±)-21-hemisuccinoyloxy-18-methyl-19-nor-5β-pregnan-3-one XIXb, and various cognate compounds. Also reported are the progestational activities of III and IIIa, the mineralocortiod activities of XII and XIIa, and some central nervous system effects of the sodium salt of XIXb.

Journal of The Chemical Society (resumed) | 1963

975. Totally synthetic steroid hormones. Part I. Oestrone and related œstrapolyenes

George H. Douglas; J. M. H. Graves; David Hartley; Gordon Alan Hughes; B.J. McLoughlin; J. Siddall; Herchel Smith

Journal of The Chemical Society (resumed) | 1964

856. Totally synthetic steroid hormones. Part II. 13β-Alkylgona-1,3,5(10)-trienes, 13β-alkygon-4-en-3-ones, and related compounds

Hercherl Smith; Gordon Alan Hughes; G. H. Douglas; G. R. Wendt; G. C. Buzby; Richard A. Edgren; James F. Fisher; Theodore J. Foell; B. Gadsby; D. Hartley; D. Herbst; A. B. A. Jansen; K. Ledig; B. J. McLoughlin; J. McMenamin; T. W. Pattison; P. C. Phillips; Richard W. Rees; J. Siddall; J. Siuda; Leland L. Smith; J. Tokolics; D. H. P. Watson

Recent Progress in Hormone Research | 1966

Biological Effects of Synthetic Gonanes

Richard A. Edgren; DeAnn L. Peterson; Robert C. Jones; Clarence L. Nagra; Herchel Smith; Gordon Alan Hughes

Archive | 1964

Synthesis of 13-alkyl-gon-4-ones

Gordon Alan Hughes; Herchel Smith

Journal of Medicinal Chemistry | 1967

Totally synthetic steroid hormones. 13. The chemical resolution of some racemic estrane, 13-beta-ethylgonane, and 13-beta-n-propylgonane derivatives and the preparation of some estrane and 13-beta-ethylgonane derivatives of unnatural configuration.

George C. Buzby Jr.; David Hartley; Gordon Alan Hughes; Herchel Smith; B. W. Gadsby; A. B. A. Jansen

Journal of Medicinal Chemistry | 1966

Totally synthetic steroid hormones. VII. Some (+ or-)-8-alpha-estrane and (+ or -)-13-beta-alkyl-8-alpha-gonane derivatives.

Buzby Gc; Capaldi E; Douglas Gh; Hartley D; Herbst D; Gordon Alan Hughes; Ledig K; McMenamin J; Pattison T; Herchel Smith; Walk Cr; Wendt Gr; Siddall J; Gadsby B; Jansen Ab

Archive | 1966

N-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES

Joseph Tokolics; Gordon Alan Hughes; Herchel Smith

Archive | 1967

Preparation of 13-alkylgona-1, 3, 5 (10), 8, 14-pentaenes

Gordon Alan Hughes; Herchel Smith

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Herchel Smith

Bryn Mawr College

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Leland L. Smith

University of Texas Medical Branch

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Theodore J. Foell

American Cyanamid

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