Goro Urakubo

Metabolic fate of 2,5-dimethoxy-4-methylamphetamine in the guinea pig and rabbit.

Metabolic fate of 2, 5-dimethoxy-4-methylamphetamine (DOM) was investigated in the guinea pig and rabbit. DOM concentration in serum decreased rapidly after a subcutaneous injection and DOM was scarcely obtained at 3 to 4 hours later by radioimmunoassay and thin-layer chromatography. As the metabolites of DOM, 2, 5-dimethoxy-4-hydroxymethylphenyl-2-aminopropane and 2, 5-dimethoxy-4-carboxyphenyl-2-aminopropane were confirmed in the urine of guinea pig and rabbit. 2, 5-Dimethoxy-4-methylphenyl-2-propanol and 2, 5-dimethoxy-4-methylphenyl-2-propanone, which had not been detected in rat urine but in the incubation mixture of DOM with rabbit liver microsome, were identified in guinea pig and rabbit urines. 2, 5-Dimethoxy-4-methylbenzoic acid was firstly detected as a minor metabolic product of DOM in the urine of both species of animals. Principal metabolic pathway of DOM in guinea pig was not regarded as the side-chain oxidation but as the oxidation of methyl group on benzene ring as well as in rabbit.

Studies on the Quality and Test Method of Radiopharmaceuticals (2)

6種類の放射性医薬品についてペーパークロマトグラフィまたはロ紙電気泳動による純度試験に適した展開溶媒および泳動条件を検討した結果, 注射用放射性塩化第二鉄液はアセトン-塩酸-水=4: 1: 3, 放射性クロム酸ナトリウム注射液はn-ブタノールーメタノール-水-ベンゼン=10: 20: 50: 1, 放射性シアノコバラミン液はn-ブタノールーピリジンーエタノール-6N-塩酸=10: 40: 5: 30, 放射性クロルメロドリン注射液はジメチルホルムアミドーエタノールー水=2: 8: 2, 放射性ヨウ化インシュリン注射液はn-ブタノールー酢酸-水=3: 1: 4の混合溶媒系を用いるペーパークロマトグラフィで好結果を得, さらに放射性ヨウ化インシュリン注射液の場合は20%ギ酸を電解液とするロ紙電気泳動においても, また放射性ヨウ化人血清アルブミン注射液はベロナール緩衝液を用いて, それぞれ満足すべき結果を得た。

Investigation on Some Domestic Wares Containing Natural Radioactive Substance

Investigation was carried out on some kinds of domestic wares containing natural radioactive substance. These articles, namely a pillow, a tile plate, a belt and so on, are produced in a particular factory and are sold in market with special advertisement for keeping health or for utilizing their weak radiation. The radioactive substance contained in these articles was prepared from a kind of ore called Monazite. The γ-spectrum of this sandy ore with Malti-channel Pulse Height Analyzer was quite identical to that of thorium, and the thorium content was 4.7∼23.7 percent by chemical analysis. We found considerable dose of radiation derived from these articles with Lauritzen electroscope as shown in TABLE I. It is very difficult to consider if these articles might be safe for life, because we can not know the actual dose of radiation during use of them. However, roughly speaking, these articles may not be safe for health, if they are used very freely. We are feeling that we should have a scientifically authorized safety limit or alarm level of the radioactivity for use of these domestic wares.