Gph Leung | Researchain

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Featured researches published by Gph Leung.

British Journal of Pharmacology | 2009

Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells

Sai Wang Seto; Als Au; Tsz Yan Lam; Stephen Siu Chung Chim; Simon Ming-Yuen Lee; S Wan; D C S Tjiu; N Shigemura; Anthony P.C. Yim; Shun-Wan Chan; Stephen Kwok-Wing Tsui; Gph Leung; Yiu Wa Kwan

Statins (3‐hydroxy‐3‐methyl‐glutaryl coenzyme A (HMG CoA) reductase inhibitors) have been demonstrated to reduce cardiovascular mortality. It is unclear how the expression level of HMG CoA reductase in cardiovascular tissues compares with that in cells derived from the liver. We hypothesized that this enzyme exists in different cardiovascular tissues, and simvastatin modulates the vascular iberiotoxin‐sensitive Ca2+‐activated K+ (BKCa) channels.

British Journal of Pharmacology | 2008

Kaempferol stimulates large conductance Ca2+‐activated K+ (BKCa) channels in human umbilical vein endothelial cells via a cAMP/PKA‐dependent pathway

Yan Chun Xu; Gph Leung; P. Y. D. Wong; Paul M. Vanhoutte; Ricky Y. K. Man

Kaempferol has been shown to possess a vasodilator effect but its mechanism of action remains unclear. In this study, experiments were carried out to study the effect of kaempferol on K+ channels in endothelial cells.

Archive | 2009

Role of extracellular signal-related kinases in the pathophysiology of vascular dysfunction in aging and hypertension

Sws Leung; Yw Ho; Gsk Man; Gph Leung; Ryk Man

This free access journal suppl. is Proceedings of the 10th International Symposium on Mechanisms of Vasodilatation 2009This free access journal suppl. is Proceedings of the 10th International Symposium on Mechanisms of Vasodilatation 2009This free access journal suppl. is Proceedings of the 10th International Symposium on Mechanisms of Vasodilatation 2009This free access journal suppl. is Proceedings of the 10th International Symposium on Mechanisms of Vasodilatation 2009

Archive | 2009