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Dive into the research topics where Graeme Mackenzie is active.

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Featured researches published by Graeme Mackenzie.


BMJ | 2011

Self correction of refractive error among young people in rural China: results of cross sectional investigation

Mingzhi Zhang; Riping Zhang; Mingguang He; Wanling Liang; Xiaofeng Li; Lingbing She; Yunli Yang; Graeme Mackenzie; J.D. Silver; Leon B. Ellwein; Bruce Moore; Nathan Congdon

Objective To compare outcomes between adjustable spectacles and conventional methods for refraction in young people. Design Cross sectional study. Setting Rural southern China. Participants 648 young people aged 12-18 (mean 14.9 (SD 0.98)), with uncorrected visual acuity ≤6/12 in either eye. Interventions All participants underwent self refraction without cycloplegia (paralysis of near focusing ability with topical eye drops), automated refraction without cycloplegia, and subjective refraction by an ophthalmologist with cycloplegia. Main outcome measures Uncorrected and corrected vision, improvement of vision (lines on a chart), and refractive error. Results Among the participants, 59% (384) were girls, 44% (288) wore spectacles, and 61% (393/648) had 2.00 dioptres or more of myopia in the right eye. All completed self refraction. The proportion with visual acuity ≥6/7.5 in the better eye was 5.2% (95% confidence interval 3.6% to 6.9%) for uncorrected vision, 30.2% (25.7% to 34.8%) for currently worn spectacles, 96.9% (95.5% to 98.3%) for self refraction, 98.4% (97.4% to 99.5%) for automated refraction, and 99.1% (98.3% to 99.9%) for subjective refraction (P=0.033 for self refraction v automated refraction, P=0.001 for self refraction v subjective refraction). Improvements over uncorrected vision in the better eye with self refraction and subjective refraction were within one line on the eye chart in 98% of participants. In logistic regression models, failure to achieve maximum recorded visual acuity of 6/7.5 in right eyes with self refraction was associated with greater absolute value of myopia/hyperopia (P<0.001), greater astigmatism (P=0.001), and not having previously worn spectacles (P=0.002), but not age or sex. Significant inaccuracies in power (≥1.00 dioptre) were less common in right eyes with self refraction than with automated refraction (5% v 11%, P<0.001). Conclusions Though visual acuity was slightly worse with self refraction than automated or subjective refraction, acuity was excellent in nearly all these young people with inadequately corrected refractive error at baseline. Inaccurate power was less common with self refraction than automated refraction. Self refraction could decrease the requirement for scarce trained personnel, expensive devices, and cycloplegia in children’s vision programmes in rural China.


Ophthalmology | 2011

The child self-refraction study results from urban Chinese children in Guangzhou

Mingguang He; Nathan Congdon; Graeme Mackenzie; Yangfa Zeng; J.D. Silver; Leon B. Ellwein

OBJECTIVE To compare visual and refractive outcomes between self-refracting spectacles (Adaptive Eyecare, Ltd, Oxford, UK), noncycloplegic autorefraction, and cycloplegic subjective refraction. DESIGN Cross-sectional study. PARTICIPANTS Chinese school-children aged 12 to 17 years. METHODS Children with uncorrected visual acuity ≤ 6/12 in either eye underwent measurement of the logarithm of the minimum angle of resolution visual acuity, habitual correction, self-refraction without cycloplegia, autorefraction with and without cycloplegia, and subjective refraction with cycloplegia. MAIN OUTCOME MEASURES Proportion of children achieving corrected visual acuity ≥ 6/7.5 with each modality; difference in spherical equivalent refractive error between each of the modalities and cycloplegic subjective refractive error. RESULTS Among 556 eligible children of consenting parents, 554 (99.6%) completed self-refraction (mean age, 13.8 years; 59.7% girls; 54.0% currently wearing glasses). The proportion of children with visual acuity ≥ 6/7.5 in the better eye with habitual correction, self-refraction, noncycloplegic autorefraction, and cycloplegic subjective refraction were 34.8%, 92.4%, 99.5% and 99.8%, respectively (self-refraction versus cycloplegic subjective refraction, P<0.001). The mean difference between cycloplegic subjective refraction and noncycloplegic autorefraction (which was more myopic) was significant (-0.328 diopter [D]; Wilcoxon signed-rank test P<0.001), whereas cycloplegic subjective refraction and self-refraction did not differ significantly (-0.009 D; Wilcoxon signed-rank test P = 0.33). Spherical equivalent differed by ≥ 1.0 D in either direction from cycloplegic subjective refraction more frequently among right eyes for self-refraction (11.2%) than noncycloplegic autorefraction (6.0%; P = 0.002). Self-refraction power that differed by ≥ 1.0 D from cycloplegic subjective refractive error (11.2%) was significantly associated with presenting without spectacles (P = 0.011) and with greater absolute power of both spherical (P = 0.025) and cylindrical (P = 0.022) refractive error. CONCLUSIONS Self-refraction seems to be less prone to accommodative inaccuracy than noncycloplegic autorefraction, another modality appropriate for use in areas where access to eye care providers is limited. Visual results seem to be comparable. Greater cylindrical power is associated with less accurate results; the adjustable glasses used in this study cannot correct astigmatism. Further studies of the practical applications of this modality are warranted. FINANCIAL DISCLOSURE(S) Proprietary or commercial disclosure may be found after the references.


BMJ | 2008

Apply psychology and education

Graeme Mackenzie

I am a full time, out of hours general practitioner. I admit patients to hospital for two reasons.1 Firstly, if my top differential diagnosis has a illness trajectory that might result in the patient coming to harm if he or she is not admitted. Secondly, if the functional state of the patient is such that …


BMJ | 2006

Referral management centres: general practitioner colleagues could refer among themselves.

Graeme Mackenzie

EDITOR—I have no real objections to my referrals being triaged by clinicians.1 Iam under no illusions that referral is used as an “option” for general practitioners, and that we use it sometimes inappropriately just to be seen to be doing something. Of course medicolegally it is a powerful defence, …


BMJ | 2005

Old docs and new tricks: Efficiency is important.

Graeme Mackenzie

Editor—In British general practice, where everyday demand exceeds capacity, the efficient general practitioner is king. That is one thing that experience should bring. If all general practitioners followed every guideline the system would collapse, and although a few patients would have exemplary care, many would have no care at all as they would just not get seen because they would find the wait intolerable. Perhaps this is what happens now in secondary care, where care delivered is often very good but access is less and less. Accepted practice is often developed for a “one issue patient.” Reality means multi-issue patients, who themselves have limited ability to follow all the investigation and “treatment” recommended by the single issue academic establishment. Many indications for treatment are immediately met with contraindications. Experience allows general practitioners to cut back on too much excess investigation and treatment while still striving to meet the guidelines. Protecting the patient from the iatrogenic harm of excess health care used to be a core skill of the general practitioner. Is this being taken away from us as well? A system that fails to value the soft end points and often efficient and effective care that experience brings will have to restructure to meet the demand and that inevitably will lead to a hugely expanded system with resource implications. I am not disputing the findings of the paper reported by Spurgeon, that the standard of care may drop with years spent in practice,1 but the immediate common sense illogically of its hypothesis and conclusions make me advise to proceed down this route with caution. Being a doctor is already a difficult job. Being advised that all your thoughtful patient experience has actually made you a worse doctor is demotivating. Perhaps experienced doctors and patients would have a different set of criteria about what good care is?


BMJ | 2003

RAPID RESPONSES FROM BMJ.COM: Corticosteroid injections work!

Graeme Mackenzie

general practice. Fourth national study 1991-1992. London: HMSO, 1993. (Series MB5 No 3.) 3. Van der Windt DAWM, Koes BW, Boeke AJP, Deville W, de Jong BA, Bouter LM. Shoulder disorders in general practice: prognostic indicators of outcome. Br J Gen Pract 1996;46:519-523. 4. Vecchio P, Kavanagh R, Hazleman BL, King RH. Shoulder pain in a community based rheumatology clinic. Br J Rheumatol 1995;34:440-442. 5. Nygren A, Berglund A, Von Koch M. Neck and shoulder pain: an increasing problem. Strategies for using insurance material to follow trends. Scand J Rehabil Med Suppl 1995;32:107-112. 6. Sackett DL, Haynes RB, Guyatt GH, Tugwell P. Clinical epidemiology: a basic science for clinical medicine. 2nd ed. Philadelphia, PA: Lippincott, Williams, and Wilkins; 1991. 7. Josza J, Kannus P. Structure and metabolism of normal tendons. In: Human tendons. New York: Human Kinetics; 1997:46-95. 8. Curwin SL. The aetiology and treatment of tendinitis. In: Harries M, Williams C, Stannish WD, Micheli LJ, eds. Oxford textbook of sports medicine. Oxford: Oxford University Press; 1994:512-528. 9. Josza J, Kannus P. Overuse injuries of tendons. In: Human tendons. New York: Human Kinetics; 1997:164-253. 10. Alfredson H. In situ microdialysis in tendon tissue: high levels of glutamate, but not prostaglandin E2 in chronic achilles tendon pain. Knee Surg Sports Traumatol Arthrosc 1999;7:378-381. 11. Riley GP, Harrall RL, Constant CR, Chard MD, Cawston TE, Hazleman BL. Tendon degeneration and chronic shoulder pain: changes in collagen composition of the human rotator cuff tendons in rotator cuff tendinitis. Annals Rheum Dis 1994;53:359-366. 12. Chard MD, Cawston TE, Riley GP, Gresham GA, Hazleman BL. Rotator cuff degeneration and lateral epicondylitis: a comparative histological study. Ann Rheum Dis 1994;53:30-34. 13. Kannus P, Jozsa L. Histopathological changes preceding spontaneous rupture of a tendon. A controlled study of 891 patients. J Bone Joint Surg (Am) 1991;73:1507-1525. 14. Almekinders LC, Temple JD. Etiology, diagnosis and treatment of tendonitis: an analysis of the literature. Med Sci Sports Exerc 1998;30:1183-1190. 15. Khan KM, Cook JL, Maffulli N, Kannus P. Where is the pain coming from in tendinopathy? It may be biochemical, not only structural in origin. Br J Sports Med 2000;34:81-83. 16. Gotoh M, Hamada K, Yamakawa H, Inoue A, Fukoda H, et al. Increased substance P in subacromial bursa and shoulder pain in rotator cuff disease. J Orthop Res 1998;16:618-621. 17. Benazzo F, Stennardo G, Valli M. Achilles’ and patellar tendinopathies in athletes: pathogenesis and surgical treatment. Bull Hosp Joint Dis 1996;54:236-240. 18. Consumers’ Association. Articular and periarticular corticosteroid injections. Drugs Ther Bull 1995;33:67-70. 19. Wong ME, Hollinger JO, Pinero GJ. Integrated processes responsible for soft tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996;82:475-492. 20.Kapetanos G. The effect of the local corticosteroids on the healing and biomechanical properties of the partially injured tendon. Clin Orthop 1982;163:170-179. 21. Ketchum LD. Effects of triamcinalone on tendon healing and function. Plast Reconstr Surg 1971;47:471. 22.Unverfirth LJ, Olix ML. The effect of local steroid injections on tendon. J Bone Joint Surg (Am) 1973;55:1315. 23.Gottlieb NL, Riskin WG. Complications of local corticosteroid injections. JAMA 1980;240:1547-1548. 24.Murphy D, Failla JM, Koniuch MP. Steroid versus placebo injection for trigger finger. J Hand Surg 1995;20A:628-631. 25.Lambert MA, Morton RJ, Sloan JP. Controlled study of the use of local steroid injection in the treatment of trigger finger and thumb. J Hand Surg 1992;17B:69-70. 26.Green S, Buchbinder R, Glazier R, Forbes A. Interventions for shoulder pain. Cochrane Database Syst Rev 2000;(2):CD001156. 27. Speed CA, Hazleman BL. Shoulder pain. Clinical evidence. London: BMJ; 2000. (Issue 4.) 28.Petri M, Dobrow R, Neiman R, Whiting-O’Keefe Q, Seaman WE. Randomised double blind placebo controlled study of the treatment of the painful shoulder. Arthritis Rheum 1987;30:10401045. 29.Adebajo AO, Nash P, Hazleman BL. A prospective double blind dummy placebo controlled study comparing triamcinolone hexacetonide injection with oral diclofenac 50 mg tds in patients with rotator cuff tendinitis. J Rheumatol 1990;17:12071210. 30.Vecchio PC, Hazleman BL, King RH. A double blind trial comparing subacromial methylprednisolone and lignocaine in acute rotator cuff tendinitis. Br J Rheumatol 1993;32:743-745. 31. Assendelft WJ, Hay EM, Adshead R, Bouter LM. Corticosteroid injections for lateral epicondylitis: a systematic overview. Br J Gen Pract 1996;46:209-216. 32.Hay EM, Paterson SM, Lewis M, Hosie G, Croft P. Pragmatic randomised controlled trial of local corticosteroid injection and naproxen for treatment of lateral epicondylitis of elbow in primary care. BMJ 1999;319:964-968. 33.DaCruz DJ, Geeson M, Allen MJ, Phair I. Achilles’ paratendonitis: an evaluation of steroid injection. Br J Sports Med 1988;22:64-65. 34.Eustace JA, Brophy DP, Gibney RP, Bresnihan B, FitzGerald O. Comparison of the accuracy of steroid placement with clinical outcome in patients with shoulder symptoms. Ann Rheum Dis 1997;56:59-63. 35.Zhingis C, Failla JM, Van Holsbeeck M. Injection accuracy and clinical relief of de Quervain’s tendinitis. J Hand Surg 1998; 23A:89-96. 36.Balint P, Sturrock RD. Musculoskeletal ultrasound imaging: a new diagnostic tool for the rheumatologist? Br J Rheum 1997; 36:1141-1142. 37. Haslock I, Macfarlane D, Speed C. Intra-articular and soft tissue injections: a survey of current practice. Br J Rheum 1995;34:449452. 38. Josza J, Kannus P. Treatment principles in tendon injuries and other tendon disorders. In: Human tendons. New York: Human Kinetics; 1997:491-525. 39.Appell H-J. Muscular atrophy following immobilisation: a review. Sports Med 1990;10:42-58. 40.Kannus P, Jarvinen M, Niittymaki S. Longor short-acting anesthetic with corticosteroid in local injections of overuse injuries? A prospective, randomised, double-blind study. Int J Sports Med 1990;11:397-400. 41. Mattila J. Prolonged action and sustained serum levels of methylprednisolone acetate. Clin Trials J 1983;20:18-23.


BMJ | 2002

Non-cardiac chest pain

David S. Coulshed; Nicholas J. Talley; Graeme Mackenzie


BMJ | 1997

The caring doctor is an oxymoron

Graeme Mackenzie


The Lancet Global Health | 2018

Effect of providing near glasses on productivity among rural Indian tea workers with presbyopia (PROSPER): a randomised trial

Priya Reddy; Nathan Congdon; Graeme Mackenzie; Parikshit Gogate; Qing Wen; Catherine Jan; Mike Clarke; Jordan Kassalow; Ella Gudwin; Ciaran O'Neill; Ling Jin; Jianjun Tang; Ken Bassett; David H Cherwek; Rahul Ali


BMJ | 2006

Referral management centres

David J. Keene; Graeme Mackenzie

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Mike Clarke

Queen's University Belfast

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Qing Wen

Queen's University Belfast

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Leon B. Ellwein

National Institutes of Health

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Ciaran O'Neill

Queen's University Belfast

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Jianjun Tang

Queen's University Belfast

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