Is this you? Create Your Porfile
Avatar

Gregory A. Rener

Southern Research Institute

Network

Latest external collaboration on country level. Dive into details by clicking on the dots.

Explore More

Hotspot

Dive into the research topics where Gregory A. Rener is active.

Explore More

Publication

Featured researches published by Gregory A. Rener.

Advances in Experimental Medicine and Biology | 1993

Tubulin Binding Properties of Two Chiral Isomers with 1-Deaza-7, 8-Dihydropteridine Structure

Daniel Leynadier; Vincent Peyrot; Marcel Sarrazin; Caroll Temple; Gregory A. Rener; Claudette Briand

It has been shown that ethyl 5-amino-l,2-dihydro-2-methyl-3-phenyl pyrido (3,4-b)pyrazin-7-yl carbamate (NSC 370147) inhibits microtubule formation, that this racemic compound binds to tubulin at or near the colchicine site, and that it enhances the binding of Vincristine to tubulin1. It appeared of interest to evaluate the activity of the R-enantiomer (NSC 613863) and the S-enantiomer (NSC 613862, CI 980). Hence, their interactions were examined at molecular level. Furthermore, we compared the binding properties of these new compounds to those of colchicine and colchicine analogues, which are firmly established. The influence of chirality on the polymerization of microtubule proteins and tubulin is also discussed.

Cancer Research | 1994

Inhibition of Microtubules and Cell Cycle Arrest by a New 1-Deaza-7,8-dihydropteridine Antitumor Drug, CI 980, and by Its Chiral Isomer, NSC 613863

Concepción de Inés; Daniel Leynadier; Isabel Barasoain; Vincent Peyrot; Patrick L. Garcia; Claudette Briand; Gregory A. Rener; Carroll Temple

Journal of Medicinal Chemistry | 1987

Synthesis of potential anticancer agents: imidazo[4,5-c]pyridines and imidazo[4,5-b]pyridines

Carroll Temple; Jerry D. Rose; Robert N. Comber; Gregory A. Rener

Journal of Medicinal Chemistry | 1992

Antimitotic agents: structure-activity studies with some pyridine derivatives.

Carroll Temple; Gregory A. Rener; William R. Waud; Patricia E. Noker

Journal of Medicinal Chemistry | 1994

Phosphonate Analogs of Carbocyclic Nucleotides

Robert D. Elliott; Gregory A. Rener; James M. Riordan; John A. Secrist; L. Lee Bennett; William B. Parker; John A. Montgomery

Journal of Medicinal Chemistry | 1989

New anticancer agents: alterations of the carbamate group of ethyl (5-amino-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl)carbamates

Carroll Temple; Gregory A. Rener; Robert N. Comber

Biochemistry | 1993

Tubulin binding of two 1-deaza-7,8-dihydropteridines with different biological properties: enantiomers NSC 613862 (S)-(-) and NSC 613863 (R)-(+).

Daniel Leynadier; Vincent Peyrot; Marcel Sarrazin; Claudette Briand; Gregory A. Rener; Caroll Temple

Biochemistry | 1995

Differential effects of ethyl 5-amino-2-methyl-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl carbamate analogs modified at position C2 on tubulin polymerization, binding, and conformational changes.

Pascale Barbier; Vincent Peyrot; Marcel Sarrazin; Gregory A. Rener; Claudette Briand

Journal of Medicinal Chemistry | 1989

New anticancer agents: chiral isomers of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine-7-carbamate

Carroll Temple; Gregory A. Rener

Journal of Medicinal Chemistry | 1990

Potential antimitotic agents. Synthesis of some ethyl benzopyrazin-7-ylcarbamates, ethyl pyrido[3,4-b]pyrazin-7-ylcarbamates, and ethyl pyrido[3,4-e]-as-triazin-7-ylcarbamates.

Carroll Temple; Gregory A. Rener

Explore More

Collaboration

Dive into the Gregory A. Rener's collaboration.

Top Co-Authors
Avatar

Carroll Temple

Southern Research Institute

View shared research outputs
Top Co-Authors
Avatar

Vincent Peyrot

Aix-Marseille University

View shared research outputs
Top Co-Authors
Avatar

Robert N. Comber

Southern Research Institute

View shared research outputs
Top Co-Authors
Avatar

Caroll Temple

Southern Research Institute

View shared research outputs
Top Co-Authors
Avatar

William R. Waud

Southern Research Institute

View shared research outputs
Top Co-Authors
Avatar

Claudette Briand

Centre national de la recherche scientifique

View shared research outputs
Top Co-Authors
Avatar

Claudette Briand

Centre national de la recherche scientifique

View shared research outputs
Top Co-Authors
Avatar

James M. Riordan

University of Alabama at Birmingham

View shared research outputs
Top Co-Authors
Avatar

Jerry D. Rose

Southern Research Institute

View shared research outputs
Top Co-Authors
Avatar

John A. Montgomery

Southern Research Institute

View shared research outputs
Explore More
Researchain Logo
Decentralizing Knowledge