Gregory Chudzik

Drug interaction. An important consideration for rational pediatric therapy.

In its broadest sense, drug interaction may refer not only to the reaction between two or more therapeutic agents, but also to the interplay between an administered agent and a component of the host. Thus we may have drug-drug and drug-food interactions, and drug interactions with a particular clinical condition. The latter is particularly true in the rapidly growing infant or child, where host factors may result in qualitative as well as quantitative differences in drug interactions.

Stevens-Johnson Syndrome Associated with Diphenylhydantoin Therapy a Case Report

.... K.M., a nine-year-old white male was presented to the Buffalo Childrens Hospital with a chief complaint of soreness of the gums and fever for five days prior to admission. This soreness and fever were followed 4 days prior to admission, by the development of sore~ on the lips and rash which started on the abdomen and back and spread to the rest of the body. Three days prior to admission his temperature was 40.5 ° C and he experienced increased anorexia and dysphagia. At this