Gregory G. Tamer

Modeling hemodynamic responses in auditory cortex at 1.5 T using variable duration imaging acoustic noise

A confound for functional magnetic resonance imaging (fMRI), especially for auditory studies, is the presence of imaging acoustic noise generated mainly as a byproduct of rapid gradient switching during volume acquisition and, to a lesser extent, the radiofrequency transmit. This work utilized a novel pulse sequence to present actual imaging acoustic noise for characterization of the induced hemodynamic responses and assessment of linearity in the primary auditory cortex with respect to noise duration. Results show that responses to brief duration (46 ms) imaging acoustic noise is highly nonlinear while responses to longer duration (>1 s) imaging acoustic noise becomes approximately linear, with the right primary auditory cortex exhibiting a higher degree of nonlinearity than the left for the investigated noise durations. This study also assessed the spatial extent of activation induced by imaging acoustic noise, showing that the use of modeled responses (specific to imaging acoustic noise) as the reference waveform revealed additional activations in the auditory cortex not observed with a canonical gamma variate reference waveform, suggesting an improvement in detection sensitivity for imaging acoustic noise-induced activity. Longer duration (1.5 s) imaging acoustic noise was observed to induce activity that expanded outwards from Heschls gyrus to cover the superior temporal gyrus as well as parts of the middle temporal gyrus and insula, potentially affecting higher level acoustic processing.

Assessment of Temporal State-Dependent Interactions between Auditory fMRI Responses to Desired and Undesired Acoustic Sources

A confounding factor in auditory functional magnetic resonance imaging (fMRI) experiments is the presence of the acoustic noise inherently associated with the echo planar imaging acquisition technique. Previous studies have demonstrated that this noise can induce unwanted neuronal responses that can mask stimulus-induced responses. Similarly, activation accumulated over multiple stimuli has been demonstrated to elevate the baseline, thus reducing the dynamic range available for subsequent responses. To best evaluate responses to auditory stimuli, it is necessary to account for the presence of all recent acoustic stimulation, beginning with an understanding of the attenuating effects brought about by interaction between and among induced unwanted neuronal responses, and responses to desired auditory stimuli. This study focuses on the characterization of the duration of this temporal memory and qualitative assessment of the associated response attenuation. Two experimental parameters--inter-stimulus interval (ISI) and repetition time (TR)--were varied during an fMRI experiment in which participants were asked to passively attend to an auditory stimulus. Results present evidence of a state-dependent interaction between induced responses. As expected, attenuating effects of these interactions become less significant as TR and ISI increase and in contrast to previous work, persist up to 18s after a stimulus presentation.

Characterizing Response to Elemental Unit of Acoustic Imaging Noise: An fMRI Study

Acoustic imaging noise produced during functional magnetic resonance imaging (fMRI) studies can hinder auditory fMRI research analysis by altering the properties of the acquired time-series data. Acoustic imaging noise can be especially confounding when estimating the time course of the hemodynamic response (HDR) in auditory event-related fMRI (fMRI) experiments. This study is motivated by the desire to establish a baseline function that can serve not only as a comparison to other quantities of acoustic imaging noise for determining how detrimental is ones experimental noise, but also as a foundation for a model that compensates for the response to acoustic imaging noise. Therefore, the amplitude and spatial extent of the HDR to the elemental unit of acoustic imaging noise (i.e., a single ping) associated with echoplanar acquisition were characterized and modeled. Results from this fMRI study at 1.5 T indicate that the group-averaged HDR in left and right auditory cortex to acoustic imaging noise (duration of 46 ms) has an estimated peak magnitude of 0.29% (right) to 0.48% (left) signal change from baseline, peaks between 3 and 5 s after stimulus presentation, and returns to baseline and remains within the noise range approximately 8 s after stimulus presentation.

Effects of Dietary Protein and Fiber at Breakfast on Appetite, ad Libitum Energy Intake at Lunch, and Neural Responses to Visual Food Stimuli in Overweight Adults

Increasing either protein or fiber at mealtimes has relatively modest effects on ingestive behavior. Whether protein and fiber have additive or interactive effects on ingestive behavior is not known. Fifteen overweight adults (5 female, 10 male; BMI: 27.1 ± 0.2 kg/m2; aged 26 ± 1 year) consumed four breakfast meals in a randomized crossover manner (normal protein (12 g) + normal fiber (2 g), normal protein (12 g) + high fiber (8 g), high protein (25 g) + normal fiber (2 g), high protein (25 g) + high fiber (8 g)). The amount of protein and fiber consumed at breakfast did not influence postprandial appetite or ad libitum energy intake at lunch. In the fasting-state, visual food stimuli elicited significant responses in the bilateral insula and amygdala and left orbitofrontal cortex. Contrary to our hypotheses, postprandial right insula responses were lower after consuming normal protein vs. high protein breakfasts. Postprandial responses in other a priori brain regions were not significantly influenced by protein or fiber intake at breakfast. In conclusion, these data do not support increasing dietary protein and fiber at breakfast as effective strategies for modulating neural reward processing and acute ingestive behavior in overweight adults.

Reproducibility assessment of brain responses to visual food stimuli in adults with overweight and obesity.

The brains reward system influences ingestive behavior and subsequently obesity risk. Functional magnetic resonance imaging (fMRI) is a common method for investigating brain reward function. This study sought to assess the reproducibility of fasting‐state brain responses to visual food stimuli using BOLD fMRI.

Signal fluctuations induced by non-T1-related confounds in variable TR fMRI experiments

To assess and model signal fluctuations induced by non‐T1‐related confounds in variable repetition time (TR) functional magnetic resonance imaging (fMRI) and to develop a compensation procedure to correct for the non‐T1‐related artifacts.

Characterizing the attenuation and/or saturation effect of the acoustic scanner noise in auditory event-related functional magnetic resonance imaging

The analysis of event-related functional magnetic resonance imaging when presenting auditory stimuli and/or investigating auditory cortex and related areas is hindered by inherent acoustic scanner noise (ASN), which can alter the properties of the acquired time-series data. Therefore, it is necessary to account for ASN in the analysis, and one step towards this goal is to characterize the attenuation and/or saturation effect of the hemodynamic response due to ASN. Towards this end, this study examined how the effect of ASN is dependent on repetition time (TR) and the inter-stimulus interval (ISI), two experimental parameters that affect the acoustic signal-to-noise ratio of the experimental paradigm. Results indicate that a decrease in TR (e.g., 6 s to 1.5 s) results in an increase in saturation and an attenuation of the estimated hemodynamic response peak with respect to the baseline signal level. There was no statistical difference in peak response between the two ISI values used, 12 s and 18 s.

Consuming Almonds vs. Isoenergetic Baked Food Does Not Differentially Influence Postprandial Appetite or Neural Reward Responses to Visual Food Stimuli

Nuts have high energy and fat contents, but nut intake does not promote weight gain or obesity, which may be partially explained by their proposed high satiety value. The primary aim of this study was to assess the effects of consuming almonds versus a baked food on postprandial appetite and neural responses to visual food stimuli. Twenty-two adults (19 women and 3 men) with a BMI between 25 and 40 kg/m2 completed the current study during a 12-week behavioral weight loss intervention. Participants consumed either 28 g of whole, lightly salted roasted almonds or a serving of a baked food with equivalent energy and macronutrient contents in random order on two testing days prior to and at the end of the intervention. Pre- and postprandial appetite ratings and functional magnetic resonance imaging scans were completed on all four testing days. Postprandial hunger, desire to eat, fullness, and neural responses to visual food stimuli were not different following consumption of almonds and the baked food, nor were they influenced by weight loss. These results support energy and macronutrient contents as principal determinants of postprandial appetite and do not support a unique satiety effect of almonds independent of these variables.

Measurement of auditory hemodynamic response function due to different temporal patterns of imaging acoustic noise using functional magnetic resonance imaging

Imaging acoustic noise (IAN) is a confounding factor that undermines the usefulness of functional magnetic resonance imaging (fMRI), especially in auditory related experiments. This paper presents the methods and results of measuring auditory hemodynamic responses (HDR) due to different temporal patterns of IAN using fMRI. Six different temporal patterns of IAN corresponding to acoustic noise generated while using different numbers of imaging slices and effective repetition times (TR) were used as stimuli in the current study. Hemodynamic responses were measured using a stroboscopic event related paradigm with extra long TRs to minimize the effects due to previous IAN segments. The shape of the HDR and the extent of activation due to each of the above stimuli are reported here and are in agreement with those reported in previous studies. In addition to the responses due to IAN patterns reported in previous studies, responses to several new temporal patterns are also reported here. The results of this study will be used in developing a model-based correction algorithm to account for IAN in auditory fMRI.

Trial modeling of the hemodynamic response using event-related fMRI

Investigates the modeling of the intra-run trials within auditory event-related fMRI experiments. Building upon previously accepted techniques and models, a new, less rigid model is presented that allows for the estimation of the hemodynamic response across a much larger set of timepoints. This is accomplished by avoiding the reduction of timepoints that occurs when using trial averaging techniques. Instead, variations between trials are incorporated into a new model while still preserving the general characteristics of the response. The addition of a trial-dependent proportionality factor in the model significantly increases the accuracy of the coefficients estimated through a nonlinear least squares regression.