Gregory Hartlage
University of South Florida
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Gregory Hartlage.
Journal of Cardiac Failure | 2009
Maya Guglin; Gregory Hartlage; Christopher Reynolds; Ren Chen; Vinod Patel
BACKGROUND One of the recent advances in the treatment of breast cancer is trastuzumab. However, a major side effect of this medication is cardiomyopathy. Our objective was to determine the incidence of trastuzumab-induced cardiomyopathy and the rate of discontinuation of trastuzumab in a clinical setting. METHODS AND RESULTS We retrospectively reviewed the records of all women treated with trastuzumab at the Moffitt Cancer Center between 2003 and 2007. Cardiomyopathy was defined as symptomatic heart failure or a decrease of ejection fraction by >or=10% from baseline or to <50%. Statistical analysis was done with Fisher exact test, t-test test, and Wilcoxon signed rank test. Cardiomyopathy developed in 52 of 156 (33.3%) of patients being treated with trastuzumab. In the adjuvant group, 23 (19.5%) of women permanently or temporarily discontinued therapy secondary to cardiomyopathy. CONCLUSIONS Cardiomyopathy is a common side effect of trastuzumab that leads to discontinuation of treatment in a significant proportion of patients. Further studies are indicated to establish the ways to predict, prevent, and treat cardiomyopathy to provide patients with maximal therapeutic benefit of trastuzumab.
Journal of Cardiac Failure | 2016
Daniel J. Lenihan; Gregory Hartlage; Jeanne M. DeCara; Anne H. Blaes; J. Emanuel Finet; Alexander R. Lyon; Robert F. Cornell; Javid Moslehi; Guilherme H. Oliveira; Gillian Murtagh; Michael J. Fisch; Gary Zeevi; Zaza Iakobishvili; Ron Witteles; Aarti Patel; Eric E. Harrison; Michael G. Fradley; Giuseppe Curigliano; Carrie Geisberg Lenneman; Andreia Magalhães; Ron Krone; Charles B. Porter; Susmita Parasher; Susan Dent; Pamela S. Douglas; Joseph R. Carver
There is an increasing awareness and clinical interest in cardiac safety during cancer therapy as well as in optimally addressing cardiac issues in cancer survivors. Although there is an emerging expertise in this area, known as cardio-oncology, there is a lack of organization in the essential components of contemporary training. This proposal, an international consensus statement organized by the International Cardioncology Society and the Canadian Cardiac Oncology Network, attempts to marshal the important ongoing efforts for training the next generation of cardio-oncologists. The necessary elements are outlined, including the expectations for exposure necessary to develop adequate training. There should also be a commitment to local, regional, and international education and research in cardio-oncology as a requirement for advancement in the field.
Oncology Reviews | 2017
Michael G. Fradley; Allen Brown; Bernadette Shields; Federico Viganego; Rongras Damrongwatanasuk; Aarti Patel; Gregory Hartlage; Natalee Roper; Julie Jaunese; Larry Roy; Roohi Ismail-Khan
Cardio-oncology is a multidisciplinary field focusing on the management and prevention of cardiovascular complications in cancer patients and survivors. While the initial focus of this specialty was on heart failure associated with anthracycline use, novel anticancer agents are increasingly utilized and are associated with many other cardiotoxicities including hypertension, arrhythmias and vascular disease. Since its inception, the field has developed at a rapid pace with the establishment of programs at many major academic institutions and community practices. Given the complexities of this patient population, it is important for providers to possess knowledge of not only cardiovascular disease but also cancer subtypes and their specific therapeutics. Developing a cardio-oncology program at a stand-alone cancer center can present unique opportunities and challenges when compared to those affiliated with other institutions including resource allocation, cardiovascular testing availability and provider education. In this review, we present our experiences establishing the cardio-oncology program at Moffitt Cancer Center and provide guidance to those individuals interested in developing a program at a similar independent cancer institution.
Texas Heart Institute Journal | 2015
Vasilis Babaliaros; Stamatios Lerakis; Vinod H. Thourani; Sebastian Iturra; Gregory Hartlage; Farheen Shirazi; Stephen D. Clements
Pseudoaneurysm of the mitral-aortic intervalvular fibrosa is a rare but serious sequela of endocarditis or valve replacement surgery. Because open-heart surgery is a high-risk treatment option, alternative methods are sought. We present the case of a 77-year-old man with a noninfected mechanical mitral valve whose pseudoaneurysm was repaired by introducing an occluder device into the defect by a transapical approach. Upon follow-up imaging, the defect was successfully closed. We conclude that percutaneous closure of pseudoaneurysm of the mitral-aortic intervalvular fibrosa is a viable alternative to surgery and that a transapical approach is an appropriate method of access.
OncoReview | 2014
Gregory Hartlage; Palmer H. Cole; Aarti Patel; C. Alberto Morales; Eric E. Harrison
We report the case of a 66-year-old African American female with a history of breast cancer previously treated with anthracycline based chemotherapy presenting with significant mitral regurgitation. She initially had preserved left ventricular systolic function with normal cardiac chamber dimensions, however, she developed progressive left ventricular chamber dilation and mild reduction in systolic function, which prompted surgical correction of her mitral regurgitation. After surgical mitral valve repair, she developed overt left ventricular failure with severe systolic dysfunction; however, she responded well to subsequent medical therapy.
Journal of the American College of Cardiology | 2014
Gregory Hartlage; Jonathan D. Suever; Stephanie Clement-Guinaudeau; Patrick T. Strickland; Patrick Magrath; John N. Oshinski; Michael S. Lloyd
Patients undergoing cardiac resynchronization therapy (CRT) have higher response rates if they have typical left bundle branch block (LBBB) with QRS durations of >150ms. However, the benefits of CRT are less certain in those with wide QRS without classic LBBB or in those with QRS duration <150ms.
Case reports in vascular medicine | 2017
Sujoy Phookan; Patrick T. Strickland; Bishoy Hanna; Gregory Hartlage; Ankit Parikh; Stephen D. Clements
The differential diagnosis of a lateral neck mass includes a number of possible etiologies. While jugular venous aneurysms and pseudoaneurysms are rare entities, they should be considered in the differential diagnosis of a pulsatile lateral neck mass. We present a case of an idiopathic jugular venous pseudoaneurysm and its association with worsening tricuspid regurgitation in a patient with heart failure with preserved ejection fraction.
Case reports in cardiology | 2016
Asma Mursleen; Gregory Hartlage; Aarti Patel; Eric E. Harrison; C. Alberto Morales
Coronary anomalies can be observed in 1–1.2% of all angiograms performed. Majority of coronary anomalies are benign and do not lead to cardiac ischemia; however anomalous coronary arteries from the opposite sinus (ACAOS) are often associated with sudden cardiac deaths, typically in 0.11–0.35% of individuals who participate in vigorous physical activity (Peñalver et al., 2012). Left and right ACAOS have an incidence of 0.15% and 0.92%, respectively. Left ACAOS are often associated with higher incidence of sudden cardiac death; this could be secondary to greater territory of myocardial perfusion by the left coronary artery. ACAOS are often asymptomatic and initially present as sudden death following exertion in young athletes. The management of left ACAOS is clear and surgery is usually indicated. However there is a lack of consensus on the management of certain cases of right ACAOS. In this paper a case of 20 yo M with right coronary artery from left sinus is going to be presented with a discussion on pathophysiology, diagnosis, and management.
Journal of the American College of Cardiology | 2014
Salim Hayek; Arash Harzand; Jeh-wei Cheng; Gregory Hartlage; Sharon Howell; Xiao Zhou; Vasilis Babaliaros; Vinod H. Thourani; Stamatios Lerakis
Patients with severe aortic stenosis and low mean transvalvular gradient have poor outcomes, with an estimated 30 day post-surgical Aortic Valve Replacement (AVR) mortality of 21%. Low Dose Dobutamine Stress Echocardiography (LD-DSE) is performed in these patients for further risk stratification by
Arthritis Care and Research | 2013
Michelle J. Ormseth; Aliza Lipson; Nikolaos Alexopoulos; Gregory Hartlage; Annette Oeser; Aihua Bian; Tebeb Gebretsadik; Ayumi Shintani; Paolo Raggi; C. Michael Stein
Patients with rheumatoid arthritis (RA) have increased coronary atherosclerosis possibly related to increased prevalence of visceral adiposity, insulin resistance, and metabolic syndrome. Epicardial adipose tissue (EAT), a type of visceral fat, may contribute to cardiometabolic risk. The aim of this study was to measure EAT volume in patients with RA and determine its relationship with cardiometabolic risk markers and coronary artery calcium.