Gregory S. Ahearn
Duke University
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Featured researches published by Gregory S. Ahearn.
Chest | 2004
David B. Badesch; Steve H. Abman; Gregory S. Ahearn; Robyn J. Barst; Douglas C McCrory; Gérald Simonneau; Vallerie V. McLaughlin
Pulmonary arterial hypertension (PAH) is often difficult to diagnose and challenging to treat. Untreated, it is characterized by a progressive increase in pulmonary vascular resistance leading to right ventricular failure and death. The past decade has seen remarkable improvements in therapy, driven largely by the conduct of randomized controlled trials. Still, the selection of most appropriate therapy is complex, and requires familiarity with the disease process, evidence from treatment trials, complicated drug delivery systems, dosing regimens, side effects, and complications. This chapter will provide evidence-based treatment recommendations for physicians involved in the care of these complex patients. Due to the complexity of the diagnostic evaluation required, and the treatment options available, it is strongly recommended that consideration be given to referral of patients with PAH to a specialized center.
Proceedings of the National Academy of Sciences of the United States of America | 2007
James D. Reynolds; Gregory S. Ahearn; Michael Angelo; Jian Zhang; Fred R. Cobb; Jonathan S. Stamler
RBCs distribute oxygen to tissues, but, paradoxically, blood transfusion does not always improve oxygen delivery and is associated with ischemic events. We hypothesized that storage of blood would result in loss of NO bioactivity, impairing RBC vasodilation and thus compromising blood flow, and that repleting NO bioactivity would restore RBC function. We report that S-nitrosohemoglobin (SNO-Hb) concentrations declined rapidly after storage of fresh venous blood and that hypoxic vasodilation by banked RBCs correlated strongly with the amounts of SNO-Hb (r2 = 0.90; P < 0.0005). Renitrosylation of banked blood during storage increased the SNO-Hb content and restored its vasodilatory activity. In addition, canine coronary blood flow was greater during infusion of renitrosylated RBCs than during infusion of S-nitrosothiol-depleted RBCs, and this difference in coronary flow was accentuated by hypoxemia (P < 0.001). Our findings indicate that NO bioactivity is depleted in banked blood, impairing the vasodilatory response to hypoxia, and they suggest that SNO-Hb repletion may improve transfusion efficacy.
Chest | 2004
Vallerie V. McLaughlin; Kenneth W. Presberg; Ramona L. Doyle; Steven H. Abman; Douglas C McCrory; Terry Fortin; Gregory S. Ahearn
Chest | 2004
David B. Badesch; Steve H. Abman; Gregory S. Ahearn; Robyn J. Barst; Douglas C McCrory; Gérald Simonneau; Vallerie V. McLaughlin
Chest | 2004
Charles W. Atwood; Douglas C McCrory; Joe G. N. Garcia; Steven H. Abman; Gregory S. Ahearn
JAMA Internal Medicine | 2002
Gregory S. Ahearn; Denis Hadjiliadis; Joseph A. Govert; Victor F. Tapson
Proceedings of the National Academy of Sciences of the United States of America | 2005
Timothy J. McMahon; Gregory S. Ahearn; Martin P. Moya; Andrew J. Gow; Yuh-Chin T. Huang; Benjamin P. Luchsinger; Raphael Nudelman; Yun Yan; Abigail Krichman; Thomas M. Bashore; Robert M. Califf; David J. Singel; Claude A. Piantadosi; Victor F. Tapson; Jonathan S. Stamler
Chest | 2002
Gregory S. Ahearn; Victor F. Tapson; Abdallah G. Rebeiz; Joseph C. Greenfield
Archive | 2017
Gregory S. Ahearn; Denis Hadjiliadis; Joseph A. Govert; Victor F. Tapson
Journal of The American Academy of Dermatology | 2004
Sarah A. Myers; Gregory S. Ahearn; M. Angelica Selim; Victor F. Tapson