Gretchen Keel
National Institutes of Health
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Publication
Featured researches published by Gretchen Keel.
Journal of Clinical Oncology | 2012
Helen M. Parsons; Linda C. Harlan; Charles F. Lynch; Ann S. Hamilton; Xiao-Cheng Wu; Ikuko Kato; Stephen M. Schwartz; Ashley Wilder Smith; Gretchen Keel; Theresa H.M. Keegan
PURPOSE To examine the impact of cancer on work and education in a sample of adolescent and young adult (AYA) patients with cancer. PATIENTS AND METHODS By using the Adolescent and Young Adult Health Outcomes and Patient Experience Study (AYA HOPE)-a cohort of 463 recently diagnosed patients age 15 to 39 years with germ cell cancer, Hodgkins lymphoma, non-Hodgkins lymphoma, sarcoma, and acute lymphocytic leukemia from participating Surveillance, Epidemiology, and End Results (SEER) cancer registries-we evaluated factors associated with return to work/school after cancer diagnosis, a belief that cancer had a negative impact on plans for work/school, and reported problems with work/school after diagnosis by using descriptive statistics, χ(2) tests, and multivariate logistic regression. RESULTS More than 72% (282 of 388) of patients working or in school full-time before diagnosis had returned to full-time work or school 15 to 35 months postdiagnosis compared with 34% (14 of 41) of previously part-time workers/students, 7% (one of 14) of homemakers, and 25% (five of 20) of unemployed/disabled patients (P < .001). Among full-time workers/students before diagnosis, patients who were uninsured (odds ratio [OR], 0.21; 95% CI, 0.07 to 0.67; no insurance v employer-/school-sponsored insurance) or quit working directly after diagnosis (OR, 0.15; 95% CI, 0.06 to 0.37; quit v no change) were least likely to return. Very intensive cancer treatment and quitting work/school were associated with a belief that cancer negatively influenced plans for work/school. Finally, more than 50% of full-time workers/students reported problems with work/studies after diagnosis. CONCLUSION Although most AYA patients with cancer return to work after cancer, treatment intensity, not having insurance, and quitting work/school directly after diagnosis can influence work/educational outcomes. Future research should investigate underlying causes for these differences and best practices for effective transition of these cancer survivors to the workplace/school after treatment.
Frontiers in Oncology | 2013
Ashley Wilder Smith; Helen M. Parsons; Erin E. Kent; Keith M. Bellizzi; Brad Zebrack; Gretchen Keel; Charles F. Lynch; Mara B. Rubenstein; Theresa Hm Keegan; Rosemary D. Cress; Gretchen Agha; Mark Cruz; Stephen M. Schwartz; Martha Shellenberger; Tiffany Janes; Ikuko Kato; Ann Bankowski; Marjorie Stock; Xiao-Cheng Wu; Vivien W. Chen; Bradley J. Tompkins; Theresa H.M. Keegan; Laura Allen; Zinnia Loya; Karen Hussain; Michele M. West; Lori A. Odle; Ann S. Hamilton; Jennifer Zelaya; Mary Lo
Introduction: Cancer for adolescents and young adults (AYA) differs from younger and older patients; AYA face medical challenges while navigating social and developmental transitions. Research suggests that these patients are under or inadequately served by current support services, which may affect health-related quality of life (HRQOL). Methods: We examined unmet service needs and HRQOL in the National Cancer Institute’s Adolescent and Young Adult Health Outcomes and Patient Experience (AYA HOPE) study, a population-based cohort (n = 484), age 15–39, diagnosed with cancer 6–14 months prior, in 2007–2009. Unmet service needs were psychosocial, physical, spiritual, and financial services where respondents endorsed that they needed, but did not receive, a listed service. Linear regression models tested associations between any or specific unmet service needs and HRQOL, adjusting for demographic, medical, and health insurance variables. Results: Over one-third of respondents reported at least one unmet service need. The most common were financial (16%), mental health (15%), and support group (14%) services. Adjusted models showed that having any unmet service need was associated with worse overall HRQOL, fatigue, physical, emotional, social, and school/work functioning, and mental health (p’s < 0.0001). Specific unmet services were related to particular outcomes [e.g., needing pain management was associated with worse overall HRQOL, physical and social functioning (p’s < 0.001)]. Needing mental health services had the strongest associations with worse HRQOL outcomes; needing physical/occupational therapy was most consistently associated with poorer functioning across domains. Discussion: Unmet service needs in AYAs recently diagnosed with cancer are associated with worse HRQOL. Research should examine developmentally appropriate, relevant practices to improve access to services demonstrated to adversely impact HRQOL, particularly physical therapy and mental health services.
Journal of the National Cancer Institute | 2014
Arnold L. Potosky; Linda C. Harlan; Karen Albritton; Rosemary D. Cress; Debra L. Friedman; Ann S. Hamilton; Ikuko Kato; Theresa H.M. Keegan; Gretchen Keel; Stephen M. Schwartz; Nita L. Seibel; Margarett Shnorhavorian; Michele M. West; Xiao-Cheng Wu
BACKGROUND There has been little improvement in the survival of adolescent and young adult (AYA) cancer patients aged 15 to 39 years relative to other age groups, raising the question of whether such patients receive appropriate initial treatment. METHODS We examined receipt of initial cancer treatment for a population-based sample of 504 AYAs diagnosed in 2007-2008 with acute lymphoblastic leukemia (ALL), Hodgkins or non-Hodgkins lymphoma, germ cell cancer, or sarcoma. Registry data, patient surveys, and detailed medical record reviews were used to evaluate the association of patient demographic, socioeconomic, and health care setting characteristics with receipt of appropriate initial treatment, which was defined by clinical specialists in AYA oncology based on adult guidelines and published literature available before 2009 and analyzed with multivariable logistic regression. All statistical tests were two-sided. RESULTS Approximately 75% of AYA cancer patients in our sample received appropriate treatment, 68% after excluding stage I male germ cell patients who all received appropriate treatment. After this exclusion, appropriate treatment ranged from 79% of sarcoma patients to 56% of ALL patients. Cancer type (P < .01) and clinical trial participation (P = .04) were statistically significantly associated with appropriate treatment in multivariable analyses. Patients enrolled in clinical trials were more likely to receive appropriate therapy relative to those not enrolled (78% vs 67%, adjusted odds ratio = 2.6, 95% confidence interval = 1.1 to 6.4). CONCLUSIONS Except for those with early stage male germ cell tumors, approximately 30% (or 3 in 10) AYA cancer patients did not receive appropriate therapy. Further investigation is required to understand the reasons for this potential shortfall in care delivery.
Journal of Cancer Epidemiology | 2012
Keith M. Bellizzi; Noreen M. Aziz; Julia H. Rowland; Kathryn E. Weaver; Neeraj K. Arora; Ann S. Hamilton; Ingrid Oakley-Girvan; Gretchen Keel
Understanding the post-treatment physical and mental function of older adults from ethnic/racial minority backgrounds with cancer is a critical step to determine the services required to serve this growing population. The double jeopardy hypothesis suggests being a minority and old could have compounding effects on health. This population-based study examined the physical and mental function of older adults by age (mean age = 75.7, SD = 6.1), ethnicity/race, and cancer (breast, prostate, colorectal, and gynecologic) as well as interaction effects between age, ethnicity/race and HRQOL. There was evidence of a significant age by ethnicity/race interaction in physical function for breast, prostate and all sites combined, but the interaction became non-significant (for breast and all sites combined) when comorbidity was entered into the model. The interaction persisted in the prostate cancer group after controlling for comorbidity, such that African Americans and Asian Americans in the 75–79 age group report lower physical health than non-Hispanic Whites and Hispanic Whites in this age group. The presence of double jeopardy in the breast and all sites combined group can be explained by a differential comorbid burden among the older (75–79) minority group, but the interaction found in prostate cancer survivors does not reflect this differential comorbid burden.
Psycho-oncology | 2014
Laura P. Forsythe; Catherine M. Alfano; Erin E. Kent; Kathryn E. Weaver; Keith M. Bellizzi; Neeraj K. Arora; Noreen M. Aziz; Gretchen Keel; Julia H. Rowland
Cancer survivors play an important role in coordinating their follow‐up care and making treatment‐related decisions. Little is known about how modifiable factors such as social support are associated with active participation in follow‐up care. This study tests associations between social support, cancer‐related follow‐up care use, and self‐efficacy for participation in decision‐making related to follow‐up care (SEDM). We also identified sociodemographic and clinical factors associated with social support among long‐term survivors.
Journal of adolescent and young adult oncology | 2015
Helen M. Parsons; Linda C. Harlan; Susanne Schmidt; Theresa H.M. Keegan; Charles F. Lynch; Erin E. Kent; Xiao-Cheng Wu; Stephen M. Schwartz; Roland Chu; Gretchen Keel; Ashley Wilder Smith
PURPOSE Physicians play a critical role in delivering effective treatment and enabling successful transition to survivorship among adolescent and young adult (AYA) cancer patients. However, with no AYA cancer medical specialty, information on where and by whom AYAs with cancer are treated is limited. METHODS Using the National Cancer Institutes population-based AYA HOPE Study, 464 AYAs aged 15-39 at diagnosis treated by 903 physicians were identified. Differences in physician and hospital characteristics were examined by age at diagnosis and cancer type (germ cell cancer, non-Hodgkin lymphoma, Hodgkin lymphoma, acute lymphocytic leukemia [ALL], and sarcoma) using chi-square tests. RESULTS Treating physicians were predominately 51-64 years old, male, United States-trained in non-pediatric specialties, and in group practices within large metropolitan areas. Older patients were less often treated by pediatric physicians (p < 0.01) and more likely to be treated by United States-trained physicians without research/teaching responsibilities and in hospitals without residency programs (p < 0.05). The majority of the few pediatricians (n = 44) treated ALL patients. Physicians with research/teaching responsibilities and those based in medical schools were more likely to treat patients with ALL and sarcoma compared with other cancer types (p < 0.01). Of HL patients, 73% were treated at a cancer center compared with 56% of patients with germ cell cancer (p < 0.01), while ALL (85%) and sarcoma (87%) patients were more likely to be treated in hospitals with residency programs (p < 0.01). CONCLUSIONS Most AYAs with cancer were treated by non-pediatric physicians in community settings, although physician characteristics varied significantly by patient cancer type and age at diagnosis.
Journal of Cancer Survivorship | 2013
Kathryn E. Weaver; Randi E. Foraker; Catherine M. Alfano; Julia H. Rowland; Neeraj K. Arora; Keith M. Bellizzi; Ann S. Hamilton; Ingrid Oakley-Girvan; Gretchen Keel; Noreen M. Aziz
Cancer | 2015
Margarett Shnorhavorian; Linda C. Harlan; Ashley Wilder Smith; Theresa H.M. Keegan; Charles F. Lynch; Pinki K. Prasad; Rosemary D. Cress; Xiao-Cheng Wu; Ann S. Hamilton; Helen M. Parsons; Gretchen Keel; Sarah E. Charlesworth; Stephen M. Schwartz
Journal of Oncology Practice | 2014
Kathryn E. Weaver; Noreen M. Aziz; Neeraj K. Arora; Laura P. Forsythe; Ann S. Hamilton; Ingrid Oakley-Girvan; Gretchen Keel; Keith M. Bellizzi; Julia H. Rowland
Cancer Epidemiology, Biomarkers & Prevention | 2015
Xiao-Cheng Wu; Pinki K. Prasad; Ian Landry; Linda C. Harlan; Helen M. Parsons; Charles F. Lynch; Ashley Wilder Smith; Ann S. Hamilton; Theresa H.M. Keegan; Stephen M. Schwartz; Martha Shellenberger; Tiffany Janes; Michele M. West; Lori A. Somers; Ikuko Kato; Ann Bankowski; Marjorie Stock; Rosemary D. Cress; Gretchen Agha; Mark Cruz; Vivien W. Chen; Laura Allen; Zinnia Loya; Lisa Shelton-Herendeen; Jennifer Zelaya; Urduja Trinidad; Gretchen Keel; Jana Eisenstein; Arnold L. Potosky; Keith M. Bellizzi
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University of Texas Health Science Center at San Antonio
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