Guang-Pei Chen | Researchain

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Featured researches published by Guang-Pei Chen.

Tetrahedron Letters | 2002

Mechanism of the pinacol–pinacolone rearrangement of 2,3-di-(3-pyridyl)-2,3-butanediol in sulfuric acid

Eric Loeser; Guang-Pei Chen; Tao He; Kapa Prasad; Oljan Repic

Abstract The reaction of 2,3-di-(3-pyridyl)-2,3-butanediol ( 1 ) in H 2 SO 4 was studied. It was found that the meso and racemic forms give mono- and bis-SO 3 addition products, which rearrange to a ketone (Metopirone®) and two other major by-products. The formation of SO 3 addition products and a marked increase in reaction rates with greater amount of SO 3 suggest an alternate mechanism involving sulfonyloxy leaving groups.

Organic Process Research & Development | 2004

Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 4: Preparation of Fragment C7-24

Stuart J. Mickel; Gottfried Sedelmeier; Daniel Niederer; Friedrich Schuerch; Manuela Seger; Klaus Schreiner; Robert Daeffler; Adnan Osmani; Dominique Bixel; Olivier Loiseleur; Jacques Cercus; Hans Stettler; and Karl Schaer; Remo Gamboni; Andrew Bach; Guang-Pei Chen; Weichun Chen; Peng Geng; George T. Lee; Eric Loeser; Joseph McKenna; Frederick Ray Kinder; Kurt Königsberger; Kapa Prasad; Timothy Michael Ramsey; Noela Reel; Oljan Repic; Larry Rogers; Wen-Chung Shieh; Run-Ming Wang

Organic Process Research & Development | 2003

A practical synthesis of 6-[2-(2,5-dimethoxyphenyl)ethyl]-4-ethylquinazoline and the art of removing palladium from the products of Pd-catalyzed reactions

Kurt Königsberger; Guang-Pei Chen; Raeann Wu; Michael J. Girgis; Kapa Prasad; Oljan Repic; Thomas J. Blacklock

Tetrahedron Letters | 2006

Deprotection of N-tosylated indoles and related structures using cesium carbonate

Joginder S. Bajwa; Guang-Pei Chen; Kapa Prasad; Oljan Repic; Thomas J. Blacklock

Archive | 2003

Process for the manufacture of organic compounds

Guang-Pei Chen; Prasad Koteswara Kapa; Eric Loeser; Ulrich Beutler; Werner Zaugg; Michael J. Girgis

Organic Process Research & Development | 2007

A Concise Synthesis of a Novel Insulin-Like Growth Factor I Receptor (IGF-IR) Inhibitor†

Joel Slade; Joginder S. Bajwa; Hui Liu; David John Parker; James Vivelo; Guang-Pei Chen; John Vincent Calienni; Edwin Bernard Villhauer; Kapa Prasad; Oljan Repic; Thomas J. Blacklock

Organic Process Research & Development | 2006

A practical enantioselective synthesis of a novel peptide deformylase inhibitor

Joel Slade; David John Parker; Michael J. Girgis; Martin Mueller; James Vivelo; Hui Liu; Joginder S. Bajwa; Guang-Pei Chen; Joseph Carosi; Paul Lee; Apurva Chaudhary; Dana Wambser; Kapa Prasad; Kathryn Rene Bracken; Karl Dean; Helmut Boehnke; Oljan Repic; Thomas J. Blacklock

Organic Process Research & Development | 2007