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Featured researches published by Guanghuan Wang.


Medical Science Monitor | 2015

Altered Levels of Zinc and N-methyl-D-aspartic Acid Receptor Underlying Multiple Organ Dysfunctions After Severe Trauma

Guanghuan Wang; Xiaojun Yu; Dian Wang; Xiaohu Xu; Guang Chen; Xuewu Jiang

Background Severe trauma can cause secondary multiple organ dysfunction syndrome (MODS) and death. Oxidative stress and/or excitatory neurotoxicity are considered as the final common pathway in nerve cell injuries. Zinc is the cofactor of the redox enzyme, and the effect of the excitatory neurotoxicity is related to N-methyl-D-aspartic acid receptor (NMDAR). Material/Methods We investigated the levels of zinc and brainstem NMDAR in a rabbit model of severe trauma. Zinc and serum biochemical profiles were determined. Immunohistochemistry was used to detect brainstem N-methyl-D-aspartic acid receptor 1 (NR1), N-methyl-D-aspartic acid receptor 2A (NR2A), and N-methyl-D-aspartic acid receptor 2B (NR2B) expression. Results Brain and brainstem Zn levels increased at 12 h, but serum Zn decreased dramatically after the trauma. NR1 in the brainstem dorsal regions increased at 6 h after injury and then decreased. NR2A in the dorsal regions decreased to a plateau at 12 h after trauma. The levels of NR2B were lowest in the death group in the brainstem. Serum zinc was positively correlated with NR2A and 2B and negatively correlated with zinc in the brain. Correlations were also found between the brainstem NR2A and that of the dorsal brainstem, as well as between brainstem NR2A and changes in NR2B. There was a negative correlation between zinc and NR2A. Conclusions Severe trauma led to an acute reduction of zinc enhancing oxidative stress and the changes of NMDAR causing the neurotoxicity of the nerve cells. This may be a mechanism for the occurrence of MODS or death after trauma.


Chirurgie De La Main | 2013

Primary giant congenital infantile fibrosarcoma of the left forearm

Shouxing Duan; Xuan Zhang; Guanghuan Wang; Jun Zhong; Z. Yang; Xuewu Jiang; Jianhong Li

Infantile fibrosarcoma is a rare soft tissue tumor in the infant, and only a few cases have been reported as congenital. We report a case of congenital infantile fibrosarcoma of the left forearm at birth. An amputation was performed because the tumor was relapsed soon after surgical removal, and associated with anabrosis and bleeding.


Urologia Internationalis | 2018

Children with Cryptorchidism Complicated by Testicular Torsion: A Case Series

Tao Deng; Xuan Zhang; Guanghuan Wang; Shouxing Duan; Maxian Fu; Jun Zhong; Jianhong Li; Xuewu Jiang

Objective: To investigate the clinical features, diagnosis, treatment and prognosis of children with cryptorchidism complicated by testicular torsion. Methods: The clinical data of 6 children with cryptorchidism complicated by testicular torsion admitted to our hospital from December 2000 to December 2016 were analyzed retrospectively. Results: All 6 children were diagnosed with cryptorchidism by surgery, their age was from 12 days up to 11 years, and the average time between onset of symptoms and diagnosis was 20.5 h. Torsion testis was located in the groin area and the rate of left to right was about 2:1. Twist was 600° on average. All children were admitted because of the inconsolable cry, abdominal pain, and the swelling of the groin. Three patients underwent orchidectomy, while the other 3 patients underwent detorsion and cryptorchidopexy. Color Doppler ultrasound examination showed normal testes at 6 months after operation. Only 1 case was diagnosed with cryptorchidism after birth. Conclusions: Cryptorchidism is an emergency in pediatric urology and often leads to a low testicular salvage rate, especially in infants, due to lack of knowledge, delayed diagnosis, and late treatment. Neonatal genital examination is important for the early diagnosis and management of cryptorchidism.


Medicine | 2017

Diagnosis and treatment of pediatric benign pneumoperitoneum: A case report series of 9 patients

Shouxing Duan; Zong-Bo Sun; Guanghuan Wang; Jun Zhong; Wen-Hui Ou; Maxian Fu; Fusheng Wang; Shu-Hua Ma; Jianhong Li

Introduction: Benign pneumoperitoneum (BPPT) is defined as asymptomatic free intraabdominal air or as pneumoperitoneum without peritonitis. Symptomatic free air requires surgical anagement, but management of asymptomatic pneumoperitoneum is controversial. In this study, we investigate the diagnosis and treatment of BPPT in children. Clinical Findings: The clinical data of 9 pediatric patients with BPPT who were admitted to our hospital from January 2000 to January 2015 were retrospectively analyzed to summarize the diagnosis and treatment. Overall, 9 cases were included with 8 males and 1 female, aged from 4 days to 4 years. Among them there were 6 newborns (including 1 premature infant). Patients were all admitted to hospital with the major clinical symptom of abdominal distension, including 2 cases accompanied by tachypnea, 2 cases with vomiting, 1 case with diarrhea, and 2 cases with fever. No previous constipation or obstructive defecation existed. Six newborns had meconium defecation within 24 hours after birth. Physical examination revealed all patients with relaxed abdominal wall except 1 patient with abdominal distension had slight muscle stiffness and hyperactive bowel sounds. Abdominal X-ray suggested free air under the diaphragm in all cases. Interventions/Outcomes: All patients except for one case of laparotomy were conservatively treated and cured with fasting, infection prevention, rehydration, abdominocentesis, and close observation. Nine cases of patients were all discharged with no death occurrence. After discharge follow-up of 7 months to 6 years was conducted. There was no recurrence of similar symptoms, and children were in good growth and development. Conclusion: The diagnosis of BPPT mainly relies on clinical symptoms in patient, careful abdominal examination, abdominal X-ray combined with abdominocentesis, and the exclusion of gastrointestinal perforation for confirmation. Conservative treatment can cure the disease. Attention should be paid to distinguish with surgical pneumoperitoneum to avoid unnecessary surgical exploration.


Biological Trace Element Research | 2012

Altered levels of trace elements in acute lung injury after severe trauma.

Guanghuan Wang; Xiaoping Lai; Xiaojun Yu; Dian Wang; Xiaohu Xu


Biological Trace Element Research | 2013

Prognostic Value of Blood Zinc, Iron, and Copper Levels in Critically Ill Children with Pediatric Risk of Mortality Score III

Guanghuan Wang; Xueyong Feng; Xiaojun Yu; Xiaohu Xu; Dian Wang; Hanjin Yang; Xuezhi Shi


Biological Trace Element Research | 2015

Blood Zinc, Iron, and Copper Levels in Critically Ill Neonates

Guanghuan Wang; Dian Wang; Xuewu Jiang; Xiaojun Yu; Lian Ma; Jun Zhong; Xueyong Feng


International Journal of Clinical and Experimental Medicine | 2015

Computer-aided three-dimensional reconstruction of main vessels in hemangiomas

Guanghuan Wang; Jun Zhong; Jianhong Li; Xuan Zhang; Shouxing Duan; Maxian Fu; Fusheng Wang; Xuewu Jiang


Medicine | 2018

Changes of serum trace elements in early stage trauma and its correlation with injury severity score

Kaihong Chen; Junyao Lv; Guanghuan Wang; Xiaojun Yu; Xiaohu Xu; Guanghui Zhu; Zhuying Shao; Dian Wang; Chang Tang; Shanqing Cai


Medicine | 2017

Peutz–Jeghers syndrome with intermittent upper intestinal obstruction: A case report and review of the literature

Shouxing Duan; Guanghuan Wang; Jun Zhong; Wen-Hui Ou; Maxian Fu; Fusheng Wang; Shu-Hua Ma; Jianhong Li

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