Guenter Knaup

O-Acetyl-L-homoserine: A versatile synthon for the synthesis of L-homoserine peptides and 3-amino-2-pyrrolidinones

Although L-homoserine is a naturally occurring amino acid with important biological properties, only few examples of homoseryl peptides are known, which have been mainly prepared by using either the benzyl [1,2] or the trityl [3,4] group for the O-protection. Furthermore, homoserine amides are potential precursors for the introduction of a ring, which can act as conformational constraints in peptides and peptidomimetics [5-7]. Herein, we report new methods for the preparation of homoserine amides and their conversion into