Guillaume Haiat

Bone quantitative ultrasound

1 Bone Overview, Pr. David Mitton, Pr. Christian Roux, Dr. Pascal Laugier 2 Introduction to the physics of ultrasound, Dr. Pascal Laugier, Dr. Guillaume Haiat.- 3 Quantitative ultrasound instrumentation for bone in vivo characterization, Dr. Pascal Laugier.- 4 Clinical applications, Dr. Reinhard Barkmann, Pr. C-C Gluer.- 5 Poromechanical Models: Biots theory - Modified Biots theory - Multilayer model, Dr. Michal Pakula, Pr. Mariusz Kaczmarek,Dr. Frederic Padilla.- 6 Scattering by trabecular bone, Dr. Frederic Padilla, Dr. Keith Wear.- 7 Guided waves in cortical bone, Dr. Maryline Talmant, Josquin Foiret,Dr. Jean-Gabriel Minonzio.- 8 Numerical methods for ultrasonic bone characterization, Dr. Emanuel Bossy, Dr. Quentin GRIMAL.- 9 Homogenization theories and inverse problems, Prof. Robert P. Gilbert, Dr. Ana Vasilic, Dr. Sandra Ilic.- 10 Linear acoustics of trabecular bone, Prof. Jukka S Jurvelin et al..- 11 The Fast and Slow Wave Propagation in Cancellous Bone -Experiments and Simulations, Prof. Atsushi Hosokawa, Dr. Yoshiki Nagatani, Prof. Mami Matsukawa.- 12 Phase Velocity of Cancellous Bone Negative dispersion arising from fast and slow waves, interference, diffraction, and phase cancellation at piezoelectric receiving elements, Prof. James G. Miller et al..- 13 Linear ultrasonic properties of cortical bone: in vitro studies, Dr. Guillaume Haiat.- 14 Ultrasonic monitoring of fracture healing, Dr. Vasilios Protopappas, Dr. Maria G. Vavva, Dr. Konstantinos N. Malizos, Prof. Dimitrios I. Fotiadis.- 15 Nonlinear acoustics for non-invasive assessment of bone micro-damage, Dr. Marie Muller, Dr. Guillaume Renaud.- 16 Microscopic elastic properties, Prof. Kay Raum.- 17 Ultrasonic Computed Tomography, Dr. Philippe Lasaygues.- Index.

Variation of Ultrasonic Parameters With Microstructure and Material Properties of Trabecular Bone: A 3D Model Simulation†‡

This study determined the influence of trabecular bone microstructure and material properties on QUS parameters using numerical simulations coupled with high‐resolution synchrotron radiation μCT.

Fast wave ultrasonic propagation in trabecular bone: Numerical study of the influence of porosity and structural anisotropy

Our goal is to assess the potential of computational methods as an alternative to analytical models to predict the two longitudinal wave modes observed in cancellous bone and predicted by the Biot theory. A three-dimensional (3D) finite-difference time-domain method is coupled with 34 human femoral trabecular microstructures measured using microcomputed tomography. The main trabecular alignment (MTA) and the degree of anisotropy (DA) were assessed for all samples. DA values were comprised between 1.02 and 1.9. The influence of bone volume fraction (BV/TV) between 5% and 25% on the properties of the fast and slow waves was studied using a dedicated image processing algorithm to modify the initial 3D microstructures. A heuristic method was devised to determine when both wave modes are time separated. The simulations (performed in three perpendicular directions) predicted that both waves generally overlap in time for a direction of propagation perpendicular to the MTA. When these directions are parallel, both waves are separated in time for samples with high DA and BV/TV values. A relationship was found between the least bone volume fraction required for the observation of nonoverlapping waves and the degree of anisotropy: The higher the DA, the lower the least BV/TV.

Determination of the heterogeneous anisotropic elastic properties of human femoral bone: From nanoscopic to organ scale

Cortical bone is a multiscale composite material. Its elastic properties are anisotropic and heterogeneous across its cross-section, due to endosteal bone resorption which might affect bone strength. The aim of this paper was to describe a homogenization method leading to the estimation of the variation of the elastic coefficients across the bone cross-section and along the bone longitudinal axis. The method uses the spatial variations of bone porosity and of the degree of mineralization of the bone matrix (DMB) obtained from the analysis of 3-D synchrotron micro-computed tomography images. For all three scales considered (the foam (100 nm), the ultrastructure (5 microm) and the mesoscale (500 microm)), the elastic coefficients were determined using the Eshelbys inclusion problem. DMB values were used at the scale of the foam. Collagen was introduced at the scale of the ultrastructure and bone porosity was introduced at the mesoscale. The pores were considered as parallel cylinders oriented along the bone axis. Each elastic coefficient was computed for different regions of interest, allowing an estimation of its variations across the bone cross-section and along the bone longitudinal axis. The method was applied to a human femoral neck bone specimen, which is a site of osteoporotic fracture. The computed elastic coefficients for cortical bone were in good agreement with experimental results, but some discrepancies were obtained in the endosteal part (trabecular bone). These results highlight the importance of accounting for the heterogeneity of cortical bone properties across bone cross-section and along bone longitudinal axis.

The adhesive contact of viscoelastic spheres

Abstract We have formulated the restricted self-consistent model for the adhesive contact of linear viscoelastic spheres. This model is a generalization of both the Ting (J. Appl. Mech. 33 (1966) 845) approach to the viscoelastic contact of adhesionless spheres and the restricted self-consistent model for adhesive axisymmetric bodies. We also show how the model can be used in practice by giving a few examples of numerical solutions.

Effects of frequency-dependent attenuation and velocity dispersion on in vitro ultrasound velocity measurements in intact human femur specimens

Numerous studies have shown that ultrasonic velocity measured in bone provides a good assessment of osteoporotic fracture risk. However, a lack of standardization of signal processing techniques used to compute the speed of sound (SOS) complicates the comparison between data obtained with different commercial devices. In this study, 38 intact femurs were tested using a through-transmission technique and SOS determined using different techniques. The resulting difference in measured SOS was determined as functions of the attenuation and the velocity dispersion. A numerical simulation was used to explain how attenuation and dispersion impact two different SOS measurements (group velocity, velocity based on the first zero crossing of the signal). A new method aimed at compensating for attenuation was devised and led to a significant reduction in the difference between SOS obtained with both signal processing techniques. A comparison between SOS and X-ray density measurements indicated that the best correlation was reached for SOS based on the first zero crossing apparently because it used a marker located in the early part of the signal and was less sensitive to multipath interference. The conclusion is that first zero crossing velocity may be preferred to group velocity for ultrasonic assessment at this potential fracture site.

Biomechanical determinants of the stability of dental implants: Influence of the bone–implant interface properties

Dental implants are now widely used for the replacement of missing teeth in fully or partially edentulous patients and for cranial reconstructions. However, risks of failure, which may have dramatic consequences, are still experienced and remain difficult to anticipate. The stability of biomaterials inserted in bone tissue depends on multiscale phenomena of biomechanical (bone-implant interlocking) and of biological (mechanotransduction) natures. The objective of this review is to provide an overview of the biomechanical behavior of the bone-dental implant interface as a function of its environment by considering in silico, ex vivo and in vivo studies including animal models as well as clinical studies. The biomechanical determinants of osseointegration phenomena are related to bone remodeling in the vicinity of the implants (adaptation of the bone structure to accommodate the presence of a biomaterial). Aspects related to the description of the interface and to its space-time multiscale nature will first be reviewed. Then, the various approaches used in the literature to measure implant stability and the bone-implant interface properties in vitro and in vivo will be described. Quantitative ultrasound methods are promising because they are cheap, non invasive and because of their lower spatial resolution around the implant compared to other biomechanical approaches.

Relationship between ultrasonic parameters and apparent trabecular bone elastic modulus: a numerical approach.

The physical principles underlying quantitative ultrasound (QUS) measurements in trabecular bone are not fully understood. The translation of QUS results into bone strength remains elusive. However, ultrasound being mechanical waves, it is likely to assess apparent bone elasticity. The aim of this study is to derive the sensitivity of QUS parameters to variations of apparent bone elasticity, a surrogate for strength. The geometry of 34 human trabecular bone samples cut in the great trochanter was reconstructed using 3-D synchrotron micro-computed tomography. Finite-difference time-domain simulations coupled to 3-D micro-structural models were performed in the three perpendicular directions for each sample and each direction. A voxel-based micro-finite element linear analysis was employed to compute the apparent Youngs modulus (E) of each sample for each direction. For the antero-posterior direction, the predictive power of speed of sound and normalized broadband ultrasonic attenuation to assess E was equal to 0.9 and 0.87, respectively, which is better than what is obtained using bone density alone or coupled with micro-architectural parameters and of the same order of what can be achieved with the fabric tensor approach. When the direction of testing is parallel to the main trabecular orientation, the predictive power of QUS parameters decreases and the fabric tensor approach always gives the best results. This decrease can be explained by the presence of two longitudinal wave modes. Our results, which were obtained using two distinct simulation tools applied on the same set of samples, highlight the potential of QUS techniques to assess bone strength.

Influence of a gradient of material properties on ultrasonic wave propagation in cortical bone: Application to axial transmission

The aim of this work is to evaluate the effect of a spatial gradient of material properties (mass density and stiffness coefficients) of cortical bone on its ultrasonic response obtained with an axial transmission device. Therefore, a two-dimensional finite element time-domain method is derived to model transient wave propagation in a three-layer medium composed of an inhomogeneous transverse isotropic solid layer sandwiched between two acoustic fluid layers and excited by an acoustic linear source located in one fluid layer, delivering broadband ultrasonic pulses. The model couples the acoustic propagation in both fluid media with the elastodynamic response of the solid layer. A constant spatial gradient of material properties is considered for two values of bone thicknesses corresponding to relatively thick and thin bone widths. For a thin bone (0.6 mm) compared to wavelength (around 4 mm at 1 MHz), the results are in good agreement with a S(0) Lamb wave assuming a homogeneous material with spatially averaged material properties. For a thick bone (4 mm), the results are in agreement with the propagation of a lateral wave and allow the derivation of an equivalent contributing depth in the case of a transverse isotropic inhomogeneous solid layer.

Effects of Biomechanical Properties of the Bone–Implant Interface on Dental Implant Stability: From In Silico Approaches to the Patient's Mouth

Dental implants have become a routinely used technique in dentistry for replacing teeth. However, risks of failure are still experienced and remain difficult to anticipate. Multiscale phenomena occurring around the implant interface determine the implant outcome. The aim of this review is to provide an understanding of the biomechanical behavior of the interface between a dental implant and the region of bone adjacent to it (the bone-implant interface) as a function of the interfaces environment. First, we describe the determinants of implant stability in relation to the different multiscale simulation approaches used to model the evolution of the bone-implant interface. Then, we review the various aspects of osseointegration in relation to implant stability. Next, we describe the different approaches used in the literature to measure implant stability in vitro and in vivo. Last, we review various factors affecting the evolution of the bone-implant interface properties.