Guizhen Dong
Princeton University
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Publication
Featured researches published by Guizhen Dong.
Bioorganic & Medicinal Chemistry Letters | 2011
Seong Heon Kim; Gopinadhan N. Anilkumar; Lisa Guise Zawacki; Qingbei Zeng; De-Yi Yang; Yuefei Shao; Guizhen Dong; Xiaolian Xu; Wensheng Yu; Yueheng Jiang; Chung-Her Jenh; James W. Hall; Carolyn DiIanni Carroll; Doug W. Hobbs; John J. Baldwin; Brian F. Mcguinness; Stuart B. Rosenblum; Joseph A. Kozlowski; Bandarpalle B. Shankar; Neng-Yang Shih
The SAR of a novel pyrazinyl-piperazinyl-piperidine scaffold with CXCR3 receptor antagonist activity was explored. Optimization of the DMPK profile and reduction of hERG inhibition is described. Compound 16e with single-digit CXCR3 affinity, good rat PK and hERG profiles has been identified as a lead for further study.
Bioorganic & Medicinal Chemistry Letters | 2009
Brian F. Mcguinness; Carolyn DiIanni Carroll; Lisa Guise Zawacki; Guizhen Dong; Cangming Yang; Doug W. Hobbs; Biji Jacob-Samuel; James W. Hall; Chung-Her Jenh; Joseph A. Kozlowski; Gopinadhan N. Anilkumar; Stuart B. Rosenblum
High-throughput screening of an encoded combinatorial aryl piperazine library led to the identification of a novel series of potent piperazinyl-piperidine based CXCR3 antagonists. Analogs of the initial hit were synthesized via solid and solution phase methods to probe the influence of structure on the CXCR3 binding of these molecules. Various functional groups were found to contribute to the overall potency and essential molecular features were identified.
Bioorganic & Medicinal Chemistry Letters | 2010
Brian F. Mcguinness; Andrew G. Cole; Guizhen Dong; Marc-Raleigh Brescia; Yuefei Shao; Ian R. Henderson; Laura L. Rokosz; Tara M. Stauffer; Neelima Mannava; Earl F. Kimble; Catherine M. Hicks; Nicole S. White; Pamela Wines; Elizabeth Quadros
A novel series of adenosine A(2A) receptor antagonists was identified by high-throughput screening of an encoded combinatorial compound collection. The initial hits were optimized for A(2A) binding affinity, A(1) selectivity, and in vitro microsomal stability generating orally available 2-aminoimidazo[4,5-b]pyridine-based A(2A) antagonist leads.
Bioorganic & Medicinal Chemistry Letters | 2004
Tao Guo; Anton Egbert Peter Adang; Roland E. Dolle; Guizhen Dong; Dan Fitzpatrick; Peng Geng; Koc-Kan Ho; Steven G. Kultgen; Ruiyan Liu; Edward Mcdonald; Brian F. Mcguinness; Kurt W. Saionz; Kenneth J. Valenzano; Nicole van Straten; Dan Xie; Maria L. Webb
Bioorganic & Medicinal Chemistry Letters | 2004
Tao Guo; Anton Egbert Peter Adang; Guizhen Dong; Dan Fitzpatrick; Peng Geng; Koc-Kan Ho; Charles H. Jibilian; Steven G. Kultgen; Ruiyan Liu; Edward Mcdonald; Kurt W. Saionz; Kenneth J. Valenzano; Nicole van Straten; Dan Xie; Maria L. Webb
Bioorganic & Medicinal Chemistry Letters | 2011
Yuefei Shao; Gopinadhan N. Anilkumar; Carolyn DiIanni Carroll; Guizhen Dong; James W. Hall; Doug W. Hobbs; Yueheng Jiang; Chung-Her Jenh; Seong Heon Kim; Joseph A. Kozlowski; Brian F. Mcguinness; Stuart B. Rosenblum; Inna Schulman; Neng-Yang Shih; Youheng Shu; Michael K.C. Wong; Wensheng Yu; Lisa Guise Zawacki; Qingbei Zeng
Bioorganic & Medicinal Chemistry Letters | 2004
Koc-Kan Ho; Kenneth C. Appell; John J. Baldwin; Adolph C. Bohnstedt; Guizhen Dong; Tao Guo; Robert A. Horlick; Khondaker R. Islam; Steven G. Kultgen; Christopher M. Masterson; Edward Mcdonald; Kirk McMillan; J.Richard Morphy; Zoran Rankovic; Hardy Sundaram; Maria L. Webb
Archive | 2002
Tao Guo; Koc-Kan Ho; Edward Mcdonald; Roland E. Dolle; Kurt W. Saionz; Steven G. Kultgen; Ruiyan Liu; Guizhen Dong; Peng Geng; Anton Egbert Peter Adang; Straten Nicole Corine Renee Van
Archive | 2006
Andrew G. Cole; Brian F. Mcguinness; Marc-Raleigh Brescia; Yuefei Shao; Guizhen Dong; Ian Henderson
Archive | 2010
Brian F. Mcguinness; Koc-Kan Ho; Suresh Babu; Guizhen Dong; Jingqi Duo; Thuy X. H. Le; Kurt W. Saionz