Gulcin Basdemir

Clear cell chondrosarcoma: unusual radiologic appearances with histologic correlation

Abstract. Clear cell chondrosarcoma is a rare variant of the bone tumors with distinct radiologic and pathologic features. In this report two cases of clear cell chondrosarcomas with atypical radiologic appearances are presented. The findings of X-ray films and MRI are described with histologic correlation. In the first case the lesion showed a very expansile and long segment involvement of the humerus. In the second case the lesion was located in the diaphysis of the femur causing a large cortical destruction.

Actinomycosis osteomyelitis of the jaws: Report of four cases and a review of the literature

Actinomycosis osteomyelitis of the jaw bones, particularly in the maxilla, is an extremely rare disease. This report presents two cases of maxillary and two cases of mandibular actinomycosis osteomyelitis, with the diagnosis particularly based on histological procedures. The highly diversified pathogenicity of the phenomenon and the absence of solid diagnostic criteria are discussed. Laboratory challenges are emphasized, and a comprehensive overview of the entity including treatment alternatives is given along with a review of the relevant literature.

Cystic bone lesions: histopathological spectrum and diagnostic challenges.

Abstract Objective: Bone cysts are benign lesions occurring in any bone, regardless of age. They are often asymptomatic but may cause pain, swelling, fractures, and local recurrence and may be confused with other bone lesions. Material and Method: We retrospectively re-evaluated 143 patients diagnosed with aneurysmal bone cyst (n=98, 68.5%), solitary bone cysts (n=17 11.9%), pseudocyst (n=10.7%), intraosseous ganglion (n=3, 2.1%), hydatid cyst (n=2; 1.4), epidermoid cyst (n=1, 0.7%) and cysts demonstrating “mixed” aneurysmal-solitary bone cyst histology (n=12, 8.4%), and compared them with nonparametric tests. Results: Aneurysmal bone cyst, solitary bone cysts and mixed cysts were frequently seen in the first two decades of life while the others occurred after the fourth decade. Aneurysmal bone cysts, intraosseous ganglion and pseudocysts were more common in women contrary to solitary bone cyst and mixed cysts (the female/male ratio was 1.22, 2 and 1.5 versus 0.7 and 0.5, respectively). Aneurysmal bone cyst, solitary bone cysts and “mixed” cysts were mostly seen in long bones, predominantly the femur, while epidermoid, hydatid and pseudocysts were all seen in flat bones like the vertebra, pelvis and mandible (p=0.001, chi-square). Repeat biopsies were performed in 19 cases (13.3%), 84.2% of which were aneurysmal bone cyst (5 conventional, 9 solid, 1 secondary and 1 subperiosteal) and three (15.8%) were mixed cysts (p=0.02, chi-square). Notably, some of them were located in inaccessible areas of pelvis (n=3), femur (n=3) and maxilla (n=2). Conclusion: The most common and challenging intraosseous cysts are aneurysmal bone cysts, particularly the “solid” variant. The “mixed” aneurysmal-solitary bone cyst “subgroup” requires further research with larger series to be defined more thoroughly. Öz Amaç: Kemik kistleri, her yaşta ve kemikte gorulebilen benign lezyonlardır. Sıklıkla asemptomatiktirler, ancak ağrı, şişlik, kırık ve lokal nuks yapabilir, diğer kemik lezyonlarıyla karıştırılabilirler. Gereç ve Yöntem: Calışmamızda 98’i (%68,5) anevrizmal kemik kisti; 17’si (%11,9) soliter kemik kisti; 12’si (%8,4) “mikst” anevrizmal kemik kisti-soliter kemik kisti histolojisi gosteren; 10’u (%7) psodokist, 3’u (%2,1) intraosseoz ganglion, 2’si (%1,4) kist hidatik, 1’i (%0,7) epidermoid kisti tanısı almış; toplam 143 olgu geriye donuk olarak değerlendirilmiş, klinikopatolojik veriler nonparametrik testlerle karşılaştırılmış, bulgular histopatolojik tanı guclukleri acısından tartışılmıştır. Bulgular: Anevrizmal kemik kisti, soliter kemik kisti ve mikst kistler ilk iki dekatta; diğerleri dorduncu dekaddan sonra gorulmektedir. Anevrizmal kemik kisti, intraosseoz ganglion ve psodokistler kadınlarda; soliter kemik kisti ve mikst kistler ise erkeklerde daha sık gorulmektedir (Kadın/erkek oranı sırasıyla 1,22; 2 ve 1,5’a karşı 0,7 ve 0,5’dir) Anevrizmal kemik kisti, soliter kemik kisti ve mikst kist; femur başta olmak uzere en sık uzun kemikleri tutarken (sırasıyla %24,5, %47, %33,4;epidermoid kist, kist hidatik ve psodokistler tum olgularda vertebra, pelvis, mandibula gibi yassı kemikleri secmektedir (p=0,001, ki-kare). Biyopsi tekrarı yapılan 19 olgunun (%13,3); %84,2’si anevrizmal kemik kisti (5 konvansiyonel, 9 solid, 1 sekonder, 1 subperiosteal); 3’u (%15,8) ”mikst kist” dir (p=0,02, ki-kare). Bu olguların bir kısmının pelvis (n=3), femur (n=3), maksillada (n=2) zor ulaşılan alanlarda yerleştiği dikkati cekmiştir. Sonuç: İntraosseoz kistler icerisinde en sık gorulen, aynı zamanda en cok ayırıcı tanı gucluğu yaratan lezyon solid varyantı başta olmak uzere anevrizmal kemik kistidir. Mikst anevrizmal kemik kisti-soliter kemik kisti olgu grubu iyi tanımlanmamış bir grup olup daha geniş serilerle araştırılmalıdır.

Coexistante of intraocular eyelashes and anterior chamber cyst after penetrating eye injury: a case presentation

We herein describe a patient in whom two intraocular eyelashes and an anterior chamber cyst embedded into the anterior surface of the iris was detected following penetrating eye injury. After a one year asymptomatic period, the patient was hospitalized because of uveitic reaction in the anterior chamber which may be due to cyst development. The lashes and cyst were removed surgically, and examined pathologically. There was no complication in one year follow-up period.

Treatment results of osteosarcoma of the extremity in children and adolescents at Ege University Hospital.

Twenty-five patients were treated for osteosarcoma of the extremity at Ege University Hospital. Eight of them were metastatic. All patients received cisplatin, doxorubicin, ifosfamide, and methotrexate preoperatively. Twenty-three patients underwent surgery at around week 15 (11-18 weeks). All but one underwent limb-sparing surgery. While good responders continued to receive the same drugs, poor responders were given the same regimen before 1996, but high-dose ifosfamide alone after 1996. For all patients the projected event-free survival (EFS) rates were 63.5% at 2 years and 53% at 5 years. The projected overall survival (OS) rates were 72% at 2 years and 62% at 5 years. For nonmetastatic patients, 5-year EFS and OS rates were 67% as compared with metastatic patients (25 and 50%)( p = .01 for EFS; p > .05 for OS). The results show that nonmetastatic patients with osteosarcoma of the extremity have favorable prognosis on this therapy regimen, allowing a high rate of limb-sparing surgery.