Gülden Kafalı

Effect of Antiepileptic Drugs on Bone Mineral Density in Children Between Ages 6 and 2 Years

We assessed the effects of sodium valproate and carbamazepine monotherapy on bone mineral density (BMD) in children. BMD at the lumbar vertebrae (L1-L4) and radius-ulna was measured by the dual-energy x-ray absorptiometry (DEXA) method in 19 children (9 girls, 10 boys) with uncomplicated epilepsy and in 57 healthy children (28 girls, 29 boys), between the ages of 6 and 12 years. The study patients had been receiving either sodium valproate (n=13) or carbamazepine (n=6) monotherapy for more than 6 months. There were no significant differences between the control and study patients in age, height, weight, physical activity, or of serum concentrations of calcium, phosphate, and transaminases (aspartate aminotransferase, alanine aminotransferase). However, the serum alkaline phosphatase concentration was greater in the patient group as compared with the control group. BMD values were lower in girl patients (L1-L4; 0.497 0.08 vs 0.566 0.07 g/cm2, p<0.05), but not in boys (0.534 0.06 vs 0.530 0.08 g/cm2). While BMD reduction was 8% in valproate therapy (midregion of radius-ulna; 0.287.03 vs 0.312 04 g/cm2, p<0.04), it was reduced only 4.5% in the carbamazepine-treated group (0.298 01 vs 0.312 04 g/cm2, statistically not significant), although the mean durations of monotherapy with valproate (1.8 7 years) and carbamazepine (1.7 8 years) were similar. Thus decreased bone mineralization was observed in children with epilepsy, treated with sodium valproate even though treatment was for a rather short time.

A new syndrome with cardiac malformation, cleft lip-palate, microcephaly and digital anomalies ?

A family with cardiac malformation, cleft lip‐palate, short stature, microcephaly, distally placed thumbs, short 2nd and 5th fingers, long and broad 1st toes, broad distance between 1st and 2nd toes and mediodorsal curvature of the 4th toes with syndactyly of the 2nd and 3rd toes has been described as having a new syndrome. While some members of the family had full signs of the syndrome, others had similar but fewer and less severe anomalies of the same structures. The presence of common findings in three generations, its variable expressivity and pleiotropism, and the non‐consanguineous history in the parents suggest that the inheritance is autosomal dominant.

Sivas il merkezinde kreş ve anaokullarında sekretuvar otitis media prevalansı

Bu calismada sekretuvar otitis media prevalansini ve ilgili risk faktorlerini belirlemeyi amacladik Sivas ta kres ve anaokullarinda 2 6 yas arasi 606 cocukta sekretuvar otitis media prevalansi arastirildi Sekretuvar otitis media tanisi otoskopik muayene ve timpanometri ile konuldu Ortalama prevalansi 18 8 olarak bulundu Daha once ve son bir yilda orta kulak iltihabi oykusu sik ust solunum yolu enfeksiyonu oykusu ailede kulak iltihabi ve allerjik hastalik oykusu kalabalik aile odasini birden fazla kisi ile paylasma dusuk dogum agirlikli dogma yetersiz anne sutu alma lt;5 ay ile sekretuvar otitis media arasi anlamli bir iliski bulundu Sekretuvar otitis media sikligi 2 yasta en yuksek iken 5 yasta ikinci bir pik goruldu Cinsiyet ve sigara ile sekretuvar otitis media arasi anlamli bir iliski saptanmamakla birlikte sigaraya maruz kalan cocuklarda sekretuvar otitis media sikligi daha yuksekti Sekretuvar otitis mediaya bagli isitme kayipli cocuklarin 63 unun ailelerince 89 unun ogretmenlerince fark edilmedigi saptandi Sekretuvar otitis media tespit edilen cocuklarin okul basarilarinin dusuk oyun ders ve aktivitelere ilgilerinin az oldugu bulundu Anahtar kelimeler: Sekretuvar otitis media prevalans risk faktorleri

Yenidoğan Döneminde Hematolojik Bulgularla Ortaya Çıkan Bir Fanconi Anemisi Olgusu

Familial hemophagocytic lymphohistiocytosis was diagnosed in a three and a half month old infant with anemia hepatosplenomegaly and intractable fever Three siblings had died due to unknown causes The diagnosis was verified with autopsy Clinical and laboratory findings of the case are discussed in the light of literature Key words: Familial Hemophagocytic Lymphohistiocytosis

Bir Aglossi Adaktili Sendromu Olgusu Anal Darlıkla Birlikte

The syndrome of aglossia adactylia is an uncommon syndrome characterized by micrognathia hypoglossia or aglossia and absence of one or more of the extremities The patient was admitted with the complaints of lack of right hand and distal left leg below the knee In addition to these findings physical examination revealed mild micrognathia and hypoglossia large and low set ears telecantus high palate and anal stenosis Anal atresia is uncommon with this syndrome for that reason we have presented this case of Hanhart s syndrome with anal stenosis Key words: Aglossia Adactylia

Sivas Yöresinde Preterm Bebeklerde Peri İntraventriküler Kanama

The aim of this study was to determine the prevalence of peri intraventricular hemorrhage in pretem infants aged between 28 37 gestational weeks in Sivas province The study was carried out on 47 preterm infants in the unit of neonatology of Cumhuriyet University Hospital The mean gestational age of the study group was 34 2±2 4 weeks Birth weights ranged from 600 gr to 2350 gr mean 1443±429 gr Of the 47 preterm infants 44 were evaluated by cranial ultrasonography and 3 were evaluated by cranial computed tomography Perintraventricular hemorrhage was detected in 19 of the 47 infants 40 4 The gestational ages and birth weights of the infants with peri intraventricular hemorrhage were significantly low Respiratory distress syndrome was the statistically significant factor among the neonatal factors in relation to peri intra ventricular hemorrhage The mortality rate of peri intraventricular hemorrhage was 78 9 percent Key words: Peri Intraventricular Hemorrhage Cranial Ultrasonographyx

Bir Lesch Nyhan Sendromu Olgusu

Lesch Nyhan sendromu purin metabolizmasinin X e bagli resesif kalitilan bir bozuklugudur Bozuklugun sebebi hipoksantin guanin fosforibozil transferaz enziminin eksikligidir Hastalikta hiperurisemi selfmutilasyon koreoatetosis spastisite ve mental retardasyon ile karakterizedir Bu yazida mental retardasyonu selfmutilasyonu spastisitesi olan bir Lesch Nyhan sendromu olgusu ve ilgili literatur gozden gecirildi Anahtar kelimeler: Lesch Nyhan Sendromu Selfmutilasyon Purin Metabolizmasi