Gulsen Aydin

Effects of chronic ingestion of sodium fluoride on myocardium in a second generation of rats.

Possible effects of long term exposure (6 months) to sodium fluoride (NaF) through drinking water on the morphology and biochemistry of myocardial tissue in second generation adult male rats were investigated. Wistar strain female and male rats were reared until the second generation of rats obtained, during which they were given 1, 10, 50 and 100 mg/L NaF in drinking water. Of the second generation, 28 male rats were divided into four groups and had the same treatment. All the second generation rats were sacrificed and autopsied at the end of the 6 months. In the samples of myocardial tissues, the levels of serum fluoride and the activities of principal antioxidant enzymes were determined, and a histopathological examination was conducted. Significant histopathological changes were found in the myocardial tissue of rats treated with 50 and 100 mg/L NaF. These were myocardial cell necrosis, extensive cytoplasmic vacuole formation, nucleus dissolution in myosits, swollen and clumped myocardial fibers, fibrillolysis, interstitial oedema, small hemorrhagic areas and hyperaemic vessels. Additionally, the increased activities of superoxide dismutase (SOD), glutathione peroxidase (GSH–Px), catalase (CAT) and thiobarbituric acid–reactive substance (TBARS) levels were observed in the myocardial tissues of rats treated with 10 and 50 mg/L NaF. On the other hand, the activities of SOD, GSH–Px, and CAT decreased, but the TBARS levels increased in the myocardial tissues of rats treated with 100 mg/L. The present results revealed that prolonged ingestion of fluoride through drinking water, particularly with high doses, induced significant histopathological and biochemical changes leading to myocardial tissue damage.

Histopathological Changes of Chorda Tympani in Chronic Otitis Media

Objective To investigate whether histopathological changes of chorda tympani might exist in patients with chronic otitis media without facial paralysis.

Prevention of mobile phone induced skin tissue changes by melatonin in rat: an experimental study:

Most of the mobile phones in Turkey emit 900 MHz radiation which is mainly absorbed by the skin and, to a lesser extent, muscle. The aim of this study was to investigate the effects the 900 MHz electromagnetic irradiation emitted by these devices on the induction of histopathologic changes in skin and the effect of melatonin (Mel) on any of these changes. Thirty male Wistar-Albino rats were used in the study. The experimental groups were composed of: a nontreated control group, an irradiated group (IR) without Mel and an irradiated with Mel treatment group (IR + Mel). 900 MHz radiation was applied to IR group for 10 days (30 min/day). The IR + Mel group received 10 mg/kg per day melatonin in tap water for 10 days before irradiation. At the end of the tenth day, the skin graft was excized from the thoraco-abdominal area. Histopathologic changes in skin were analyzed. In the IR group, increased thickness of stratum corneum, atrophy of epidermis, papillamatosis, basal cell proliferation, increased granular cell layer (hypergranulosis) in epidermis and capillary proliferation, impairment in collagen tissue distribution and separation of collagen bundles in dermis were all observed compared to the control group. Most of these changes, except hypergranulosis, were prevented with melatonin treatment. In conclusion, exposure to 900 MHz radiation emitted by mobile phones caused mild skin changes. Furthermore, melatonin treatment can reduce these changes and may have a beneficial effect to prevent 900 MHz mobile phone-induced rat skin changes.

Investigation of biochemical and histopathological effects of Mentha piperitaLabiatae and Mentha spicata Labiatae on liver tissue in rats

The plant Mentha piperita, or peppermint, is commonly used in the treatment of loss of appetite, common cold, bronchitis, sinusitis, fever, nausea and vomiting, and indigestion as a herbal agent. In this study, we aimed to investigate biochemical and histological effects of M. piperita Labiatae, growing in the Yenisar Bademli town of Isparta city, and Mentha spicata Labiatae, growing in the Anamas high plateau of the Yenisar Bademli town, on the rat liver tissue. Forty-eight male Wistar albino rats weighing 200-250 g were used for this study. Rats were divided into four groups of 12 animals: Group I received no herbal tea (control group); Group II received 20 g/L M. piperita tea; Group III received 20 g/L M. spicata tea; and Group IV received 40 g/L M. spicata tea. Herbal teas were prepared daily and provided at all times to the rats during 30 days as drinking water. Liver function tests, including aspartate aminotransferase (AST/GOT) and alanine aminotransferase (ALT/GPT) activities were measured. To evaluate liver antioxidant defences, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), cata lase (CAT) and thiobarbituric acid reactive substance (TBARS) activities were determined in the homogenates of liver tissue. In addition, liver tissues were submitted for histopathologic examination. AST and ALT activities were increased in Group II, Group III and Group IV gradually when compared with the control group. The difference between Group II and the control group was not statistically significant (P > 0.016). Increases in AST and ALT activities of Group III and Group IV were statistically significant when compared with the control group. SOD, GSH-Px and CAT activities were increased in Group II when compared with the control group but the difference was not statistically significant (P > 0.016). However, SOD, GSH-Px activities and the TBARS level were significantly increased, and CAT activity was significantly decreased in Group III when compared with the control group. In Group IV, while SOD, GSH-Px and CAT activities were decreased, the TBARS level was increased as compared with the control group (P < 0.0016). Histopathological evaluation of experimental groups revealed a mild to severe degree of hepatic damage when compared to the control group. In Group II, there was only minimal hepatocytes degeneration. In Groups III and IV, there were granular or ballooning hepatocyte degeneration and necrosis, sinusoidal and central vein dilatation. It was concluded that lipid peroxidation and hepatic damage occurs after M. piperita and M. spicata administration in rat liver and the damage seems to be dose dependent.

Başlangıç Kliniği Kemik Metastazları Olan Tiroid Karsinomu

SuleymanDemirel Universitesi TIP FAKULTESI DERGISI: 1995 Haziran; 2(2) Baslangic Klinigi Kemik Metastazlari Olan Tiroid Karsinomu M.Numan Tamer Mehmet Isler Harun Dogru Gulsen Aydin M.Kursat Bozkurt Ekmel Tezel Mehmet Bahceci Ozet Palpabl tiroid nodulu olmaksizin uzak metastazlanyla seyreden bir Hurthle celi tiroid karsinomu olgusu sunulmustur. Ozellikle yaygin kemik metastazlari olan hastalarda ayirici tanida tiroid kanseri dusunmenin onemi vurgulanmistir. Anahtar Kelimeler: Tiroid karsinomu, kemik metastazi. Abstract A Thyroid Carcinoma Presenting Initially with Bone Metastases A patient voith Hurthle celi thyroid carcinoma who had distant metastases without any palpable thyroid nodule was presented. in differential diagnosis of patients with widespread bone metastases, probability of thyroid carcinoma must be considered, especially. Key Words: Thyroid carcinoma, bone metastase.

İntrakranial Kavernomalar (Olgu Sunumu)

SuleymanDemirel Universitesi TIP FAKULTESI DERGISI: 1995 Aralik; 2(4) Intrakranial Kavernomalar (Olgu Sunumu) Erdal Kalkan Galip Akhan Hasan R. Koyuncuoglu Gulsen Aydin Haci Kaymaz Aliye Sari Ahmet Dagtekin Ozet Santral sinir sisteminin oldukca nadir gorulen konjenital vaskulcr malformasyonlar grubundan olan kavernomalar; epileptik nobet yakinmasi ile basvuran ve cerrahi olarak tedavi edilen bir olgu nedeniyle literatur isiginda gozden gecirildi.Anahtar Kelimeler: Kavernoma, kavernoz hemanjiorna, konjenital vaskuler malformasyon. Abstract Intracranial Cavernomas (Case Report) in this article we prcsented a patient \vith a congenital cavernoma which was a rare congenital vascular rnalforniation. Patient suffering from epileptic seizures have been operated. Key Words: Cavernoma, cavernous hemangiotna, congenital vascular rnalforniation.