Gunar K. Zagars

Prognostic factors for patients with localized soft-tissue sarcoma treated with conservation surgery and radiation therapy: an analysis of 1225 patients.

Prognostic factors for patients with soft‐tissue sarcoma who are treated with conservative surgery and radiation are documented poorly.

Primary treatment of cystosarcoma phyllodes of the breast

Cystosarcoma phyllodes is a rare sarcoma of the breast. Although surgical removal is the mainstay of treatment, the extent of surgery required (excision vs. mastectomy) and the need for additional local therapy, such as radiotherapy, are unclear. The current study evaluated the rate of local and distant failure, as well as potential prognostic factors, to better define appropriate treatment strategies.

Prognostic factors for clinically localized prostate carcinoma: Analysis of 938 patients irradiated in the prostate specific antigen era

Pretreatment serum prostate specific antigen (PSA) level is a powerful prognostic factor for clinically localized prostate carcinoma. The traditional prognostic factors, T classification and Gleason score, appear to have been relegated to a minor position. This study was conducted to evaluate the relative prognostic roles of PSA, T classification, and Gleason score in a large cohort of men irradiated in the PSA era.

Surgical margins and reresection in the management of patients with soft tissue sarcoma using conservative surgery and radiation therapy.

Patients with localized soft tissue sarcoma (STS) who present to specialist centers after undergoing apparent macroscopic total resection often have a significant incidence of residual tumor and may benefit from reresection of the tumor bed. The potential benefits of such reresection have not been documented adequately.

The fall and rise of prostate-specific antigen. Kinetics of serum prostate-specific antigen levels after radiation therapy for prostate cancer.

Background. The serum kinetics of prostate‐specific antigen (PSA) after radiation therapy for prostate cancer are not well characterized, and the potential prognostic significance of serum half‐lives and of serum doubling times is unclear. This study was designed to address those issues.

Prognostic factors in prostate cancer: Analysis of 874 patients treated with radiation therapy

Background. The outcome of radiation therapy for localized prostate cancer depends on many pretreatment variables that are interrelated in complex ways. A multi‐variate analysis of 874 cases of prostate cancer treated between 1966 and 1988 was conducted. The median length of the follow‐up period after radiation therapy was 6.7 years.

Adjuvant irradiation for cervical lymph node metastases from melanoma

The risk of regional disease recurrence after surgery alone for lymph node metastases from melanoma is well documented. The role of adjuvant irradiation remains controversial.

Surgical management of soft tissue sarcomas of the hand and foot

Soft tissue sarcomas of the hand and foot present unique management challenges. The purpose of the current study study was to determine oncologic outcome, particularly with respect to factors affecting local recurrence, distant recurrence, and disease‐specific survival.

Dedifferentiation of locally recurrent prostate cancer after radiation therapy. Evidence for tumor progression

Background. Untreated or unsuccessfully treated prostatic adenocarcinoma may develop more malignant characteristics as time passes—the phenomenon of tumor progression. Whether this occurs after unsuccessful radiation therapy has not been answered. This study was designed to address that issue.

The T classification of clinically localized prostate cancer. An appraisal based on disease outcome after radiation therapy

Background. This study was performed to evaluate the use of the 1992 International Union Against Cancer (UICC)/American Joint Committee on Cancer (AJCC) T categories for localized prostate cancer treated with radiation therapy and to compare the prognostic power of this system with the Whitmore‐Jewett scheme.