Guncheol Kim
Chungnam National University
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Publication
Featured researches published by Guncheol Kim.
Tetrahedron-asymmetry | 2001
Guncheol Kim; Eun Ju Lee
Abstract Indolizidine alkaloids (−)-167B and (−)-209D were synthesized via an expedient route using hydroacylation and amination.
Bioorganic & Medicinal Chemistry Letters | 2003
Nakjeong Kim; Sun-Kyung Lee; Kyu Yang Yi; Sung-Eun Yoo; Guncheol Kim; Chong Ock Lee; Sung Hee Park; Byung Ho Lee
A series of 4-(N-imidazol-2-ylmethyl)aminobenzopyran analogues, originally designed as K(ATP) openers for ischemic diseases, showed antiangiogenic properties through the inhibition of HUVEC tube formation. Especially one of p-Cl substituted analogues (4c) completely inhibited HUVEC tube formation at 10 microM. The compound 4c significantly inhibited tumor growth by 52% on A549 (human non small cell lung carcinoma) in nude mice xenografts without any significant side effects.
Synthetic Communications | 2008
Guncheol Kim; Ki Youn Lee; Chul-Hwan Yoo
Abstract A new cyclization route, triggered by epoxide opening, has been performed to provide the key intermediates for isoindolobenzapine alkaloids, lennoxamine and chilenine. The epoxide was prepared by the Stille reaction using vinyltributylstannane and the following dioxirane treatment. Cyclization under the treatment of BF3 · OEt2 provided an azepine moiety, and the oxidative cyclization toward the known precursor for the alkaloids has been achieved by reaction with a stoichiometric amount of Pd(OAc)2. This formal synthesis suggests a new route to the alkaloids.
Bulletin of The Korean Chemical Society | 2003
Guncheol Kim; Jae Hak Shim; Jin Hee Kim
(-)-Indolizidine 209D has been synthesized using consecutive amination reactions of compound 11. The precursor was prepared concisely using B-alkyl Suzuki cross coupling of chiral homoallyl amine and vinyl iodide compounds. Reaction: see text.
Chemical Communications | 2007
Tai Hwan Ha; Mi-ra Park; Hye Jung Park; Jae-Sik Choi; Guncheol Kim; Moon Seop Hyun; Bong Hyun Chung
Several nucleophiles such as proteins or poly(ethyleneimine) could be easily conjugated with a 11-(2,4-dinitro-5-fluorobenzene)undecenamide (DFUA) monolayer photochemically prepared on a silicon (100) surface.
Journal of Organic Chemistry | 2003
Jong Yeol Kim; Guncheol Kim; Chung Ryul Kim; Seoung Ho Lee; Joung Hae Lee; Jong Seung Kim
European Journal of Medicinal Chemistry | 2008
Eun Young Song; Navneet Kaur; Mi-Young Park; Yinglan Jin; Kyeong Lee; Guncheol Kim; Ki Youn Lee; Jee Sun Yang; Jae Hong Shin; Ky-Youb Nam; Kyoung Tai No; Gyoonhee Han
Molecular Pharmacology | 2001
Onyou Hwang; Guncheol Kim; Yeon Joo Jang; Seong Who Kim; Guiyong Choi; Hyun Jin Choi; Seon Young Jeon; Don Gyu Lee; Jae Dam Lee
Journal of Organic Chemistry | 1995
Youngha Ryu; Guncheol Kim
Journal of Organic Chemistry | 2003
Guncheol Kim; Sung-do Jung; Eun-Ju Lee; Nakjeong Kim
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Korea Research Institute of Bioscience and Biotechnology
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