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Dive into the research topics where Günther Scheid is active.

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Featured researches published by Günther Scheid.


Journal of Organic Chemistry | 2013

Total Synthesis of Epothilone D: The Nerol/Macroaldolization Approach

Ludger A. Wessjohann; Günther Scheid; Uwe Eichelberger; Sumaira Umbreen

A highly convergent and stereocontrolled synthesis of epothilone D (4) is reported. Key features are a cheap and Z-selective synthesis of the northern half based on nerol and acetoacetate and chromium(II)-mediated Reformatsky reactions as a powerful tool for chemoselective asymmetric carbon-carbon bond formations, including an unusual stereospecific macroaldolization.


European Journal of Organic Chemistry | 2004

A New Route to Protected Acyloins and Their Enzymatic Resolution with Lipases

Günther Scheid; Wouter Kuit; Eelco Ruijter; Romano V. A. Orru; Erik Henke; Uwe T. Bornscheuer; Ludger A. Wessjohann


Tetrahedron-asymmetry | 2004

Synthesis and resolution of a key building block for epothilones: a comparison of asymmetric synthesis, chemical and enzymatic resolution

Günther Scheid; Eelco Ruijter; Monika Konarzycka‐Bessler; Uwe T. Bornscheuer; Ludger A. Wessjohann


Archive | 2003

Epothilone synthesis building blocks iii and iv: asymmetrically substituted acyloins and acyloin derivatives, methods for their production and methods for the production of epothilones b, d and epothilone derivatives

Ludger A. Wessjohann; Günther Scheid; Uwe T. Bornscheuer; Erik Henke; Wouter Kuit; Romano V. A. Orru


Archive | 2001

Epothilone synthesis components iii and iv: asymmetrically substituted acyloins and acyloin derivatives, method for the production thereof and method for the production of epithilone b, d and epothilone derivatives

Ludger A. Wessjohann; Günther Scheid; Uwe T. Bornscheuer; Erik Henke; Wouter Kuit; Romano V. A. Orru


ChemInform | 2008

Synthetic Access to Epothilones‐Natural Products with Extraordinary Anticancer Activity

Ludger A. Wessjohann; Günther Scheid


Organic Synthesis Set | 2008

Chapter 35. Synthetic Access to Epothilones-Natural Products with Extraordinary Anticancer Activity

Ludger A. Wessjohann and; Günther Scheid


European Journal of Organic Chemistry | 2003

A Short and Selective Synthetic Route to (S)-Acyloins via Lipase Catalyzed Hydrolysis (+)-Acyloin Acetates

Günther Scheid; Romano V. A. Orru; Wouter Kuit; Erik Henke; Uwe T. Bornscheuer; Ludger A. Wessjohann


Archive | 2001

Epothilon-synthesebausteine i: unsymmetrisch substituierte acyloine und acyloinderivate, verfahren zu deren herstellung sowie deren verwendung zur herstellung von epothilonen und epothilonderivaten

Ludger A. Wessjohann; Günther Scheid; Uwe T. Bornscheuer; Erik Henke; Wouter Kuit; Romano V. A. Orru


Archive | 2001

Composants synthetiques iii et iv d'epothilone : acyloines et derives d'acyloine a substitution asymetrique, leur procede de production et procede de production d'epothilone b, d et de derives d'epothilone

Ludger A. Wessjohann; Günther Scheid; Uwe T. Bornscheuer; Erik Henke; Wouter Kuit; Romano V. A. Orru

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Wouter Kuit

VU University Amsterdam

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Erik Henke

Memorial Sloan Kettering Cancer Center

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