Guo Lai-jing

e0258 Current clinical practice and guideline application in therapies of ST segment elevation ACS inpatient in a multi-provincial study in China: results of BRIG project

Objective To evaluate the current practice of medications that have been proven effective by evidence-based medicine on inpatients with ST segment elevation ACS in China. Methods 1307 in-patients with ST segment elevation ACS from 64 hospitals across China were received different therapies in hospitals and a standard questionnaire was used to get information of the patients including demographic, treatments and in-hospital outcomes. We analysed the status of application of reperfusion and aspirin, ACEI, β-blocker, LWMH, Clopidogrel and cholesterol lowering agents on ST segment elevation ACS patients. Results 1. The were no significant differences in baseline characteristics between the patients from tertiary hospitals and that from the secondary hospitals. 2. 30.9%–69.4% received reperfusion therapies. 1.3%–62.7% received primary PCI, 1.9%–45.8% received Thrombolysis, and nearly 46.2% did not receive any form of reperfusion. Reperfusion therapy was more often used in tertiary hospitals (48.2%) than in secondary hospitals (6.46%). Thrombolysis was more often in secondary hospitals than that in tertiary hospitals (36.8% vs 14.6%) 3. Percentage of medications in ST ACS patients in different areas: aspirin (88.0%–98). 6%), ACEI (60.5%–84). 4%), β-blocker (55.8%–84.4%), LWMH54.2%–94.2%), Clopidogrel (14.3–88.6), cholesterol lowering agents Statins (51.9%–90.9%); 4. Major in-hospital events and death rates were significantly higher in secondary hospitals than in tertiary hospitals; 5. Mortality and congestive heart failure rate were significantly higher in patients with no reperfusion therapy compared to patients underwent reperfusion. The incidence of combined outcomes (death or MI, and death, MI or Stroke) was also higher in patients without reperfusion therapy 6. Multivariate logistic regression analysis showed that age>75 years, hypertension, diabetes, reperfusion, aspirin, β-blocker, ACEI/ARB inhibitor use were associated independently with in-hospital mortality. Conclusion In the most tertiary hospitals in China the application of medications being proved effective by evidence-based medicine in clinical practice is better than that of the secondary hospitals, but there is a big gap between guidelines and current management of ST segment elevation ACS in China, and the application status in China could be further improved.

GW24-e3931 Correlation Analysis Between Hyperuricemia and Cardiovascular Disease Risk Factors in Population of Healthy Examination

Objectives To understand the relationship between hyperuricemia and cardiovascular disease risk factors. Methods 468 cases with hyperuricemia (HUA) screened out from a company on-the-job personnel healthy medical information, and 508 cases with normal serum uric acid levels (NUA) were randomly selected from the same healthy medical information. Two groups of cardiovascular risk factors were compared with. After an accurate clinical examination and a biochemical evaluation, the results were analysed. Results Participants with hyperuricemia compared to those with normal serum uric acid levels had higher in SBP, DBP, TG, LDL- C and BMI (p < 0.01). Multiple regression analysis showed significant correlation of serum uric acid level and DBP, BMI, TG and fasting glucose levels (p < 0.01 or p < 0.05). Conclusions Serum uric acid concentration are significantly association with cardiovascular disease (CVD) risk factors, and increase risk of CVD.

GW24-e3939 Correlation Analysis Between Hyperuricemia and Cardiovascular Disease Risk Factors in Men

Objectives To understand the relationship between hyperuricemia and cardiovascular disease risk factors in men. Methods 40 cases with hyperuricemia (HUA) screened out from a company on-the-job personnel healthy medical information, and 60 cases with normal serum uric acid levels (NUA) were randomly selected from the same healthy medical information. Two groups of cardiovascular risk factors were compared with. After an accurate clinical examination and a biochemical evaluation,the results were analysed. Results Participants with hyperuricemia compared to those with normal serum uric acid levels had higher in SBP, DBP, TC, LDL- C and BMI (p < 0.05). Multiple regression analysis showed significant correlation of serum uric acid level and BMI, TC (p < 0.01 ). Conclusions Serum uric acid concentration are significantly association with cardiovascular disease (CVD) risk factors, and increase risk of CVD.

GW24-e3917 Analysis of Cardiovascular Disease Risk Factor Cluster and Discussion of Health Management Scheme in Worksite

Objectives To investigate the status of cardiovascular disease risk factors cluster in on-the-job check-up personnel and discuss comprehensive health management scheme. Methods Physical examination was made for 2422 workers. The cardiovascular disease risk factors were analysed, and the suggestions about health management were proposed. Results The present study indicates that 69.2% of subjects have at least one of the following cardiovascular disease risk factors. Clustering of 2 and 3 or more of these risk factors was noted in 22.4% and 16.1% respectively. Men were higher than women in the prevalence of Overweight, obesity, high blood pressure, high blood sugar and high uric acid. Conclusions The risk factors of the cardiovascular disease would increase with the increase of age. Especially, the proportion of overweight and obesity in every age group is significantly higher, and, provides the basis for the health management program of lifestyle intervention.

GW24-e3941 The Medical Result Analysis and Implementation Scheme of Health Management Research in Worksite

Objectives To investigate the health status of on-the-job personnel in Beijing xxx Company. Risk factors affecting the health of workers are analysed, and comprehensive health management scheme is discussed. Methods Physical examination was made for 2422 workers. The results were analysed, and the suggestions about health management were proposed. Results 85 kinds of diseases were detected in Healthy check-up of 2422 subjects, The proportion of which is 74.9%, among of which male and female is 74.3%, and 80.9%, respectively. The male is different from female in in the first ten detected diseases, metabolic disease is mainly for men, while women with gynaecological disease is given priority to.‚ The present study indicates that 69.2% of subjects have at least one of the following cardiovascular disease risk factors. Clustering of 2 and 3 or more of these risk factors was noted in 22.4% and 16.1% respectively. The prevalence of metabolic syndrome in all men are higher women. Conclusions The risk factors of the cardiovascular disease would increase with the increase of age. Especially, the proportion of overweight and obesity in every age group is significantly higher than that of other diseases or risks, and, provides the basis for the health management program of lifestyle intervention.

GW24-e3945 Survey and Research on Related Risk Factors of Fatty Liver Disease in Health Check-up Personnel in Shougang Company

Objectives To explore the relationship between Fatty Liver disease and Gender, Age, body mass index (BMI) in order to provide evidence for its early intervention. Methods A total of 2386 cases were included in this study which was carried out using our hospital Mobile Physical Examination Vehicle in July 2012, with complete information developed. The physical examination results were analysed with statistical method. Results 1) There were 356 persons diagnosed of Fatty Liver disease by B-type ultrasonic scanning in this study. The total prevalence rate of fatty liver was 14.9%. Men had a higher prevalence than women (16.1% vs 4.5%, P < 0.01). The trend of prevalence of Fatty Liver was growing with the age increasing (P < 0.01). 2) For each age group, the prevalence rate of Fatty Liver increased with level growth of BMI (normal, overweight, obesity, p < 0.01). The difference of prevalence rate among all age sub-groups proved statistically significant (p < 0.01) for both normal weight group and overweight group, while p > 0.05 for obesity group. 3) Single factor analysis showed that BMI, blood pressure, blood lipid, FBG, UA and ALT from the fatty liver group was significantly higher than that of the non fatty liver group (P < 0.01). 4) Prevalence of metabolic syndrome was higher in fatty liver group than in non fatty liver group (P < 0.01). 5) Multiple regression analysis showed that Age, FBG, TG, HDL-C, DBP, UA, Overweight and Obesity were risk factors for fatty liver (OR: 1.032, 1.215, 1.379, 1.703, 1.036, 1.005, 6.347, 30.543, respectively). Conclusions High blood pressure, overweight, obesity, dyslipidemia and increasing of UA are closely correlated with fatty liver disease. This is to provide an important evidence for early health management program of Fatty Liver.

GW24-e3942 Correlation Analysis between Concentration of Serum Uric Acid and Risk Factors of Cardiovascular Disease in Population of Healthy Examination

Objectives To analyse relationship between the concentration of serum uric acid and its risk factors of cardiovascular disease among population of healthy examination. Methods Totally 445 subjects were investigated during physical examination by recording genders and age, measuring height, weight, body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP), concentrations of serum uric acid (SUA), total cholesterol (TC), triglycerides (TG), serum high density lipoprotein cholesterol (HDL-C), serum low density lipoprotein cholesterol (LDL-C) and fasting blood glucose (FBG). The physical examination results were analysed with statistical method. Results The concentration of SUA was (309.30 ± 82.16) μmol/L in these population, The concentration of SUA was significantly higher in male than female [(340.20 ± 70.41) μmol/L vs. (231.93 ± 53.57) μmol/L, P < 0.01]. Multiple regression analysis showed significant correlation of serum uric acid level and TC, HDL-C, SBP and BMI (p < 0.01). Conclusions Concentration of SUA is high in population of healthy examination. High concentration of SUA is significantly correlated with cardiovascular risk factors.

e0259 Control status of cholesterol outpatients with heart artery disease in China

Objectives To evaluate the current control status of cholesterol among outpatients with heart artery disease in China. Methods Sixty-four hospitals across China, including 32 secondary hospitals and 32 tertiary hospitals were selected for baseline survey. Fifty outpatients diagnosed heart artery disease were recruited consecutively in each participated hospital. Information for 1806 patients was collected, and control status of cholesterol among the patients was analysed. Results (1) Mean age of the patients was 65.10. Seventy point five percent of the patients were male and 29.5% were female. (2) Overall 26.2% attained the cholesterol goal in the 1806 patients of heart artery disease, the goal attainment rate of cholesterol among male (30.5%) patients was higher than that among female (15.8%) patients. (3) The goal attainment rate of cholesterol was highest in middle China (39.7%) and lowest in northeast area (14.9%) among 7 geographic district (north China, east China, south China, middle China, northeast, northwest, southeast) (p<0.01). Conclusions Only 26.2 heart artery disease patients attained the cholesterol goal, the rate varied significantly among sex, different areas and different degree hospitals. It was essential to pay more atttention on control of cholesterol for secondary prevention of cardiovascular disease.

e0261 Relationship of physical exercise and chest pain recurrence of 2401 coronary artery disease (CAD) patients

Objective To study the relationship of physical exercise and chest pain recurrence of CAD, and if physical exercise could reduce rate of chest pain recurrence and improve quality of life. Methods 64 hospitals across China mainland, involving 2401 patients, 50 out-patients with CAD in each hospital were included and standard questionnaires were used to get relative information on patients’ demographic, physical exercise, chest pain recurrence et al. Results It existed significant differences between exercise and chest pain recurrence. Conclusions Appropriate physical exercise could reduce rate of chest pain recurrence.

e0484 The safety study of tirofiban in patients with STEMI during emergency PCI

Objective To assess the safety of GP IIb/IIIa antagonists tirofiban in patients with ST elevation myocardial infarction (STEMI) during emergency Percutaneous Coronary Intervention (PCI). Method 120 patients with STEMI during emergency PCI, divided into two groups, tirofiban+PCI group (n=60) and primary PCI group (n=60). The two groups are compared on their major adverse cardiovascular events (MACE) rates which consisted of death, new onset myocardial infarction, persistent myocardial ischeamic state, Cardiac function (1eft ventricular ejection fraction) after operation, compression haemostasia time and adverse drug effect while in hospital. Result Major adverse cardiovascular events (MACE) rates in tirofiban+PCI group was higher than that of primary PCI group (10% vs 6.7%); Postoperative heart function was better in tirofiban+PCI group than that in primary PCI group (56.97±8.41 vs 54.15±7.11): There was no difference in severe haemorrhage between the two groups.The bleeding event rates were of higher tendency in tirofiban+PCI group. (8.3% vs 3.3%). APTT and compression haemostasia time of tirofiban+PCI group were significant when prolonged (53.97±10.58 vs 32.51±6.31) p<0.05), but no more bleeding and heamatom events occurred during prolongation. Conclusion GPII b/III a antagonists tirofiban+PCI is a possible safe and effective reperfusion method with STEMI during emergency PCI.