Guo‐Wu Rao

One-pot synthesis of new A-ring fused steroidal pyridines.

The preparation of pyridine rings fused to the 3,4-positions of the steroid nucleus is herein described. These new pyridine derivatives were prepared in good yields by the reaction of propargylamine with 17beta-hydroxyandrost-4-en-3-one, 17alpha-methyl-17beta-hydroxyandrost-4-en-3-one, 17beta-hydroxyestr-4-en-3-one catalyzed by Cu(II). The structure of 17beta-hydroxy-5-ene-androst-3-eno[3,4-b]pyridine was determined by X-ray analysis.

3,6‐Di­phenyl‐1,4‐bis­(p‐tolylsulfonyl)‐1,4‐di­hydro‐1,2,4,5‐tetrazine

The central six-membered ring of the title compound, C28H24N4O4S2, has a boat conformation, in which the N atoms bonded to sulfonyl groups deviate from the plane of the other four atoms by 0.389 (4) and 0.343 (4) A.

3a,5b-Dimethyl-2,3,3a,4,5,5a,5b,6,7,13,13a,13b-dodeca­hydro-1H-8-aza­cyclo­penta­[a]chrysen-3-ol

The title compound, C22H29NO, is built up from five fused rings, four of which are six-membered and one five-membered. The ring adjacent to the five-membered ring adopts a chair conformation.

13-Methyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodeca­hydro-1H-cyclo­penta­[a]phenanthren-17-yl 2-chloro­acetate

The title compound, C20H25ClO3, is built up from four fused rings, three of which are six-membered and one five-membered. The ring adjacent to the five-membered ring adopts a chair conformation.

1-Chloro-4-oct­yloxy-10-thia­anthracen-9-one

In the title compound, C21H23ClO2S, the three fused rings are roughly coplanar. The two benzene rings are twisted by a dihedral angle of 7.15 (15)°.