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Publication
Featured researches published by Guosong Zhang.
Molecules | 2015
Guosong Zhang; Peng-Yi Hu; Dong-Xun Li; Ming-Zhen He; Xiaoyong Rao; Xiaojian Luo; Yue-Sheng Wang; Yu-Rong Wang
The aim of this study was to develop and optimise a saikosaponin a and saikosaponin d compound liposome (SSa-SSd-Lip) formulation with reduced hemolysis and enhanced bioavailability. A screening experiment was done with Plackett–Burman design, and response surface methodology of five factors (EPC/SSa-SSd ratio, EPC/Chol ratio, water temperature, pH of PBS, and ultrasound time) was employed to optimise the mean diameter, entrapment efficiency of SSa and SSd, and the reduction of hemolysis for SSa-SSd-Lip. Under the optimal process conditions (EPC/SSa-SSd ratio, EPC/Chol ratio, water temperature and pH of PBS were 26.71, 4, 50 °C and 7.4, respectively), the mean diameter, the entrapment efficiency of SSa, the entrapment efficiency of SSd and the hemolysis were 203 nm, 79.87%, 86.19%, 25.16% (SSa/SSd 12.5 mg/mL), respectively. The pharmacokinetic studies showed that the SSa-SSd-Lip had increased circulation time, decreased Cl, and increased AUC, MRT and T1/2β (p < 0.05) for both SSa and SSd after intravenous administration in comparison with solution.
Archive | 2010
Yuesheng Wang; Hui Jian; Xiaojian Luo; Yi Rao; Meimei Fan; Guosong Zhang; Yao Zhang; Xiao Zhou
Archive | 2012
Hongning Liu; Dongxun Li; Xiaojian Luo; Guosong Zhang; Wenyong Liu; Xiaoyong Rao; Shilin Yang; Hui Jian; Jingbang Lei; Qi Wang
Archive | 2011
Guosong Zhang; Yuesheng Wang; Zhibin Zeng; Aiping Lv; Yi Rao; Xiaojian Luo; Xiaoyong Rao
Archive | 2011
Xiaoyong Rao; Xiaojian Luo; Hongning Liu; Shilin Yang; Lanying Chen; Guosong Zhang; Liang Fu; Kai Huang
Archive | 2012
Guosong Zhang; Hanbin Hong; Xiaojian Luo; Yuesheng Wang; Meimei Fan
Archive | 2011
Dongxun Li; Xiaojian Luo; Hongning Liu; Shilin Yang; Wenyong Liu; Guosong Zhang
Archive | 2010
Kai Huang; Xiaojian Luo; Xiaoyong Rao; Yuesheng Wang; Shilin Yang; Guosong Zhang
Archive | 2009
Aiping Lu; Xiaojian Luo; Xiaoyong Rao; Zhibin Zeng; Guosong Zhang; Hongguang Zhong; Tao Zhou
Archive | 2006
Aiping Lu; Shilin Yang; Yuesheng Wang; Xiaojian Luo; Yi Rao; Guosong Zhang