Guy A. Settipane

Asthma caused by FD&C approved dyes.

Abstract A case of severe intractable asthma due to sensitivity to certain of the FD&C approved dyes, notably Tartrazine (yellow No. 5), is reported. These dyes are commonly used to color drug tablets and capsules, as well as many foods. Required listing of these dyes on drug and food packages might be life-saving.

Aspirin intolerance and recurrent urticaria in normal adults and children. Epidemiology and review.

The frequency of aspirin intolerance by history in 2,592 normal individuals was 0.3%. Although the frequency of aspirin intolerance was similar in adults and children, the bronchospastic type predominated in adults, and only the urticarial regardless of etiology, was significantly greater in adults than in children. The frequency of recurrent urticaria, regardless of etiology, was significantly greater in adults than in children (3.8% vs. 0.3, P<0.001). In adults the frequency of aspirin intolerance was over 20 times greater in individuals with recurrent urticaria than in normal individuals (6.5% vs. 0.3%, P<0.001).

Allergic rhinitis--update.

More than 20% of the general population is afflicted with a common medical disorder—allergic rhinitis. Recent research in rhinitis has brought about much new information and created possibilities for new means and methods of diagnosis and treatment.

Prevalence of bee sting allergy in 2,010 girl scouts.

In a previous investigation from the clinic, the prevalence of Hymenoptera sting allergy was found to be 0.40 per cent in a population of 4,992 boy scouts (5) between the ages of II to 16 years. This past report represented one of the first epidemiologic studies done on bee sting allergy but is incomplete in that comparative figures are not available for females. The purpose of this study is to determine the prevalence of Hymenoptera sting allergy in females using a comparable study group exposed to similar environmental conditions.

Asthma and hyperthyroidism

Abstract Case histories of five patients with severe, intractable asthma, who were later found to have concomitant hyperthyroidism, are presented. Although the frequency of these two diseases in the same individual appears to be small, diagnosis and therapy of the hyperthyroid state provided dramatic amelioration of the asthma.

HYMENOPTERA ALLERGY: PRECIPITIN AND PASSIVE CUTANEOUS ANAPHYLAXIS TESTS IN HUMAN AND RABBIT SERA

Compared to the frequency of asthma, and/or allergie rhinitis, of about 25 per eent (5) , Llymenoptera alleigy represents a small but complex group of patients whose prevalence may be as low as 0.4 per cent (12). These latter patients make up for their lack in numbers by frequently presenting themselves in hfe threatening situatiojis. Atypical reactions to bee sting have been reported both in the treated and untreated Hymenoptrea allergy cases. Although most bee sting allergy patients are success I ulJy hyposensiti/,ed, a few individuals who have undergone a full hyposensitization progran; with Hymenoptera extract were unimproved and again have experienced anaphylaxis with a subsequent sting (6) . Other individuals have experienced peculiar reactions, some with an onset of anaphylaxis occurring an hour or more after the sting. Barnard (2) has reported fatal bee sting reactions occurring as long as several days later. In this study, immunological procedures were undertaken as a possible aid in understanding some of these unusual reactions to Hymenoptrea allergy.

ATMOSPHERIC POLLEN AND MOLD SURVEY.

An eight year survey of daily pollen and mold counts from April 1 to September 30 in Providence, R. I., is presented. Each pollen season is subdivided into “peak” season, “average” season, and “fringe” area. The results are illustrated in Fig. 1. The effect of hurricanes on atmospheric pollens is discussed.Abstract An eight year survey of daily pollen and mold counts from April 1 to September 30 in Providence, R. I., is presented. Each pollen season is subdivided into peak season, average season, and fringe area. The results are illustrated in Fig. 1. The effect of hurricanes on atmospheric pollens is discussed.

Triamcinolone Acetonide Aqueous Nasal Spray (Nasacort Aqueous) Relieves the Symptoms of Seasonal Ragweed Allergic Rhinitis

Triamclnolone Acetonide Aqueous Nasal Spray (Nasacort Aqueous] Relieves the Symptoms of Seasonal Ragweed Allergic Rhinitis GUY A. SETrlPANE, MD (presenter), PHILIP E. KORENBLAT, MD, JOHN WINDER, MD, WILLIAM R. LUMRY, MD, JEAN MURPHREE, MD, VIVIAN B. ALDERFER, PHD, BRANDON SIMPSON, and JOSEPH A. SMITH, MD, Providence, R.I., St. Louis, Mo., Sylvania, Ohio, Dallas and San Antonio, Tex., and Collegeville, Pa.