Gwan Woo Lee
Dankook University
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Featured researches published by Gwan Woo Lee.
Korean Journal of Anesthesiology | 2015
Byung Moon Choi; Soo Han Lee; Sang Mee An; Do Yang Park; Gwan Woo Lee; Gyu-Jeong Noh
Background The objective of this study was to investigate the time-course of the expression of TNF-α, IL-6, and IL-1β after L5 spinal nerve transection (SNT), and to determine the effect of small interfering RNA (siRNA) targeting these cytokines on neuropathic pain. Methods Rats received control siRNA (CON group, n = 80) or a cocktail of siRNAs targeting these cytokines (COCK group, n = 70). The siRNAs were given via intrathecal catheter 1 d prior to SNT, on the operation day, and 1, 2 and 3 d postoperatively. Behavioral tests and levels of the cytokine mRNAs and proteins as well as glial cell activity were following the L5 SNT. Results In the CON group, TNF-α and IL-1β mRNA levels increased immediately after SNT and remained high for 6 d, while IL-6 transcripts only began to increase after 12 h. TNF-α and IL-1β mRNA levels in the COCK group were lower than in the CON group at all time points (P < 0.05). In the behavioral tests, allodynia and hyperalgesia were significantly lower in the COCK group from 2 d after SNT (P < 0.05). Conclusions The time courses of TNF-α, IL-6 and IL-1β mRNA expression after L5 SNT differ. RNA interference may be a method of reducing the development of mechanical allodynia and hyperalgesia in response to nerve injury.
Korean Journal of Anesthesiology | 2015
Byung Moon Choi; Soo Han Lee; Sang Mee An; Do Yang Park; Gwan Woo Lee; Gyu-Jeong Noh
[This corrects the article on p. 159 in vol. 68, PMID: 25844135.].
Korean Journal of Anesthesiology | 2015
Hyun-Jung Shin; Hyo-Seok Na; Young-Tae Jeon; Gwan Woo Lee; Sang-Hwan Do
Background Hydroxyethyl starch (HES) solutions are used as plasma expanders for correcting hypovolemia, but can lead to impaired coagulation. We evaluated the changes in hematological and hemostatic profiles with three types of HES. Methods Patients were randomized to receive volume replacement with 10% pentastarch 260/0.45 in 0.9% saline (Group-PEN, n = 25), 6% tetrastarch 130/0.4 in 0.9% saline (Group-TETS, n = 25), or 6% tetrastarch 130/0.4 in a balanced electrolyte solution (Group-TETB, n = 25). Coagulation was assessed using rotational thromboelastometry (ROTEM®) and other laboratory tests were performed, including measurements of hematological and hemostatic parameters and electrolytes. Results Post-operative ROTEM® parameters changed toward hypocoagulable states in all groups. The post-operative parameters of EXTEM and FIBTEM were more impaired in Group-PEN than in Group-TETB. The percentage change in INTEM clot formation time (P = 0.004) and α-angle (P = 0.003) were smaller in Group-TETS and Group-TETB than in Group-PEN. The percentage change in the FIBTEM maximum clot firmness was greatest in Group-PEN (P = 0.011). The international normalized ratio of prothrombin time (P < 0.001) and the activated partial thromboplastin time (P < 0.001) were significantly prolonged in Group-PEN compared to those of Group-TETB. Conclusions The 6% HES 130/0.4 in a balanced electrolyte solution seemed to have less of an impact on blood coagulation than the 10% HES 260/0.45. No differences in hemostatic profile were observed between the balanced electrolyte and saline-based 6% HES 130/0.4.
Korean Journal of Anesthesiology | 2014
Jeong Heon Park; Min A Kwon; Dong Hee Kim; Seok-Kon Kim; Dae Geun Jeon; Jaegyok Song; Seung Heon Ji; Gwan Woo Lee; Bong Jin Kang
Pulmonary aspiration of gastric contents is one of the most frightening complications during anesthesia. Although pulmonary aspiration of gastric contents in general surgical patients is not common and resulting long-term morbidity and mortality are rare, severe hypoxemia and other sequelae of pulmonary aspiration continue to be reported. We report a case of massive aspiration of gastric contents during induction of general anesthesia, resulting in cardiac arrest due to severe pulmonary hypertension and myocardial infarction. Sustained cardiac arrest and shock that did not respond the conventional resuscitation was successfully treated using milrinone. The patient was discharged without complications in 20 days.
Korean Journal of Anesthesiology | 2009
Bong Jin Kang; Seok-Kon Kim; Gwan Woo Lee; Min A Kwon; Jae Gyok Song; Seung Chul Ahn
BACKGROUND Although there have been reports showing the changes of the auditory brainstem response (ABR) waves by propofol, no detailed studies have been done at the level of brainstem auditory circuit. So, we studied the effects of propofol on the postsynaptic currents of the medial nucleus of the trapezoid body (MNTB)-lateral superior olive (LSO) synapses by using the whole cell voltage clamp technique and we compared this data with that obtained by the ABR. METHODS 5 rats at postnatal (P) 15 days were used for the study of the ABR. After inducing deep anesthesia using xylazine 6 mg/kg and ketamine 25 mg/kg, the ABRs were recorded before and after intraperitoneal propofol injection (10 mg/kg) and the effects of propofol on the latencies of the I, III, and V waves and the I-III and III-V interwave intervals were evaluated. Rats that were aged under P11 were used in the voltage clamp experiments. After making brainstem slices, the postsynaptic currents (PSCs) elicited by MNTB stimulation were recorded at the LSO, and the changes of the PSCs by the bath application of propofol (100 microM) were monitored. RESULTS We found small, but statistically significant increases in the latencies of ABR waves III and V and the interwave intervals of I-III and III-V by propofol. However, no significant changes were observed in the glycinergic or glutamatergic PSCs of the MNTB-LSO synpases by the application of propofol (100 microM). CONCLUSIONS Glycinergic or glutamatergic transmission of the MNTB-LSO synapses might not contribute to the propofol-induced changes of the ABR.
Korean Journal of Anesthesiology | 2007
Dae Geun Jeon; Seok Kon Kim; Gwan Woo Lee; Sung Ho Hong; Sung Hoon Kim
Korean Journal of Anesthesiology | 1996
Gwan Woo Lee; Seok Kon Kim; Kye Young Kim
Korean Journal of Anesthesiology | 2008
Sung Ho Hong; Gwan Woo Lee
The Korean Journal of Pain | 2006
Min A Kwon; Hyo Won Park; Ae Ryong Lee; Tae Hyung Kim; Gwan Woo Lee; Seok Kon Kim; Duck Hwan Choi
Korean Journal of Anesthesiology | 2006
Jin Hun Chung; Sang Wook Park; Seok Kon Kim; Dae Geun Jeon; Gwan Woo Lee