Gyula Vincze

An Energy Analysis of Extracellular Hyperthermia

The classical hyperthermia effect is based on well‐focused energy absorption targeting the malignant tissue. The treatment temperature has been considered as the main technical parameter. There are discussions about the mechanism and control of the process because of some doubts about the micro‐mechanisms. The main idea of the extracellular hyperthermia is to heat up the targeted tissue by means of electric field, keeping the energy absorption in the extracellular liquid. This produces a temperature gradient and connected heat flow through the cell membrane, which initializes numerous nonequilibrium thermal microprocesses to destroy the cell membrane. Furthermore, before the heat shock activates the intracellular heat shock protein (HSP) mechanisms, thecell membrane has been already compromised, therefore the HSP synthesis in the cells starts secondarily only after the membrane damage. The process could explain why the nonuniform and basically unsatisfactorily high temperature locoregional hyperthermia could be effective.

Bio-response to white noise excitation

Pink (1/f-) noise is one of the most common behaviors of biosystems. This paper is devoted to clarifying the stochastic answer given to white-noise excitation of bio-systems. It is assumed that a living system in general is a bifurcative self-organizing system, and has cyclic symmetry with infinite degrees of freedom, and stationary random stochastic processes characterize their dynamism. We show that this bifurcation characterizes all levels of bioactivity, and the white-noise excited biosystem has a filter function, and generates a pink-noise spectrum. Environmental white-noise electromagnetic excitation (like ‘electrosmog’ in general) is filtered by the biosystem, and it gives a characteristic pink-noise answer-signal to this excitation.

Do field-free electromagnetic potentials play a role in biology?

All bio-systems are imperfect dielectrics. Their general properties however cannot be described by conventional simple electrodynamics; the system is more complex. A central question in our present paper is centered on a controversial debate of the possible effect of the zero fields (only potentials exist). We show that the identical use of the “field-free,” “curl-free,” and “force-free” terminologies is incorrect, there have definitely different meanings. It is shown that the effective electro-dynamical parameters that describe and modify living systems are the potentials and not the fields. We discuss how the potentials have a role in biological processes even in field-free cases.

Effect of Curl-Free Potentials on Water

Living objects are complex systems with various harmonized chemical, thermodynamical, and quantum-mechanical processes in aqueous electrolyte environment. We had studied the effect of curl-free magnetic vector-potential on the matrix of the living matter, on the water. The discussed theoretical considerations are in harmony with the presented simple experiments. It is shown that the vector-potential is actually an effective electro-dynamical parameter which could modify the processes in living systems.

An allometric approach of tumor-angiogenesis

Angiogenesis is one of the main supporting factors of tumor-progression. It is a complex set of interactions together with hypoxia and inflammation, regulating tumor growth. The objective of this study is to examine the effect of angiogenesis with an allometric approach applied to angiogenesis and the regulating factors. The results show that allometry has the potential to describe this aspect, including the sigmoid-like transport function. There are particular conditions under which the complex control maximizes the relative tumor mass. Linear growth of malignancy diameter with an allometric approach was proven.

Nonequilibrium Thermodynamic and Quantum Model of a Damped Oscillator

We describe the linearly damped harmonic quantum oscillator in Heisenberg’s interpretation by Onsager’s thermodynamic equations. Ehrenfest’s theorem is also discussed in this framework. We have also shown that the quantum mechanics of the dissipative processes exponentially decay to classical statistical theory.