H. Abdel-Ghany

Synthesis and biological activity of dihydroimidazole and 3,4-dihydrobenzo[4,5]imidazo[1,2-a][1,3,5]triazins.

Reaction of 2-guanidinobenzimidazole with halogenated active methylenes and ketones gave dihydroimidazole and 3,4-dihydrobenzo[4,5]imidazo [1,2-a][1,3,5]triazin derivatives in very good yield. The anti-bacterial evaluation of the newly synthesized products against broad spectrum of bacteria was performed. Most of products showed high inhibitory effect. All compounds have been characterized based on IR, (1)H NMR, (13)C NMR and Mass spectra.

Synthetis of Pyrrole, and Andpyridinone Pyrimidinone Derivatives Using PTC Conditions

Abstract The reaction of anilinomethylenemalononitrile 1 or 1,4-di (malononitrilemethyleneamino) benzene 7 with some reactive halo compounds in a one-pot reaction under PTC conditions affords a new series of pyrrole and pyridinone compounds. The reaction of compounds 1 or 7 with ethyl chloroformate gives the corresponding esters which underwent cyclization on reaction with different amino compounds affording the pyrimidinone derivatives.

A Novel Synthesis of Heterocyclic Compounds Derived from α-Ketoketene S,S-Acetal

Abstract Novel heterocyclic compounds were prepared by the reaction of 2-acetyl-2-oxopropylidene s,s-acetal with different amino compounds namely, hydrazine hydrate, phenylhydrazine, guanidine hydrochloride, thiosemicarbazide, o-phenylenediamine, o-aminophenol or o-amino-thiophenol in different molar ratios.

Synthesis and Reactions of Some Pyrazine Derivatives

Abstract The pharmacodynamic properties1-3 of substituted amino pyrazines as well as their importance in the synthesis of pteridine and other polyfused heterocyclic systems is well known4,5. In this investigation we aim to prepare a new series of condensed heterocyclic systems containing the pyrazine nucleus.

2-Amino-4-phenyl-4H,10H-1,3,5-triazino[1,2-a]benzimidazol-3-ium chloride.

2-Guanidinobenzimidazole condenses with benzaldehyde in the presence of hydrochloric acid to form 2-amino-3,4-dihydro-4-phenyl-1,3,5-triazino[1,2-a]benzimidazole, which was isolated as its hydrochloride, C15H14N5 +·Cl−. The positive charge of the cation is formally placed on the double-bonded N atom of the dihydrotriazine ring. The six-membered dihydrotriazine that is fused with the benzimidazole ring system is relatively flat (r.m.s. deviation = 0.106 Å), with the methine C atom deviating most [0.164 (1) Å] from the mean-square plane. The phenyl ring connected to the methine C atom is disordered over two positions in a 0.558 (1):0.442 (1) ratio; the two orientations are aligned at 85.1 (1) and 89.6 (1)° with respect to the dihydrotriazine ring. In the crystal, adjacent cations and anions are linked by N—H⋯N and N—H⋯Cl hydrogen bonds, generating a double chain running along the b axis.

4-(4-Chloro-benz-yl)-5-methyl-2-phenyl-1H-pyrazol-3(2H)-one.

The five-membered ring of the title compound, C17H15ClN2O, is almost planar (r.m.s. deviation = 0.008 Å), and its phenyl subsitutent is aligned at 34.9 (1)° with respect to this ring. The angle at the methylene C atom is opened to 116.4 (2)°. In the crystal, adjacent molecules are linked by an N—H⋯O hydrogen bond, generating a linear chain along the a axis.