H. Balner

A METHOD TO RELATE LEUKOCYTE ANTIGENS AND TRANSPLANTATION ANTIGENS IN MONKEYS.

Isoimmunized Rhesus monkeys produce agglutinins against leukocytes from a certain proportion of individuals of a random population of Rh monkeys. Preliminary evidence is presented that there is a parallelism between agglutinating reactivity against the leukocytes and the intensity of the homograft reaction against a skin graft from a particular individual. It is suggested that sensitization to transplantation antigens may be reflected in reactivity against corresponding leukocyte antigens.

THE MAJOR HISTOCOMPATIBILITY COMPLEX OF RHESUS MONKEYS: XIII. CURRENT KNOWLEDGE OF DR AND OTHER B‐CELL SPECIFIC ANTIGENS †

Results of a population study with all currently available B‐cell specific alloantisera indicate that eight antigens controlled by the RhLA‐linked DR locus can now be identified. This leaves a gene frequency of about 0.15 for unidentified or ‘blank’ antigens of that locus. Of the nine identifiable la antigens which are not controlled by the DR locus, three or four may form the basis of a second series which is probably also controlled by the RhLA region.

THE MAJOR HISTOCOMPATIBILITY COMPLEX OF RHESUS MONKEYS, RhLA: XV. CHEMICAL CHARACTRIZATIONS OF DR LOCUS ANTIGENS AND ANTIGEN 48

Immunoprecipitaon studies of the rhesus monkey major histocompatibility system have shown that the RhLA‐DR locus codes for class II antigens with molecular features that are homologous to the class II antigens coded for by the human HLA‐dR locus, The products of another alloantigenic RhLA‐linked locus of the rhesus monkey, called ‘48’, is provisionally characterized as a class I system.