H. D. Moed

Über eine neue adrenalincarbonsäure und einige ihrer derivate

Abstract Synthesis and pharmacological properties of a new carboxylic acid of epinephrine and of some derivatives are reported. The carboxylic acid produced qualitatively the same effects on blood pressure and denervated nictitating membrane of the cat as epinephrine, the relative potency being 0.0003. The effects on the blood pressure could be reversed by previous administration of adrenalytics. We believe that the effects on the blood pressure and the nictitating membrane are caused by admixture of epinephrine contained in the original substance. An enzymatic decarboxylation in vitro could not be observed. On the other hand, the effects of the esters derived from the new epinephrine carboxylic acid were similar to those of the iso propylnorepinephrine. The most active ester derived from the new acid equalled iso propylnorepinephrine in its potency on all test subjects. In all experiments, the increasing effects on heart frequency, the bronchodilating and the depressing effect on the blood pressure of the esters run parallel. The corresponding derivatives of the p-oxyephedrin were practically completely ineffective. The connections between chemical constitution and pharmacological activity is discussed.