H. Dittmann

Influence of sampling site and flow area on cardiac output measurements by Doppler echocardiography

In 40 patients cardiac output was simultaneously determined by pulsed Doppler echocardiography and thermodilution (range 4.0 to 10.2 liters/min). The sample volume was located in the center of the mitral anulus, at the tips of the mitral leaflets and in the center of the aortic anulus. Circular cross-sectional areas of the mitral anulus, aortic anulus and aortic bulbus were calculated from M-mode and two-dimensional echocardiographic diameters. The varying short axis of the elliptical mitral opening area was obtained from the diastolic leaflet separation in the M-mode, and the long axis was derived from the maximal mitral orifice area or mitral anulus diameter. Cardiac output was calculated by multiplying time-velocity integrals with the different areas and heart rate. Doppler flow measurements correlated significantly with the thermodilution method (r = 0.79 to 0.93). Flow measurements at the aortic anulus were most accurate (r = 0.93, SEE = 0.589 liter/min) if the annular area was derived from the M-mode tracing. Measurement of the anulus in the apical five chamber view yielded a significant underestimation and the area of the aortic bulbus provided an overestimation of cardiac output. Left ventricular inflow was underestimated at the mitral leaflet tips and overestimated at the mitral anulus. The accuracy of pulsed Doppler cardiac output measurements strongly depends on the assumed flow area and sampling site. Both should be determined at the same level in the inflow or outflow tract of the left ventricle. Measurement of cardiac output in the center of the aortic anulus provided the highest accuracy.

Accuracy of doppler echocardiography in quantification of left to right shunts in adult patients with atrial septal defect

In previous experimental and pediatric studies, the ratio of pulmonary to systemic flow (Qp/Qs) was accurately estimated by Doppler echocardiography in various cardiac shunt lesions. The purpose of this study was to assess the accuracy of pulsed Doppler echocardiography in determining the magnitude of shunt flow in adult patients with an ostium secundum type atrial septal defect. In 32 patients with high quality echocardiograms and excellent Doppler signals, blood flow was measured in the right and left ventricular outflow tract by Doppler echocardiography. In 16 patients without heart disease, the correlation (r) between systemic (Qs) and pulmonary (Qp) blood flow was 0.96 (SEE = 0.417 liter/min, y = 1.05x - 0.21) and the mean Qp/Qs ratio was 1.01 +/- 0.09. In 16 patients with an atrial septal defect, the Qp/Qs ration measured by oximetry ranged from 1.34 to 4.61 and by pulsed Doppler echocardiography from 1.31 to 4.46 (p = NS). In these 16 patients, the correlation between the Qp/Qs ratio determined by oximetry and pulsed Doppler echocardiography was significant (r = 0.82, SEE = 0.54). In the total group of 32 patients, the correlation was stronger (r = 0.93, SEE = 0.37). Systematic differences between the invasive and noninvasive shunt calculations did not occur. Thus, in adult patients with an atrial septal defect of the secundum type and high quality echocardiograms, the magnitude of left to right shunt can be accurately assessed by pulsed Doppler echocardiography. In the absence of pulmonary hypertension, pulsed Doppler echocardiography provides precise information for the decision to undertake conservative or operative treatment.

[Value of 2-D echocardiography in the detection of stress-induced wall-motion abnormalities in coronary heart disease--a comparison with biplane cineventriculography].

SummaryTo determine the accuracy of echocardiography in assessment of exercise-induced wall motion abnormalities, the results of stress-echocardiography were compared with exercise-cineventriculography.In 56 consecutive patients biplane cineventriculography at rest and immediately after supine bicycle exercise was performed. Cross-sectional echocardiography was obtained using the apical 2- and 4-chamber view for LV imaging under identical exercise conditions.In 6 of the 56 patients 2-D echo, in 8 patients LV-angio, and in 2 patients both methods were of inadequate quality during exercise.Thus, in 40 patients (34 patients had coronary artery disease) local wall motion of 360 wall segments was analysed. 49 segments (14%) of 24 patients showed exercise-induced ischemic wall motion abnormalities during cineventriculography. Only 24 of these 49 asynergics (49%) were also detected by 2-D-echo. Using cross-sectional echocardiography, ischemia related wall motion abnormalities were best detected lateraly and septaly, whereas apical asynergies were identified in 3 of 12 segments only.Thus, the clinical value of exercise 2-D echo as a screening method in patients suspected to have coronary artery disease is limited and restricted to patients with excellent visualization of the left ventricular endocardium.To determine the accuracy of echocardiography in assessment of exercise-induced wall motion abnormalities, the results of stress-echocardiography were compared with exercise-cineventriculography. In 56 consecutive patients biplane cineventriculography at rest and immediately after supine bicycle exercise was performed. Cross-sectional echocardiography was obtained using the apical 2- and 4-chamber view for LV imaging under identical exercise conditions. In 6 of the 56 patients 2-D echo, in 8 patients LV-angio, and in 2 patients both methods were of inadequate quality during exercise. Thus, in 40 patients (34 patients had coronary artery disease) local wall motion of 360 wall segments was analysed. 49 segments (14%) of 24 patients showed exercise-induced ischemic wall motion abnormalities during cineventriculography. Only 24 of these 49 asynergics (49%) were also detected by 2-D-echo. Using cross-sectional echocardiography, ischemia related wall motion abnormalities were best detected laterally and septaly, whereas apical asynergies were identified in 3 of 12 segments only. Thus, the clinical value of exercise 2-D echo as a screening method in patients suspected to have coronary artery disease is limited and restricted to patients with excellent visualization of the left ventricular endocardium.

Wertigkeit der 2-D-Echokardiographie zur Erkennung belastungsinduzierter Wandbewegungsstörungen bei koronarer Herzerkrankung — Ein Vergleich mit der biplanen Cineventrikulographie

SummaryTo determine the accuracy of echocardiography in assessment of exercise-induced wall motion abnormalities, the results of stress-echocardiography were compared with exercise-cineventriculography.In 56 consecutive patients biplane cineventriculography at rest and immediately after supine bicycle exercise was performed. Cross-sectional echocardiography was obtained using the apical 2- and 4-chamber view for LV imaging under identical exercise conditions.In 6 of the 56 patients 2-D echo, in 8 patients LV-angio, and in 2 patients both methods were of inadequate quality during exercise.Thus, in 40 patients (34 patients had coronary artery disease) local wall motion of 360 wall segments was analysed. 49 segments (14%) of 24 patients showed exercise-induced ischemic wall motion abnormalities during cineventriculography. Only 24 of these 49 asynergics (49%) were also detected by 2-D-echo. Using cross-sectional echocardiography, ischemia related wall motion abnormalities were best detected lateraly and septaly, whereas apical asynergies were identified in 3 of 12 segments only.Thus, the clinical value of exercise 2-D echo as a screening method in patients suspected to have coronary artery disease is limited and restricted to patients with excellent visualization of the left ventricular endocardium.To determine the accuracy of echocardiography in assessment of exercise-induced wall motion abnormalities, the results of stress-echocardiography were compared with exercise-cineventriculography. In 56 consecutive patients biplane cineventriculography at rest and immediately after supine bicycle exercise was performed. Cross-sectional echocardiography was obtained using the apical 2- and 4-chamber view for LV imaging under identical exercise conditions. In 6 of the 56 patients 2-D echo, in 8 patients LV-angio, and in 2 patients both methods were of inadequate quality during exercise. Thus, in 40 patients (34 patients had coronary artery disease) local wall motion of 360 wall segments was analysed. 49 segments (14%) of 24 patients showed exercise-induced ischemic wall motion abnormalities during cineventriculography. Only 24 of these 49 asynergics (49%) were also detected by 2-D-echo. Using cross-sectional echocardiography, ischemia related wall motion abnormalities were best detected laterally and septaly, whereas apical asynergies were identified in 3 of 12 segments only. Thus, the clinical value of exercise 2-D echo as a screening method in patients suspected to have coronary artery disease is limited and restricted to patients with excellent visualization of the left ventricular endocardium.

Value of a modified continuity equation method to quantify mitral valve area in patients with mitral stenosis and sinus rhythm

SummaryTo quantify valve area in mitral stenosis, a modified continuity equation method using continuous wave Doppler and thermodilution measurements was applied. In 14 patients with mitral stenosis and sinus rhythm (age: 49±11 years), transmitral flow velocity was recorded by continuous wave Doppler during right and left heart catheterization. Mitral valve area was calculated by three different methods: 1. According to the continuity equation, stroke volume (thermodilution technique) was divided by the registered time velocity integral of the mitral stenotic jet (continuous wave Doppler). 2. Mitral valve area was calculated by the pressure half-time method. 3. Simultaneous pulmonary capillary wedge and left ventricular pressure measurements were used for determination of mitral valve area according to the Gorlin formula. The mitral valve area determined by application of the continuity equation (y) showed a close correlation to the valve area calculated by the Gorlin equation (x):y=0.73x+0.12, SEE=0.11 cm2,r=0.88,P<0.001. In contrast, the correlation between mitral valve area determined by pressure half-time (y) and the Gorlin formula (x) was not as good:y=0.77x+0.11, SEE=0.26 cm2,r=0.65,P<0.05. Thus, the continuity equation method using combined continuous wave Doppler and thermodilution technique allows a valid determination of mitral valve area. In patients with mitral stenosis and sinus rhythm, this technique is superior to the noninvasive determination of mitral valve area by the conventional pressure half-time method.

Die Doppler-echokardiographische Quantifizierung des regurgitierenden Blutvolumens bei Patienten mit Mitralinsuffizienz

The purpose of this study was to assess the accuracy and clinical utility of pulsed Doppler echocardiography in determining the regurgitant fraction in patients with pure mitral regurgitation. In 30 unselected consecutive patients with mitral regurgitation and in 20 patients without valvular heart disease pulsed Doppler echocardiography was performed to measure blood flow at the mitral and aortic valve. The regurgitant blood volume was calculated as the difference of the stroke volumes measured at the mitral and aortic valve. The regurgitant fraction was computed as regurgitant blood volume/mitral flow. By cardiac catheterization regurgitant blood volume and regurgitant fraction were obtained from the left ventricular angiographic stroke volume and the stroke volume measured by thermodilution. Five patients were excluded because of technically poor left ventricular angiograms. In 4 patients with mitral regurgitation measurement of the regurgitant blood volume and regurgitant fraction was impossible by Doppler because of poor ultrasound signal quality. In 21 patients with mitral regurgitation the correlations between the invasive and the Doppler measurements were significant (regurgitant blood volume: r = 0.89, SEE = 20.9 ml; regurgitant fraction: r = 0.91, SEE = 7.1%). However, the mean percent error of the regurgitant fraction measurement (12.0 +/- 11.6%) was smaller than of the regurgitant blood volume measurement (24.9 +/- 17.0%). In the control group the regurgitant blood volume ranged between -25.1 ml and 11.6 ml and the regurgitant fraction between -17.7% and 12.4%. Thus, pulsed Doppler echocardiography is clinically useful in determination of the regurgitant fraction in 84% of unselected adult patients with pure mitral regurgitation. The Doppler method is limited in the diagnosis and quantification of mild regurgitation.(ABSTRACT TRUNCATED AT 250 WORDS)SummaryThe purpose of this study was to assess the accuracy and clinical utility of pulsed Doppler echocardiography in determining the regurgitant fraction in patients with pure mitral regurgitation. In 30 unselected consecutive patients with mitral regurgitation and in 20 patients without valvular heart disease pulsed Doppler echocardiography was performed to measure blood flow at the mitral and aortic valve. The regurgitant blood volume was calculated as the difference of the stroke volumes measured at the mitral and aortic valve. The regurgitant fraction was computed as regurgitant blood volume/mitral flow. By cardiac catheterization regurgitant blood volume and regurgitant fraction were obtained from the left ventricular angiographic stroke volume and the stroke volume measured by thermodilution. Five patients were excluded because of technically poor left ventricular angiograms. In 4 patients with mitral regurgitation measurement of the regurgitant blood volume and regurgitant fraction was impossible by Doppler because of poor ultrasound signal quality. In 21 patients with mitral regurgitation the correlations between the invasive and the Doppler measurements were significant (regurgitant blood volume:r=0.89, SEE=20.9 ml; regurgitant fraction:r=0.91, SEE=7.1%). However, the mean percent error of the regurgitant fraction measurement (12.0±11.6%) was smaller than of the regurgitant blood volume measurement (24.9±17.0%). In the control group the regurgitant blood volume ranged between −25.1 ml and 11.6 ml and the regurgitant fraction between −17.7% and 12.4%.Thus, pulsed Doppler echocardiography is clinically useful in determination of the regurgitant fraction in 84% of unselected adult patients with pure mitral regurgitation. The Doppler method is limited in the diagnosis and quantification of mild regurgitation. However, the method is more accurate in determining the regurgitant fraction than measuring the regurgitant blood volume.

Doppler measurement of cardiac output across prosthetic mitral valves.

SummaryIn 46 patients with a normal functioning mitral valve prosthesis (15 St. Jude, 19 Medtronic Hall, 12 Hancock) cardiac output was measured by pulsed Doppler echocardiography across the valve prosthesis. Simultaneously cardiac output was determined by thermodilution or pulsed Doppler echocardiography in the left ventricular outflow tract (2.8 l/min–9.5 l/min). The prosthetic valve area was calculated using the pressure half-time method. Cardiac output was calculated by multiplying time-velocity integrals with the mitral valve area. Cardiac output measurements across the mitral prosthesis correlated significantly with thermodilution (r=0.96, SEE=0.400 l/min) and pulsed Doppler echocardiography flow measurements in the left ventricular outflow tract (r=0.82, SEE=0.679 l/min). The mean percent error of the Doppler transmitral flow measurement was 10.8%. Doppler transmitral flow underestimated cardiac output values of more than 6.5 l/min in 6 of 7 patients. Cardiac output measurements across Hancock (SEE=0.473 l/min) and St. Jude prostheses (SEE=0.538 l/min) were more accurate than across Medtronic Hall prostheses (SEE=0.847 l/ min).Cardiac output can be calculated by pulsed Doppler echocardiography across normal functioning mitral prostheses. Due to the different flow dynamics the accuracy of cardiac output measurement depends on the prosthetic valve type. Reliable measurements of cardiac output can be performed across Hancock and St. Jude prostheses only. This method is limited in volume flow measurements across Medtronic Hall prostheses.